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The map label for this gene is guaA

Identifier: 15835060

GI number: 15835060

Start: 539629

End: 541167

Strand: Reverse

Name: guaA

Synonym: TC0442

Alternate gene names: 15835060

Gene position: 541167-539629 (Counterclockwise)

Preceding gene: 15835061

Following gene: 15835059

Centisome position: 50.44

GC content: 38.01

Gene sequence:

>1539_bases
TTGAGTAATATTCTCATTCTTGATTTTGGCTCCCAATATACGAATGTTCTAGCAAAAAAAATACGTCTGCTTTCCGTTTT
TTGTGAGGTTCTCCCTTGGAATACACCTTTAGAAAAGATTCTTCAAAAGTCTCCCTCAGGTTTAATTTTTTCAGGAGGAC
CACATTCGGTTTATCAGAATAATAGTCCAGAAGTTGATAAGGAAATCTATAACAGCAACATCCCTATACTTGGAGTGTGC
TATGGCATGCAGCTGATTGCTAGAGATTTTGGAAGTGAAGTTCAGGGGGGGAAGAGCGAATTTGGTTATACACCTATAGT
GTTTTATCCAAGCGAACTTTTTAAAGGTCTTGCTGATCAGGATGCTTTTCATACAGAAATTCGAATGAGTCATTGTGATT
GTGTTGTTGTTCCTCCTAAAGATTTCTTTGTTATAGCGAGTTCTCAGCACTGTCCCATTGCCGCTATAGAATGCCCAAAG
AAAAAACTTTTTGGTCTTCAATTTCATCCTGAAGTTTCAGATTCTCAAGACATAGGGGATAAAATTTTATCAAATTTTGT
GAAGCATATTTGCCAGACTTCAGAAACTTGGAAAATTGAAACAATAGAAAAACAACTTATTCAAGGCATTAGAGAAAAAG
TGGGAGAAACAGAACGTGTCCTTCTCGGCCTATCTGGAGGCGTAGATTCTTCTGTTTTAGCTGTTTTACTTCATAATGCT
CTAGGTGATCGTCTGTCTTGTGTCTTCGTTGATACTGGACTATTACGAAAAAATGAAGTGGAAGAAGTTAAACAACAATT
TTCTTCTCTAGGGTTAGAGATCCTTGTGGTAGATGCTTCTGAAAAATTTTTCCATGACCTATCCGGAATAGAAGATCCTG
AGCAAAAACGTAAAGTCATAGGAGCCGCCTTTATCGAAGTTTTTGATGAAGCCTCTAAAAATCTCGATGTTCAATGGTTA
GCTCAGGGGACTATTTATTCTGATGTAATTGAATCTGCAAAATCTTGTGATGCAACACAAGTAATCAAGTCTCACCATAA
TGTAGGTGGACTTCCAGAAAAGTTGAATTTGAAGCTTTTAGAACCTCTGCGTTTTCTTTTTAAAGATGAAGTCAGAGCTT
TAGGTAAAGTTCTGGGTTTGCCGGACGTCCTAATATCCCGACATCCTTTTCCTGGTCCTGGTTTAGGAGTCCGAGTTCTT
GGAGAAGTTCGTCGGGAATATGTAGAAATAGTAAAAAACGCGGACAGCATTTTTATTGAAGAACTAAAAAAAGCGAATTT
ATACCACAAGGTTAGCCAAGCATTTGCTGTTTTCTTGCCATGTAAATCTGTTGCTGTAAAAGGTGACTGCCGTCATTACG
GTTATACGATAGCTTTACGTGCAGTAGAATCTACTGATTTTATGACAGCATGCTGGCCATCTTTATCTAGAGAATTTCTT
AACCGTTGTTCCTCACGTATCATTAATGAAATCCCTGAAGTTTGCAGGGTAGTTTACGATATTTCCGATAAACCACCGGC
AACTATTGAGTGGGAATAA

Upstream 100 bases:

>100_bases
AATCACTCATTCTGGAAGATCTGAAAGCCACATCCATAACTTGCAATACATTCAGCATGCTCCGAATTATCAAATCTCTA
AATAATAGAGGGTTTCTATT

Downstream 100 bases:

>100_bases
GATCAAAATAAGATATGGTCGATAAGAAGTTTTTTTTTATTATCCAACAGTTGTCACTGTTAACATCTGAGTTGAGCGAT
GACACTCCTTGTACGGATCA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 512; Mature: 511

Protein sequence:

>512_residues
MSNILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEKILQKSPSGLIFSGGPHSVYQNNSPEVDKEIYNSNIPILGVC
YGMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLADQDAFHTEIRMSHCDCVVVPPKDFFVIASSQHCPIAAIECPK
KKLFGLQFHPEVSDSQDIGDKILSNFVKHICQTSETWKIETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVIGAAFIEVFDEASKNLDVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVL
GEVRREYVEIVKNADSIFIEELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFL
NRCSSRIINEIPEVCRVVYDISDKPPATIEWE

Sequences:

>Translated_512_residues
MSNILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEKILQKSPSGLIFSGGPHSVYQNNSPEVDKEIYNSNIPILGVC
YGMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLADQDAFHTEIRMSHCDCVVVPPKDFFVIASSQHCPIAAIECPK
KKLFGLQFHPEVSDSQDIGDKILSNFVKHICQTSETWKIETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNA
LGDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVIGAAFIEVFDEASKNLDVQWL
AQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVL
GEVRREYVEIVKNADSIFIEELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFL
NRCSSRIINEIPEVCRVVYDISDKPPATIEWE
>Mature_511_residues
SNILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEKILQKSPSGLIFSGGPHSVYQNNSPEVDKEIYNSNIPILGVCY
GMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLADQDAFHTEIRMSHCDCVVVPPKDFFVIASSQHCPIAAIECPKK
KLFGLQFHPEVSDSQDIGDKILSNFVKHICQTSETWKIETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNAL
GDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVIGAAFIEVFDEASKNLDVQWLA
QGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLLEPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVLG
EVRREYVEIVKNADSIFIEELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFLN
RCSSRIINEIPEVCRVVYDISDKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=562, Percent_Identity=32.7402135231317, Blast_Score=277, Evalue=1e-74,
Organism=Escherichia coli, GI1788854, Length=521, Percent_Identity=52.3992322456814, Blast_Score=537, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI71992710, Length=572, Percent_Identity=33.9160839160839, Blast_Score=258, Evalue=5e-69,
Organism=Caenorhabditis elegans, GI71992717, Length=572, Percent_Identity=33.9160839160839, Blast_Score=258, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI133901714, Length=572, Percent_Identity=33.9160839160839, Blast_Score=258, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6323873, Length=520, Percent_Identity=47.5, Blast_Score=486, Evalue=1e-138,
Organism=Drosophila melanogaster, GI281365319, Length=547, Percent_Identity=34.3692870201097, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57122; Mature: 56991

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEKILQKSPSGLIFSGGPHSVYQN
CCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCCCCCC
NSPEVDKEIYNSNIPILGVCYGMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLADQ
CCCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHCCCCC
DAFHTEIRMSHCDCVVVPPKDFFVIASSQHCPIAAIECPKKKLFGLQFHPEVSDSQDIGD
CHHHHHHEECCCCEEEECCCCEEEEECCCCCCEEEEECCHHHHCCCEECCCCCCCHHHHH
KILSNFVKHICQTSETWKIETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
LGDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVI
HCCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCHHHHHHHCCCCCHHHHHHHH
GAAFIEVFDEASKNLDVQWLAQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLL
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHCCHHHH
EPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVLGEVRREYVEIVKNADSIFIE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
ELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFL
HHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
NRCSSRIINEIPEVCRVVYDISDKPPATIEWE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SNILILDFGSQYTNVLAKKIRLLSVFCEVLPWNTPLEKILQKSPSGLIFSGGPHSVYQN
CCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCEEECCCCCCCCCC
NSPEVDKEIYNSNIPILGVCYGMQLIARDFGSEVQGGKSEFGYTPIVFYPSELFKGLADQ
CCCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHCCCCC
DAFHTEIRMSHCDCVVVPPKDFFVIASSQHCPIAAIECPKKKLFGLQFHPEVSDSQDIGD
CHHHHHHEECCCCEEEECCCCEEEEECCCCCCEEEEECCHHHHCCCEECCCCCCCHHHHH
KILSNFVKHICQTSETWKIETIEKQLIQGIREKVGETERVLLGLSGGVDSSVLAVLLHNA
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHH
LGDRLSCVFVDTGLLRKNEVEEVKQQFSSLGLEILVVDASEKFFHDLSGIEDPEQKRKVI
HCCCEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEEECCHHHHHHHCCCCCHHHHHHHH
GAAFIEVFDEASKNLDVQWLAQGTIYSDVIESAKSCDATQVIKSHHNVGGLPEKLNLKLL
HHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHCCHHHH
EPLRFLFKDEVRALGKVLGLPDVLISRHPFPGPGLGVRVLGEVRREYVEIVKNADSIFIE
HHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
ELKKANLYHKVSQAFAVFLPCKSVAVKGDCRHYGYTIALRAVESTDFMTACWPSLSREFL
HHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHH
NRCSSRIINEIPEVCRVVYDISDKPPATIEWE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]