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Identifier: 15835061

GI number: 15835061

Start: 541183

End: 542256

Strand: Reverse

Name: Not Available

Synonym: TC0443

Alternate gene names: 15835061

Gene position: 542256-541183 (Counterclockwise)

Preceding gene: 15835063

Following gene: 15835060

Centisome position: 50.54

GC content: 41.71

Gene sequence:

>1074_bases
ATGCGCGAAGCTCTGACTTTTGATGATGTTTTATTAGTTCCTCAGTATTCTGAAGTTCTTCCTCAAGATGCTTGTTTAAC
TTCTTCTGTTTCAGAATCTTTATCTTTAACTATCCCTATCTTATCCGCAGCAATGGATTCCGTCACAGAGTTGTCTATGG
CTACAGCCATGAGTGTGGCAGGAGGACTTGGGATTGTTCACAAAAATATGGATGTGAATGCACAAGTTGCCATCGTAAAA
CAGATAAAATCGCAAAGTACCTCTTCAGTAATTGGCGGTGCCGTAGGTATCGGTCAACAAGGTTTAGAAAGAGCAGAAGC
TTTAGTTGAGGCAGGTATAGATACTTTAGTAGTCGATACTGCTCATGGGCATTCTAAATTGGTGCTTGATACAGCATTTA
CCATTAAAAAGAATTATCCTGTAACTCTCATTGTGGGGAATATTGTTTCAAAGGCAGCTGCTCTTTGTTTGGCTGAAATT
GGTGTGGACGCTGTTAAAGTGGGGATTGGTCCCGGATCGATATGTACAACGCGGATTGTCTCGGGTGTAGGATTGCCTCA
ATTGACAGCAATTATGGATGTTGCTGAAGCGTTGCATGATTCTTCTGTACGTATCATTGCCGATGGGGGGATGCGCTATT
CTGGAGACATTGTTAAAGCTCTAGCTGCTGGAGCGCATTGTGTTATGCTCGGTAGCATGTTAGCAGGAACTGATGAGGCT
CCTGGAGAAATCGTTCAGATTAATGAACATTCTTACAAGATGTATCGAGGTATGGGTTCTCTCGGTGCTATGAAGAAAGG
TAGTGCTGAACGCTATTTTCAAAAAAATAATGCTAAAAAGTTTGTTCCAGAGGGTGTTGAAGGGCTTGTGCCTTATAAAG
GCTCTCTTCACGACGTTCTCTATCAAATTTTAGGAGGGATTCGATCAGGAATGGGCTATTTGGGAGCTCATAATTTAGAA
GAATTGCGCCAGAATGCTGTATTTTCCCGAATCACTCATTCTGGAAGATCTGAAAGCCACATCCATAACTTGCAATACAT
TCAGCATGCTCCGAATTATCAAATCTCTAAATAA

Upstream 100 bases:

>100_bases
TTAACTCTATTCGAGTGCGATTTTTCTTTTATTTATTACTGATGAGAAAAAGTTTCTCAATCAGCCTCGGTCTTAGTCAT
TTTTCCTCATTGAGAAGTAT

Downstream 100 bases:

>100_bases
TAGAGGGTTTCTATTTTGAGTAATATTCTCATTCTTGATTTTGGCTCCCAATATACGAATGTTCTAGCAAAAAAAATACG
TCTGCTTTCCGTTTTTTGTG

Product: inosine-5`-monophosphate dehydrogenase, putative

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MREALTFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVAGGLGIVHKNMDVNAQVAIVK
QIKSQSTSSVIGGAVGIGQQGLERAEALVEAGIDTLVVDTAHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAAALCLAEI
GVDAVKVGIGPGSICTTRIVSGVGLPQLTAIMDVAEALHDSSVRIIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTDEA
PGEIVQINEHSYKMYRGMGSLGAMKKGSAERYFQKNNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYLGAHNLE
ELRQNAVFSRITHSGRSESHIHNLQYIQHAPNYQISK

Sequences:

>Translated_357_residues
MREALTFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVAGGLGIVHKNMDVNAQVAIVK
QIKSQSTSSVIGGAVGIGQQGLERAEALVEAGIDTLVVDTAHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAAALCLAEI
GVDAVKVGIGPGSICTTRIVSGVGLPQLTAIMDVAEALHDSSVRIIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTDEA
PGEIVQINEHSYKMYRGMGSLGAMKKGSAERYFQKNNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYLGAHNLE
ELRQNAVFSRITHSGRSESHIHNLQYIQHAPNYQISK
>Mature_357_residues
MREALTFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVAGGLGIVHKNMDVNAQVAIVK
QIKSQSTSSVIGGAVGIGQQGLERAEALVEAGIDTLVVDTAHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAAALCLAEI
GVDAVKVGIGPGSICTTRIVSGVGLPQLTAIMDVAEALHDSSVRIIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTDEA
PGEIVQINEHSYKMYRGMGSLGAMKKGSAERYFQKNNAKKFVPEGVEGLVPYKGSLHDVLYQILGGIRSGMGYLGAHNLE
ELRQNAVFSRITHSGRSESHIHNLQYIQHAPNYQISK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the IMPDH/GMPR family [H]

Homologues:

Organism=Homo sapiens, GI50541954, Length=337, Percent_Identity=36.2017804154303, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI50541952, Length=337, Percent_Identity=36.2017804154303, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI50541948, Length=337, Percent_Identity=36.2017804154303, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI50541956, Length=337, Percent_Identity=36.2017804154303, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI156104880, Length=339, Percent_Identity=34.8082595870207, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI217035150, Length=270, Percent_Identity=40, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI217035148, Length=270, Percent_Identity=40, Blast_Score=168, Evalue=8e-42,
Organism=Homo sapiens, GI217035146, Length=270, Percent_Identity=40, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI156616279, Length=270, Percent_Identity=40, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI34328930, Length=270, Percent_Identity=40, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI34328928, Length=270, Percent_Identity=40, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI66933016, Length=263, Percent_Identity=40.3041825095057, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI217035152, Length=270, Percent_Identity=40, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1788855, Length=255, Percent_Identity=55.6862745098039, Blast_Score=266, Evalue=1e-72,
Organism=Escherichia coli, GI1786293, Length=350, Percent_Identity=33.1428571428571, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17560440, Length=339, Percent_Identity=33.0383480825959, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI71994385, Length=268, Percent_Identity=35.8208955223881, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI71994389, Length=188, Percent_Identity=41.4893617021277, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323585, Length=290, Percent_Identity=34.8275862068965, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323464, Length=290, Percent_Identity=34.8275862068965, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322012, Length=275, Percent_Identity=36.3636363636364, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319352, Length=132, Percent_Identity=37.1212121212121, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319353, Length=129, Percent_Identity=36.4341085271318, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28571163, Length=360, Percent_Identity=33.8888888888889, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641071, Length=360, Percent_Identity=33.8888888888889, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24641073, Length=360, Percent_Identity=33.8888888888889, Blast_Score=169, Evalue=2e-42,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 37643; Mature: 37643

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREALTFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVA
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
GGLGIVHKNMDVNAQVAIVKQIKSQSTSSVIGGAVGIGQQGLERAEALVEAGIDTLVVDT
CCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEC
AHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAAALCLAEIGVDAVKVGIGPGSICTTRIV
CCCCCEEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
SGVGLPQLTAIMDVAEALHDSSVRIIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTDEA
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHCCHHHHHHHHHHCCCCCC
PGEIVQINEHSYKMYRGMGSLGAMKKGSAERYFQKNNAKKFVPEGVEGLVPYKGSLHDVL
CCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
YQILGGIRSGMGYLGAHNLEELRQNAVFSRITHSGRSESHIHNLQYIQHAPNYQISK
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MREALTFDDVLLVPQYSEVLPQDACLTSSVSESLSLTIPILSAAMDSVTELSMATAMSVA
CCCCCCCCCEEECCCHHHHCCCHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHH
GGLGIVHKNMDVNAQVAIVKQIKSQSTSSVIGGAVGIGQQGLERAEALVEAGIDTLVVDT
CCCEEEECCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEC
AHGHSKLVLDTAFTIKKNYPVTLIVGNIVSKAAALCLAEIGVDAVKVGIGPGSICTTRIV
CCCCCEEEEEEEEEEECCCCEEEEEHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHH
SGVGLPQLTAIMDVAEALHDSSVRIIADGGMRYSGDIVKALAAGAHCVMLGSMLAGTDEA
HCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEECHHHHHHHHCCHHHHHHHHHHCCCCCC
PGEIVQINEHSYKMYRGMGSLGAMKKGSAERYFQKNNAKKFVPEGVEGLVPYKGSLHDVL
CCCEEEECCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
YQILGGIRSGMGYLGAHNLEELRQNAVFSRITHSGRSESHIHNLQYIQHAPNYQISK
HHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961392; 9403685; 10758003 [H]