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Identifier: 15834689

GI number: 15834689

Start: 73311

End: 74591

Strand: Direct

Name: Not Available

Synonym: TC0064

Alternate gene names: 15834689

Gene position: 73311-74591 (Clockwise)

Preceding gene: 15834688

Following gene: 15834690

Centisome position: 6.83

GC content: 43.64

Gene sequence:

>1281_bases
ATGTGGTGGCTGCTGGTTTGTGTGGTTATAGGCGGATTCTACACTGCTTGGAACATAGGCGCTAATGATGTAGCGAATGC
TGTGGGGCCAAGTGTAGGGGCTGGCGTGTTGACTTTGCGACAGGCTGTTCTCATTGCTGCGGTTTTTGAATTCCTTGGAG
CTGTGGTATTAGGGGATCGAGTTATCGGTACCATTGAAAGTGGTTTAGTGGCGCCGGCCGATCATGTTCTGTCTTCCCAA
GATTATGTCTTTGGAATGACAGCAGCTCTTTTTGCTACTGGTGTTTGGTTACAGATAGCATCTTTTTTTGGGTGGCCAGT
ATCAACAACCCATGCTATTGTGGGAGGCGTTTTAGGCTTTGGAATCATCCTTAAAGAGGATGCTGTTATCTATTGGGATT
CCTGTGCTCGAATATTTGTCAGCTGGTTAGCCTCTCCTATTATTGGGGGATATTTCGCTTTTCTTATTTTCTCTTTTATT
CGAAAAGCCATTCTTTATAAAAGAGATCCAGTTTCTGCCATGGTGCGTATAGCTCCGTTTCTATCTGCTATTATTATTTT
TGCTTTAGGTTTGATCCTTATCCTTAGTGGAGCAGTGGCTCGTGTAGTGGCTTTTCCTGTAGCTTTCCGCGTTGTTTGTG
GATTAGTTGTTTTCGCTTTTGCCTTTACGATTTGGGGAGTGCACTTTTTTAAACTGGCCGTTCTCCCTCAAAAAGTGGGG
CCAGGAACATTGTTAGATCGACTGTTATCCAAAAGTACAGATTATGGACGACAGTACCTTGTTGTTGAGCGTATTTTTGC
TTACTTACAAATAGTCATTGCGTGCTTTATGTCTTTTGCCCACGGGTCTAATGATGTTGCCAATGCTATAGCTCCTGTTG
CTGGTATTTATCGGGCTCTATATCCGCAAAGTTACTCTCCGAAAGTTCTCTTTATATTCATGTCTCTAGGGGGCTTAGGT
TTAGTCTTTGGATTGGCAACATGGGGTTGGCGTGTAATTGATACTATTGGGAAAAAAATCACAGAGCTTACGCCATCGAG
AGGGTTCTCTGTAGGAATGAGCTCGGCTATCACTATTGCAGCAGCATCTGCTTTTGGATTCCCTATATCAACTACACATG
TTGTTGTGGGTGCCGTATTGGGGGTAGGGTTAGCAAGAGGGCTGCAAGCTATCAATCTACGGATTATTAAAGACATTGTA
CTCTCGTGGTTTGTTACAGTGCCCGCAGGAGCAGCTCTTTCCATCATGTTTTTTTTGTTATTACGCGCAGTATTTTGTTA
A

Upstream 100 bases:

>100_bases
TTGTTCTTTGGACACAAATTATTAAGAGGCTATCGGGAATATCTAATAATTCCGAGAAACTAGCTTATCGAGTGGGTATG
ACTCTAGAAGAGAAATAGGC

Downstream 100 bases:

>100_bases
GCGCAGATCCTTATATTCAGGATCAAGAAGTTTTTGTCTGAACAATTCTTCTTATTTAGCTTTGATAAAGGCTTGAGTTT
TCTGTTGTTTAGGCGCTATA

Product: phosphate permease family protein

Products: Proton [Cytoplasm]; phosphate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MWWLLVCVVIGGFYTAWNIGANDVANAVGPSVGAGVLTLRQAVLIAAVFEFLGAVVLGDRVIGTIESGLVAPADHVLSSQ
DYVFGMTAALFATGVWLQIASFFGWPVSTTHAIVGGVLGFGIILKEDAVIYWDSCARIFVSWLASPIIGGYFAFLIFSFI
RKAILYKRDPVSAMVRIAPFLSAIIIFALGLILILSGAVARVVAFPVAFRVVCGLVVFAFAFTIWGVHFFKLAVLPQKVG
PGTLLDRLLSKSTDYGRQYLVVERIFAYLQIVIACFMSFAHGSNDVANAIAPVAGIYRALYPQSYSPKVLFIFMSLGGLG
LVFGLATWGWRVIDTIGKKITELTPSRGFSVGMSSAITIAAASAFGFPISTTHVVVGAVLGVGLARGLQAINLRIIKDIV
LSWFVTVPAGAALSIMFFLLLRAVFC

Sequences:

>Translated_426_residues
MWWLLVCVVIGGFYTAWNIGANDVANAVGPSVGAGVLTLRQAVLIAAVFEFLGAVVLGDRVIGTIESGLVAPADHVLSSQ
DYVFGMTAALFATGVWLQIASFFGWPVSTTHAIVGGVLGFGIILKEDAVIYWDSCARIFVSWLASPIIGGYFAFLIFSFI
RKAILYKRDPVSAMVRIAPFLSAIIIFALGLILILSGAVARVVAFPVAFRVVCGLVVFAFAFTIWGVHFFKLAVLPQKVG
PGTLLDRLLSKSTDYGRQYLVVERIFAYLQIVIACFMSFAHGSNDVANAIAPVAGIYRALYPQSYSPKVLFIFMSLGGLG
LVFGLATWGWRVIDTIGKKITELTPSRGFSVGMSSAITIAAASAFGFPISTTHVVVGAVLGVGLARGLQAINLRIIKDIV
LSWFVTVPAGAALSIMFFLLLRAVFC
>Mature_426_residues
MWWLLVCVVIGGFYTAWNIGANDVANAVGPSVGAGVLTLRQAVLIAAVFEFLGAVVLGDRVIGTIESGLVAPADHVLSSQ
DYVFGMTAALFATGVWLQIASFFGWPVSTTHAIVGGVLGFGIILKEDAVIYWDSCARIFVSWLASPIIGGYFAFLIFSFI
RKAILYKRDPVSAMVRIAPFLSAIIIFALGLILILSGAVARVVAFPVAFRVVCGLVVFAFAFTIWGVHFFKLAVLPQKVG
PGTLLDRLLSKSTDYGRQYLVVERIFAYLQIVIACFMSFAHGSNDVANAIAPVAGIYRALYPQSYSPKVLFIFMSLGGLG
LVFGLATWGWRVIDTIGKKITELTPSRGFSVGMSSAITIAAASAFGFPISTTHVVVGAVLGVGLARGLQAINLRIIKDIV
LSWFVTVPAGAALSIMFFLLLRAVFC

Specific function: Potential transporter for phosphate

COG id: COG0306

COG function: function code P; Phosphate/sulphate permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family

Homologues:

Organism=Homo sapiens, GI31543630, Length=178, Percent_Identity=43.2584269662921, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI5803173, Length=165, Percent_Identity=43.030303030303, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71981576, Length=449, Percent_Identity=31.4031180400891, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17539280, Length=499, Percent_Identity=28.8577154308617, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17536725, Length=480, Percent_Identity=26.6666666666667, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17557328, Length=489, Percent_Identity=25.7668711656442, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI32566716, Length=170, Percent_Identity=42.3529411764706, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25146401, Length=177, Percent_Identity=35.5932203389831, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6319773, Length=150, Percent_Identity=39.3333333333333, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21356511, Length=197, Percent_Identity=35.5329949238579, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y064_CHLMU (Q9PLN5)

Other databases:

- EMBL:   AE002160
- RefSeq:   NP_296448.1
- GeneID:   1245593
- GenomeReviews:   AE002160_GR
- KEGG:   cmu:TC0064
- TIGR:   TC_0064
- HOGENOM:   HBG681698
- OMA:   KLNPMRA
- PhylomeDB:   Q9PLN5
- ProtClustDB:   CLSK871542
- BioCyc:   CMUR243161:TC_0064-MONOMER
- InterPro:   IPR001204
- PANTHER:   PTHR11101

Pfam domain/function: PF01384 PHO4

EC number: NA

Molecular weight: Translated: 45571; Mature: 45571

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x91f9ed4)-; HASH(0xafebb74)-; HASH(0x4039b814)-; HASH(0x403bc5a4)-; HASH(0x403a3b9c)-; HASH(0xb822a78)-; HASH(0xaf2e8b0)-; HASH(0x403b02d4)-; HASH(0xba986ec)-; HASH(0xc35999c)-; HASH(0xb2a07c0)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWWLLVCVVIGGFYTAWNIGANDVANAVGPSVGAGVLTLRQAVLIAAVFEFLGAVVLGDR
CHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
VIGTIESGLVAPADHVLSSQDYVFGMTAALFATGVWLQIASFFGWPVSTTHAIVGGVLGF
HHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GIILKEDAVIYWDSCARIFVSWLASPIIGGYFAFLIFSFIRKAILYKRDPVSAMVRIAPF
HHHEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LSAIIIFALGLILILSGAVARVVAFPVAFRVVCGLVVFAFAFTIWGVHFFKLAVLPQKVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PGTLLDRLLSKSTDYGRQYLVVERIFAYLQIVIACFMSFAHGSNDVANAIAPVAGIYRAL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
YPQSYSPKVLFIFMSLGGLGLVFGLATWGWRVIDTIGKKITELTPSRGFSVGMSSAITIA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
AASAFGFPISTTHVVVGAVLGVGLARGLQAINLRIIKDIVLSWFVTVPAGAALSIMFFLL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LRAVFC
HHHHHH
>Mature Secondary Structure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HHHHHH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; phosphate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + phosphate [Periplasm] = Proton [Cytoplasm] + phosphate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10684935