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The map label for this gene is pth

Identifier: 15836483

GI number: 15836483

Start: 1085837

End: 1086379

Strand: Direct

Name: pth

Synonym: CPj0950

Alternate gene names: 15836483

Gene position: 1085837-1086379 (Clockwise)

Preceding gene: 15836482

Following gene: 15836484

Centisome position: 88.53

GC content: 41.8

Gene sequence:

>543_bases
ATGGCTAAGCTCATTGTAGCGATAGGGAACCCTAGGCATGGGTATGCAAATACTAGACATAACGCAGGGTTCCTATTGGC
TGATAGGTTAGTGGAGGAGCTCCAAGGCCCCCCATTTAAACCGTTATCAAAATGCCATGCTTTAATGACTCTCGTAGAGT
CTTCTTCAGGGCCTTTGGTTTTTATTAAACCAACAACTTTTGTCAATTTAAGCGGTAAAGCCGTGGTTTTGGCTAAAAAA
TATTTTAATGTTGCTCTGAGTCACATTCTAGTTCTCGCTGATGATGTGAACCGTTCGTTTGGTAAACTTCGCCTTTGTTT
TAACGGAGGAAGTGGGGGACACAATGGTCTTAAGAGCATTACTGCCAGCTTGGGTTCCAATGAATATTGGCAATTACGGT
TCGGTGTAGGAAGACCCCTCGAAGAGGGTGTTGAGCTATCTAATTTCGTTTTAGGAAAGTTTTCTGAAGAAGAAAATCTT
CAGTTGGGATCCATATTTGTTGAGGCATCTACTCTATTTACCGAGTGGTGTTCGAAATTTTAA

Upstream 100 bases:

>100_bases
CTTTCTCAAACGAGAAAACTATCCGATATAAAGATCCCTGCTGGAATAGAAACAATTACACCTTTGAAAGAAGTCGCTAT
AACCGTCTCTAGAAGATAAT

Downstream 100 bases:

>100_bases
ATGGCTTGAGAAGTTTCTGAAATAATTTTAGTGGACTGAGATATCTTAAGGATAATAAACTACTCTATCTGTCTGTGTTT
AGGAGTTTTTAATGGGAAAA

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MAKLIVAIGNPRHGYANTRHNAGFLLADRLVEELQGPPFKPLSKCHALMTLVESSSGPLVFIKPTTFVNLSGKAVVLAKK
YFNVALSHILVLADDVNRSFGKLRLCFNGGSGGHNGLKSITASLGSNEYWQLRFGVGRPLEEGVELSNFVLGKFSEEENL
QLGSIFVEASTLFTEWCSKF

Sequences:

>Translated_180_residues
MAKLIVAIGNPRHGYANTRHNAGFLLADRLVEELQGPPFKPLSKCHALMTLVESSSGPLVFIKPTTFVNLSGKAVVLAKK
YFNVALSHILVLADDVNRSFGKLRLCFNGGSGGHNGLKSITASLGSNEYWQLRFGVGRPLEEGVELSNFVLGKFSEEENL
QLGSIFVEASTLFTEWCSKF
>Mature_179_residues
AKLIVAIGNPRHGYANTRHNAGFLLADRLVEELQGPPFKPLSKCHALMTLVESSSGPLVFIKPTTFVNLSGKAVVLAKKY
FNVALSHILVLADDVNRSFGKLRLCFNGGSGGHNGLKSITASLGSNEYWQLRFGVGRPLEEGVELSNFVLGKFSEEENLQ
LGSIFVEASTLFTEWCSKF

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=174, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=7e-16,
Organism=Escherichia coli, GI1787455, Length=175, Percent_Identity=37.1428571428571, Blast_Score=83, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_CHLPN (Q9Z6V6)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86609
- PIR:   E72014
- RefSeq:   NP_225145.1
- RefSeq:   NP_301007.1
- RefSeq:   NP_445446.1
- RefSeq:   NP_877259.1
- ProteinModelPortal:   Q9Z6V6
- SMR:   Q9Z6V6
- GeneID:   1467666
- GeneID:   895643
- GeneID:   919713
- GeneID:   963366
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0909
- KEGG:   cpn:CPn0950
- KEGG:   cpt:CpB0987
- TIGR:   CP_0909
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   Q9Z6V6
- ProtClustDB:   PRK05426
- BioCyc:   CPNE115711:CP_0909-MONOMER
- BioCyc:   CPNE115713:CPN0950-MONOMER
- BioCyc:   CPNE138677:CPJ0950-MONOMER
- BioCyc:   CPNE182082:CPB0987-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 19645; Mature: 19514

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKLIVAIGNPRHGYANTRHNAGFLLADRLVEELQGPPFKPLSKCHALMTLVESSSGPLV
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEE
FIKPTTFVNLSGKAVVLAKKYFNVALSHILVLADDVNRSFGKLRLCFNGGSGGHNGLKSI
EECCCEEEECCCCEEEEHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCHHHHHH
TASLGSNEYWQLRFGVGRPLEEGVELSNFVLGKFSEEENLQLGSIFVEASTLFTEWCSKF
HHHCCCCCEEEEEECCCCCHHHCCCHHHHEEECCCCCCCCEEEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
AKLIVAIGNPRHGYANTRHNAGFLLADRLVEELQGPPFKPLSKCHALMTLVESSSGPLV
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEE
FIKPTTFVNLSGKAVVLAKKYFNVALSHILVLADDVNRSFGKLRLCFNGGSGGHNGLKSI
EECCCEEEECCCCEEEEHHHHHHHHHHHHHEEECCCCCCCCEEEEEEECCCCCCHHHHHH
TASLGSNEYWQLRFGVGRPLEEGVELSNFVLGKFSEEENLQLGSIFVEASTLFTEWCSKF
HHHCCCCCEEEEEECCCCCHHHCCCHHHHEEECCCCCCCCEEEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362