| Definition | Chlamydophila pneumoniae J138, complete genome. |
|---|---|
| Accession | NC_002491 |
| Length | 1,226,565 |
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The map label for this gene is murC_ddlA
Identifier: 15836438
GI number: 15836438
Start: 1036730
End: 1039159
Strand: Direct
Name: murC_ddlA
Synonym: CPj0905
Alternate gene names: 15836438
Gene position: 1036730-1039159 (Clockwise)
Preceding gene: 15836437
Following gene: 15836442
Centisome position: 84.52
GC content: 40.95
Gene sequence:
>2430_bases ATGAAGGGAACTCCTCAGTATCATTTTATCGGTATCGGTGGTATAGGAATGAGCGCTTTAGCTCATATTTTGCTTGATCG TGGCTATGAGGTCTCTGGAAGCGACTTATATGAAAGCTATACGATCGAAAGCCTGAAAGCTAAAGGTGCGAGGTGTTTCT CAGGCCATGATTCCTCCCATGTTCCTCATGATGCCGTCGTTGTTTATAGCTCAAGTATAGCCCCTGATAATGTAGAGTAT CTTACCGCTATTCAAAGATCATCACGTCTTCTTCATAGAGCAGAGCTCTTGAGTCAGCTTATGGAGGGTTATGAAAGCAT TCTGGTTTCAGGAAGCCATGGGAAGACAGGGACCTCATCTCTAATTCGAGCGATTTTCCAGGAAGCTCAGAAAGATCCCT CCTATGCTATTGGAGGACTCGCTGCAAACTGCCTGAATGGGTATTCTGGATCATCGAAAATCTTCGTTGCCGAAGCCGAT GAAAGTGATGGGTCTTTAAAGCACTACACTCCCCGTGCAGTAGTCATTACAAATATAGATAATGAACATTTGAATAATTA CGCTGGGAATCTTGATAACCTGGTTCAGGTAATCCAGGACTTCTCTAGAAAAGTAACAGATCTCAATAAGGTATTCTATA ACGGGGATTGTCCTATTTTGAAAGGAAATGTCCAAGGGATTTCTTATGGATATTCACCAGAATGTCAATTGCATATCGTT TCCTATAATCAAAAGGCATGGCAATCTCACTTTTCCTTTACCTTTTTAGGCCAGGAGTATCAAGACATTGAGCTCAATCT CCCTGGACAACATAACGCTGCAAATGCAGCAGCAGCCTGTGGAGTTGCTCTTACCTTTGGCATAGACATAAACATCATTC GAAAAGCTCTCAAAAAATTCTCGGGAGTTCATCGACGTCTAGAAAGAAAAAATATATCCGAAAGCTTTCTTTTCTTAGAA GATTATGCTCATCATCCTGTAGAGGTTGCACATACCCTGCGCTCTGTGCGTGATGCTGTGGGTTTGCGAAGAGTCATCGC AATTTTTCAACCACATCGATTCTCTCGTTTAGAAGAGTGCTTACAAACCTTCCCCAAAGCTTTCCAAGAAGCTGATGAAG TCATACTTACAGATGTCTATAGTGCCGGAGAAAGTCCTAGAGAGTCTATCATTCTTTCCGACCTTGCGGAACAGATTCGT AAGTCTTCTTATGTCCATTGTTGTTATGTTCCCCATGGAGACATCGTAGATTATCTACGAAACTACATTCGCATTCATGA TGTCTGTGTTTCTCTAGGAGCTGGAAATATCTATACTATTGGAGAGGCTTTAAAAGACTTTAACCCTAAAAAATTATCCA TAGGACTCGTCTGTGGAGGGAAATCTTGCGAACACGATATTTCTCTACTTTCTGCTCAACATGTCTCTAAATATATTTCT CCTGAATTCTATGATGTGAGTTACTTCATCATAAATCGTCAGGGCTTATGGAGAACAGGAAAGGATTTTCCTCATCTTAT TGAAGAGACTCAAGGGGATTCGCCACTTTCTTCTGAAATCGCTTCAGCTTTAGCAAAAGTCGACTGTTTGTTTCCCGTGC TCCATGGCCCATTTGGAGAGGATGGTACGATCCAGGGATTTTTTGAAATCTTAGGAAAACCTTATGCCGGACCCTCACTA TCTTTAGCAGCAACTGCAATGGATAAGCTGTTAACAAAACGAATTGCATCAGCAGTGGGTGTTCCTGTAGTCCCTTACCA ACCTTTAAATCTCTGTTTCTGGAAACGCAATCCAGAACTATGTATTCAGAATCTTATAGAGACATTTTCTTTCCCTATGA TTGTAAAAACTGCACATTTGGGATCTAGTATTGGGATATTTTTAGTCCGTGATAAAGAGGAATTACAAGAAAAGATCTCA GAAGCATTTCTATATGACACGGATGTGTTTGTGGAGGAAAGTCGCTTAGGGTCTCGTGAAATCGAAGTGTCCTGTATCGG CCATTCTTCTAGCTGGTATTGTATGGCAGGGCCTAATGAACGCTGTGGTGCTAGTGGGTTTATTGATTATCAAGAGAAAT ATGGATTTGATGGCATAGATTGCGCAAAGATCTCTTTTGATTTACAGCTCTCACAAGAATCTTTAGATTGTGTTAGAGAA CTTGCAGAGCGTGTCTACCGAGCAATGCAAGGAAAAGGTTCAGCTCGAATAGATTTTTTCTTGGATGAAGAGGGGAATTA TTGGTTGTCAGAGGTCAATCCTATTCCAGGAATGACAGCAGCTAGCCCATTTTTACAAGCTTTTGTTCACGCAGGATGGA CGCAAGAACAAATTGTAGATCACTTTATTATAGATGCTCTACATAAGTTTGATAAGCAGCAGACTATCGAACAGGCATTC ACTAAAGAACAAGATTTAGTTAAAAGATAA
Upstream 100 bases:
>100_bases TAACAGAGAAAAACAACGCAATTCCCTAGCGGCGTATAGTCAGCAAAGGTCAACAAAAACATTCCATGCATTCATTTGTG AATGCTTATAGGTTCATTAT
Downstream 100 bases:
>100_bases TAAAAAAACTAGAGATCTTTTTATTAAAATCTCTAGTTTTTACATGTAAACAAAAGCAGACGAATAACTACGATTAATGG TGGTTACTACATTCGCAAGA
Product: bifunctional D-alanyl-alanine synthetase A/UDP-N-acetylmuramate--L-alanine ligase
Products: NA
Alternate protein names: UDP-N-acetylmuramate--L-alanine ligase; UDP-N-acetylmuramoyl-L-alanine synthetase; D-alanine--D-alanine ligase; D-Ala-D-Ala ligase; D-alanylalanine synthetase
Number of amino acids: Translated: 809; Mature: 809
Protein sequence:
>809_residues MKGTPQYHFIGIGGIGMSALAHILLDRGYEVSGSDLYESYTIESLKAKGARCFSGHDSSHVPHDAVVVYSSSIAPDNVEY LTAIQRSSRLLHRAELLSQLMEGYESILVSGSHGKTGTSSLIRAIFQEAQKDPSYAIGGLAANCLNGYSGSSKIFVAEAD ESDGSLKHYTPRAVVITNIDNEHLNNYAGNLDNLVQVIQDFSRKVTDLNKVFYNGDCPILKGNVQGISYGYSPECQLHIV SYNQKAWQSHFSFTFLGQEYQDIELNLPGQHNAANAAAACGVALTFGIDINIIRKALKKFSGVHRRLERKNISESFLFLE DYAHHPVEVAHTLRSVRDAVGLRRVIAIFQPHRFSRLEECLQTFPKAFQEADEVILTDVYSAGESPRESIILSDLAEQIR KSSYVHCCYVPHGDIVDYLRNYIRIHDVCVSLGAGNIYTIGEALKDFNPKKLSIGLVCGGKSCEHDISLLSAQHVSKYIS PEFYDVSYFIINRQGLWRTGKDFPHLIEETQGDSPLSSEIASALAKVDCLFPVLHGPFGEDGTIQGFFEILGKPYAGPSL SLAATAMDKLLTKRIASAVGVPVVPYQPLNLCFWKRNPELCIQNLIETFSFPMIVKTAHLGSSIGIFLVRDKEELQEKIS EAFLYDTDVFVEESRLGSREIEVSCIGHSSSWYCMAGPNERCGASGFIDYQEKYGFDGIDCAKISFDLQLSQESLDCVRE LAERVYRAMQGKGSARIDFFLDEEGNYWLSEVNPIPGMTAASPFLQAFVHAGWTQEQIVDHFIIDALHKFDKQQTIEQAF TKEQDLVKR
Sequences:
>Translated_809_residues MKGTPQYHFIGIGGIGMSALAHILLDRGYEVSGSDLYESYTIESLKAKGARCFSGHDSSHVPHDAVVVYSSSIAPDNVEY LTAIQRSSRLLHRAELLSQLMEGYESILVSGSHGKTGTSSLIRAIFQEAQKDPSYAIGGLAANCLNGYSGSSKIFVAEAD ESDGSLKHYTPRAVVITNIDNEHLNNYAGNLDNLVQVIQDFSRKVTDLNKVFYNGDCPILKGNVQGISYGYSPECQLHIV SYNQKAWQSHFSFTFLGQEYQDIELNLPGQHNAANAAAACGVALTFGIDINIIRKALKKFSGVHRRLERKNISESFLFLE DYAHHPVEVAHTLRSVRDAVGLRRVIAIFQPHRFSRLEECLQTFPKAFQEADEVILTDVYSAGESPRESIILSDLAEQIR KSSYVHCCYVPHGDIVDYLRNYIRIHDVCVSLGAGNIYTIGEALKDFNPKKLSIGLVCGGKSCEHDISLLSAQHVSKYIS PEFYDVSYFIINRQGLWRTGKDFPHLIEETQGDSPLSSEIASALAKVDCLFPVLHGPFGEDGTIQGFFEILGKPYAGPSL SLAATAMDKLLTKRIASAVGVPVVPYQPLNLCFWKRNPELCIQNLIETFSFPMIVKTAHLGSSIGIFLVRDKEELQEKIS EAFLYDTDVFVEESRLGSREIEVSCIGHSSSWYCMAGPNERCGASGFIDYQEKYGFDGIDCAKISFDLQLSQESLDCVRE LAERVYRAMQGKGSARIDFFLDEEGNYWLSEVNPIPGMTAASPFLQAFVHAGWTQEQIVDHFIIDALHKFDKQQTIEQAF TKEQDLVKR >Mature_809_residues MKGTPQYHFIGIGGIGMSALAHILLDRGYEVSGSDLYESYTIESLKAKGARCFSGHDSSHVPHDAVVVYSSSIAPDNVEY LTAIQRSSRLLHRAELLSQLMEGYESILVSGSHGKTGTSSLIRAIFQEAQKDPSYAIGGLAANCLNGYSGSSKIFVAEAD ESDGSLKHYTPRAVVITNIDNEHLNNYAGNLDNLVQVIQDFSRKVTDLNKVFYNGDCPILKGNVQGISYGYSPECQLHIV SYNQKAWQSHFSFTFLGQEYQDIELNLPGQHNAANAAAACGVALTFGIDINIIRKALKKFSGVHRRLERKNISESFLFLE DYAHHPVEVAHTLRSVRDAVGLRRVIAIFQPHRFSRLEECLQTFPKAFQEADEVILTDVYSAGESPRESIILSDLAEQIR KSSYVHCCYVPHGDIVDYLRNYIRIHDVCVSLGAGNIYTIGEALKDFNPKKLSIGLVCGGKSCEHDISLLSAQHVSKYIS PEFYDVSYFIINRQGLWRTGKDFPHLIEETQGDSPLSSEIASALAKVDCLFPVLHGPFGEDGTIQGFFEILGKPYAGPSL SLAATAMDKLLTKRIASAVGVPVVPYQPLNLCFWKRNPELCIQNLIETFSFPMIVKTAHLGSSIGIFLVRDKEELQEKIS EAFLYDTDVFVEESRLGSREIEVSCIGHSSSWYCMAGPNERCGASGFIDYQEKYGFDGIDCAKISFDLQLSQESLDCVRE LAERVYRAMQGKGSARIDFFLDEEGNYWLSEVNPIPGMTAASPFLQAFVHAGWTQEQIVDHFIIDALHKFDKQQTIEQAF TKEQDLVKR
Specific function: Cell wall formation
COG id: COG0773
COG function: function code M; UDP-N-acetylmuramate-alanine ligase
Gene ontology:
Cell location: Cytoplasm (Probable)
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 ATP-grasp domain
Homologues:
Organism=Escherichia coli, GI1786279, Length=466, Percent_Identity=33.2618025751073, Blast_Score=219, Evalue=4e-58, Organism=Escherichia coli, GI1786579, Length=363, Percent_Identity=28.6501377410468, Blast_Score=155, Evalue=8e-39, Organism=Escherichia coli, GI1790680, Length=395, Percent_Identity=26.0759493670886, Blast_Score=123, Evalue=4e-29, Organism=Escherichia coli, GI1786280, Length=255, Percent_Identity=34.1176470588235, Blast_Score=119, Evalue=6e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): MUDD_CHLPN (Q9Z701)
Other databases:
- EMBL: AE001363 - EMBL: AE002161 - EMBL: BA000008 - EMBL: AE009440 - PIR: D72022 - PIR: G86603 - RefSeq: NP_225100.1 - RefSeq: NP_300962.1 - RefSeq: NP_445498.1 - RefSeq: NP_877209.1 - ProteinModelPortal: Q9Z701 - PHCI-2DPAGE: Q9Z701 - GeneID: 1467616 - GeneID: 895305 - GeneID: 919670 - GeneID: 963426 - GenomeReviews: AE001363_GR - GenomeReviews: AE002161_GR - GenomeReviews: AE009440_GR - GenomeReviews: BA000008_GR - KEGG: cpa:CP0961 - KEGG: cpn:CPn0905 - KEGG: cpt:CpB0937 - TIGR: CP_0961 - HOGENOM: HBG413852 - OMA: REIEVSC - PhylomeDB: Q9Z701 - ProtClustDB: PRK14573 - BioCyc: CPNE115711:CP_0961-MONOMER - BioCyc: CPNE115713:CPN0905-MONOMER - BioCyc: CPNE138677:CPJ0905-MONOMER - BioCyc: CPNE182082:CPB0937-MONOMER - BRENDA: 6.3.2.4 - BRENDA: 6.3.2.8 - GO: GO:0005737 - HAMAP: MF_00046 - HAMAP: MF_00047 - InterPro: IPR011761 - InterPro: IPR013815 - InterPro: IPR013816 - InterPro: IPR000291 - InterPro: IPR005905 - InterPro: IPR011095 - InterPro: IPR011127 - InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR016040 - InterPro: IPR013817 - InterPro: IPR016185 - InterPro: IPR005758 - Gene3D: G3DSA:3.30.1490.20 - Gene3D: G3DSA:3.30.470.20 - Gene3D: G3DSA:3.90.190.20 - Gene3D: G3DSA:3.40.1190.10 - Gene3D: G3DSA:3.40.50.720 - Gene3D: G3DSA:3.40.50.20 - TIGRFAMs: TIGR01205 - TIGRFAMs: TIGR01082
Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N; PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen; SSF52440 PreATP-grasp-like
EC number: =6.3.2.8; =6.3.2.4
Molecular weight: Translated: 89965; Mature: 89965
Theoretical pI: Translated: 5.78; Mature: 5.78
Prosite motif: PS50975 ATP_GRASP; PS00843 DALA_DALA_LIGASE_1; PS00844 DALA_DALA_LIGASE_2; PS00430 TONB_DEPENDENT_REC_1
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.3 %Cys (Translated Protein) 1.0 %Met (Translated Protein) 3.3 %Cys+Met (Translated Protein) 2.3 %Cys (Mature Protein) 1.0 %Met (Mature Protein) 3.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKGTPQYHFIGIGGIGMSALAHILLDRGYEVSGSDLYESYTIESLKAKGARCFSGHDSSH CCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCC VPHDAVVVYSSSIAPDNVEYLTAIQRSSRLLHRAELLSQLMEGYESILVSGSHGKTGTSS CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHH LIRAIFQEAQKDPSYAIGGLAANCLNGYSGSSKIFVAEADESDGSLKHYTPRAVVITNID HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECCCEEEEECCC NEHLNNYAGNLDNLVQVIQDFSRKVTDLNKVFYNGDCPILKGNVQGISYGYSPECQLHIV HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCEEECCCCCCEEEEEE SYNQKAWQSHFSFTFLGQEYQDIELNLPGQHNAANAAAACGVALTFGIDINIIRKALKKF ECCHHHHHHCCCEEEECCCCCEEEEECCCCCCCCHHHHHCCEEEEECCCHHHHHHHHHHH SGVHRRLERKNISESFLFLEDYAHHPVEVAHTLRSVRDAVGLRRVIAIFQPHRFSRLEEC HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH LQTFPKAFQEADEVILTDVYSAGESPRESIILSDLAEQIRKSSYVHCCYVPHGDIVDYLR HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH NYIRIHDVCVSLGAGNIYTIGEALKDFNPKKLSIGLVCGGKSCEHDISLLSAQHVSKYIS HHHHHHHHHHHCCCCCEEEHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCC PEFYDVSYFIINRQGLWRTGKDFPHLIEETQGDSPLSSEIASALAKVDCLFPVLHGPFGE CCEEEEEEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC DGTIQGFFEILGKPYAGPSLSLAATAMDKLLTKRIASAVGVPVVPYQPLNLCFWKRNPEL CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHH CIQNLIETFSFPMIVKTAHLGSSIGIFLVRDKEELQEKISEAFLYDTDVFVEESRLGSRE HHHHHHHHHCCCHHEEEHHCCCCCEEEEEECHHHHHHHHHHHHHCCCHHEEECCCCCCCE IEVSCIGHSSSWYCMAGPNERCGASGFIDYQEKYGFDGIDCAKISFDLQLSQESLDCVRE EEEEEEECCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEECHHHHHHHHH LAERVYRAMQGKGSARIDFFLDEEGNYWLSEVNPIPGMTAASPFLQAFVHAGWTQEQIVD HHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHH HFIIDALHKFDKQQTIEQAFTKEQDLVKR HHHHHHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MKGTPQYHFIGIGGIGMSALAHILLDRGYEVSGSDLYESYTIESLKAKGARCFSGHDSSH CCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCC VPHDAVVVYSSSIAPDNVEYLTAIQRSSRLLHRAELLSQLMEGYESILVSGSHGKTGTSS CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHH LIRAIFQEAQKDPSYAIGGLAANCLNGYSGSSKIFVAEADESDGSLKHYTPRAVVITNID HHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECCCEEEEECCC NEHLNNYAGNLDNLVQVIQDFSRKVTDLNKVFYNGDCPILKGNVQGISYGYSPECQLHIV HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCEEECCCCEEECCCCCCEEEEEE SYNQKAWQSHFSFTFLGQEYQDIELNLPGQHNAANAAAACGVALTFGIDINIIRKALKKF ECCHHHHHHCCCEEEECCCCCEEEEECCCCCCCCHHHHHCCEEEEECCCHHHHHHHHHHH SGVHRRLERKNISESFLFLEDYAHHPVEVAHTLRSVRDAVGLRRVIAIFQPHRFSRLEEC HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH LQTFPKAFQEADEVILTDVYSAGESPRESIILSDLAEQIRKSSYVHCCYVPHGDIVDYLR HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHH NYIRIHDVCVSLGAGNIYTIGEALKDFNPKKLSIGLVCGGKSCEHDISLLSAQHVSKYIS HHHHHHHHHHHCCCCCEEEHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHCC PEFYDVSYFIINRQGLWRTGKDFPHLIEETQGDSPLSSEIASALAKVDCLFPVLHGPFGE CCEEEEEEEEEECCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC DGTIQGFFEILGKPYAGPSLSLAATAMDKLLTKRIASAVGVPVVPYQPLNLCFWKRNPEL CCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHHH CIQNLIETFSFPMIVKTAHLGSSIGIFLVRDKEELQEKISEAFLYDTDVFVEESRLGSRE HHHHHHHHHCCCHHEEEHHCCCCCEEEEEECHHHHHHHHHHHHHCCCHHEEECCCCCCCE IEVSCIGHSSSWYCMAGPNERCGASGFIDYQEKYGFDGIDCAKISFDLQLSQESLDCVRE EEEEEEECCCCEEEECCCCCCCCCCCCCCCHHHCCCCCCEEEEEEEEEEECHHHHHHHHH LAERVYRAMQGKGSARIDFFLDEEGNYWLSEVNPIPGMTAASPFLQAFVHAGWTQEQIVD HHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCHHHHHH HFIIDALHKFDKQQTIEQAFTKEQDLVKR HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362