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Identifier: 15835683

GI number: 15835683

Start: 183557

End: 185416

Strand: Direct

Name: Not Available

Synonym: CPj0148

Alternate gene names: 15835683

Gene position: 183557-185416 (Clockwise)

Preceding gene: 15835682

Following gene: 15835684

Centisome position: 14.97

GC content: 40.65

Gene sequence:

>1860_bases
ATGGAAAGTGAGAAAGATATAGGAGCTAAGTTTTTAGGTGACTATAGGATTCTCTATCGCAAGGGGCAGAGCCTATGGAG
CGAAGATCTTTTAGCCGAACATCGATTTATAAAAAAACGTTACCTTATTCGATTACTTCTTCCTGATCTAGGAAGTTCTC
AACCATTCATGGAAGCTTTTCATGATGTTGTTGTTAAACTAGCAAAATTAAACCATCCAGGCATCCTCAGTATAGAAAAT
GTTTCTGAATCTGAGGGAAGATGTTTCTTGGTAACACAAGAGCAAGACATCCCCATCCTTTCACTAACGCAATATTTAAA
AAGTATTCCCCGCAAACTTACAGAGCTAGAAATTGTAGATATTGTAAGCCAACTCGCTTCTCTTTTAGATTATGTGCATT
CAGAAGGACTGGCTCAAGAAGAGTGGAATCTTGATTCTGTCTATATTCATATTTTGAATGGTGTTCCTAAAGTCATACTC
CCTGATCTGGGGTTTGCTTCATTGATAAAAGAACGTATTTTGGACGGGTTTATTTCAGATGAGGAGAATCGAGAATCTAA
AATAAAAGAAAGGGTACTACTTCACACTTCAGAAGGAAAACAAGGTAGAGAAGATACGTATGCTTTTGGTGCTATCACCT
ATTATTTACTTTTTGGTTTTCTTCCTCAAGGCATTTTCCCTATGCCTTCGAAAGTTTTTTCTGATTTTATCTATGATTGG
GATTTTTTAATTAGCTCTTGTTTAAGTTGTTTTATGGAAGAAAGGGCAAAAGAACTTTTCCCCTTAATAAGAAAAAAAAC
TTTAGGAGAAGAGCTGCAAAATGTTGTCACTAACTGTATAGAAAGCTCTTTAAGGGAAGTGCCAGATCCTTTGGAATCTT
CTCAGAATCTTCCTCAAGCGGTCCTTAAAGTAGGGGAAACGAAGGTAAGTCACCAGCAGAAGGAATCTGCGGAACATTTA
GAATTTGTGTTAGTGGAAGCATGCTCCATAGATGAAGCCATGGATACCGCTATAGAATCCGAAAGTAGTTCTGGAGTTGA
GGAGGAAGGGTATTCCCTAGCTCTACAGTCTTTATTAGTTCGGGAACCAGTAGTGAGTCGTTATGTAGAAGCTGAGAAAG
AAGAACCCAAACCGCAACCCATACTTACAGAAATGGTTTTAATAGAGGGAGGAGAATTCTCCCGAGGAAGTGTCGAAGGG
CAACGTGATGAGCTTCCTGTACATAAGGTAATTTTACATAGCTTTTTCTTAGATGTTCATCCTGTGACGAACGAACAGTT
TATTCGTTATTTAGAATGTTGTGGTAGTGAACAGGATAAGTATTATAATGAGTTAATCCGATTGCGAGATTCTCGTATAC
AGCGTCGTTCGGGTAGGCTTGTTATAGAGCCAGGTTATGCTAAGCACCCTGTCGTTGGGGTTACTTGGTATGGAGCCTCA
GGGTATGCAGAATGGATAGGAAAACGCCTGCCTACAGAAGCTGAATGGGAAATAGCTGCTTCTGGCGGGGTGGCTGCGCT
ACGCTATCCCTGTGGGGAGGAAATCGAAAAAAGCCGGGCAAATTTTTTCACTGCGGATACGACAACAGTCATGAGTTATC
CACCCAATCCTTATGGCCTCTATGATATGGCAGGGAATGTCTACGAGTGGTGCCAAGATTGGTATGGGTATGATTTTTAT
GAAATTTCTGCTCAAGAGCCAGAGAGTCCTCAAGGTCCTGCTCAAGGAGTCTATCGGGTGCTAAGAGGGGGATGTTGGAA
GAGCTTAAAAGATGATCTTCGCTGTGCTCATCGCCATCGTAATAATCCTGGGGCTGTAAATAGTACGTATGGTTTTAGGT
GCGCTAAAAATATCAATTAA

Upstream 100 bases:

>100_bases
AAGAATAACTAGAGGTTCTTGTTTGTTTATTGCAATCTTCGTTTTTGCTATCTATAGTTAACTTATATAAATATAAGGCA
AATGGTGGAGAGTTAGCTCT

Downstream 100 bases:

>100_bases
GAGAGGTTCATGAAGGAAGAGAATTCACAAGCACACTACTTAGCTTTATGTCGTGAATTAGAAGACCATGATTATTCTTA
TTATGTGTTGCATCGTCCTA

Product: S/T protein kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MESEKDIGAKFLGDYRILYRKGQSLWSEDLLAEHRFIKKRYLIRLLLPDLGSSQPFMEAFHDVVVKLAKLNHPGILSIEN
VSESEGRCFLVTQEQDIPILSLTQYLKSIPRKLTELEIVDIVSQLASLLDYVHSEGLAQEEWNLDSVYIHILNGVPKVIL
PDLGFASLIKERILDGFISDEENRESKIKERVLLHTSEGKQGREDTYAFGAITYYLLFGFLPQGIFPMPSKVFSDFIYDW
DFLISSCLSCFMEERAKELFPLIRKKTLGEELQNVVTNCIESSLREVPDPLESSQNLPQAVLKVGETKVSHQQKESAEHL
EFVLVEACSIDEAMDTAIESESSSGVEEEGYSLALQSLLVREPVVSRYVEAEKEEPKPQPILTEMVLIEGGEFSRGSVEG
QRDELPVHKVILHSFFLDVHPVTNEQFIRYLECCGSEQDKYYNELIRLRDSRIQRRSGRLVIEPGYAKHPVVGVTWYGAS
GYAEWIGKRLPTEAEWEIAASGGVAALRYPCGEEIEKSRANFFTADTTTVMSYPPNPYGLYDMAGNVYEWCQDWYGYDFY
EISAQEPESPQGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKNIN

Sequences:

>Translated_619_residues
MESEKDIGAKFLGDYRILYRKGQSLWSEDLLAEHRFIKKRYLIRLLLPDLGSSQPFMEAFHDVVVKLAKLNHPGILSIEN
VSESEGRCFLVTQEQDIPILSLTQYLKSIPRKLTELEIVDIVSQLASLLDYVHSEGLAQEEWNLDSVYIHILNGVPKVIL
PDLGFASLIKERILDGFISDEENRESKIKERVLLHTSEGKQGREDTYAFGAITYYLLFGFLPQGIFPMPSKVFSDFIYDW
DFLISSCLSCFMEERAKELFPLIRKKTLGEELQNVVTNCIESSLREVPDPLESSQNLPQAVLKVGETKVSHQQKESAEHL
EFVLVEACSIDEAMDTAIESESSSGVEEEGYSLALQSLLVREPVVSRYVEAEKEEPKPQPILTEMVLIEGGEFSRGSVEG
QRDELPVHKVILHSFFLDVHPVTNEQFIRYLECCGSEQDKYYNELIRLRDSRIQRRSGRLVIEPGYAKHPVVGVTWYGAS
GYAEWIGKRLPTEAEWEIAASGGVAALRYPCGEEIEKSRANFFTADTTTVMSYPPNPYGLYDMAGNVYEWCQDWYGYDFY
EISAQEPESPQGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKNIN
>Mature_619_residues
MESEKDIGAKFLGDYRILYRKGQSLWSEDLLAEHRFIKKRYLIRLLLPDLGSSQPFMEAFHDVVVKLAKLNHPGILSIEN
VSESEGRCFLVTQEQDIPILSLTQYLKSIPRKLTELEIVDIVSQLASLLDYVHSEGLAQEEWNLDSVYIHILNGVPKVIL
PDLGFASLIKERILDGFISDEENRESKIKERVLLHTSEGKQGREDTYAFGAITYYLLFGFLPQGIFPMPSKVFSDFIYDW
DFLISSCLSCFMEERAKELFPLIRKKTLGEELQNVVTNCIESSLREVPDPLESSQNLPQAVLKVGETKVSHQQKESAEHL
EFVLVEACSIDEAMDTAIESESSSGVEEEGYSLALQSLLVREPVVSRYVEAEKEEPKPQPILTEMVLIEGGEFSRGSVEG
QRDELPVHKVILHSFFLDVHPVTNEQFIRYLECCGSEQDKYYNELIRLRDSRIQRRSGRLVIEPGYAKHPVVGVTWYGAS
GYAEWIGKRLPTEAEWEIAASGGVAALRYPCGEEIEKSRANFFTADTTTVMSYPPNPYGLYDMAGNVYEWCQDWYGYDFY
EISAQEPESPQGPAQGVYRVLRGGCWKSLKDDLRCAHRHRNNPGAVNSTYGFRCAKNIN

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth

COG id: COG0515

COG function: function code RTKL; Serine/threonine protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain

Homologues:

Organism=Homo sapiens, GI257470975, Length=279, Percent_Identity=31.1827956989247, Blast_Score=128, Evalue=2e-29,
Organism=Homo sapiens, GI38202250, Length=299, Percent_Identity=29.0969899665552, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI194248087, Length=277, Percent_Identity=30.3249097472924, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI194248088, Length=282, Percent_Identity=30.1418439716312, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI257470977, Length=296, Percent_Identity=27.027027027027, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI226437577, Length=169, Percent_Identity=34.9112426035503, Blast_Score=93, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20130397, Length=288, Percent_Identity=28.8194444444444, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PKN1_CHLPN (Q7AJA5)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   A72114
- PIR:   D81556
- PIR:   D86509
- RefSeq:   NP_224356.1
- RefSeq:   NP_300207.1
- RefSeq:   NP_445167.1
- RefSeq:   NP_876425.1
- ProteinModelPortal:   Q7AJA5
- SMR:   Q7AJA5
- GeneID:   1466832
- GeneID:   894945
- GeneID:   918939
- GeneID:   963272
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0625
- KEGG:   cpj:CPj0148
- KEGG:   cpn:CPn0148
- KEGG:   cpt:CpB0149
- TIGR:   CP_0625
- HOGENOM:   HBG413964
- OMA:   YYNELIR
- ProtClustDB:   CLSK871217
- BioCyc:   CPNE115711:CP_0625-MONOMER
- BioCyc:   CPNE115713:CPN0148-MONOMER
- BioCyc:   CPNE138677:CPJ0148-MONOMER
- BioCyc:   CPNE182082:CPB0149-MONOMER
- BRENDA:   2.7.11.1
- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532
- Gene3D:   G3DSA:3.90.1580.10

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase; SSF56436 C-type_lectin_fold; SSF56112 Kinase_like

EC number: =2.7.11.1

Molecular weight: Translated: 70356; Mature: 70356

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: ACT_SITE 141-141

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESEKDIGAKFLGDYRILYRKGQSLWSEDLLAEHRFIKKRYLIRLLLPDLGSSQPFMEAF
CCCCHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HDVVVKLAKLNHPGILSIENVSESEGRCFLVTQEQDIPILSLTQYLKSIPRKLTELEIVD
HHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IVSQLASLLDYVHSEGLAQEEWNLDSVYIHILNGVPKVILPDLGFASLIKERILDGFISD
HHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCC
EENRESKIKERVLLHTSEGKQGREDTYAFGAITYYLLFGFLPQGIFPMPSKVFSDFIYDW
CCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
DFLISSCLSCFMEERAKELFPLIRKKTLGEELQNVVTNCIESSLREVPDPLESSQNLPQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHH
VLKVGETKVSHQQKESAEHLEFVLVEACSIDEAMDTAIESESSSGVEEEGYSLALQSLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
REPVVSRYVEAEKEEPKPQPILTEMVLIEGGEFSRGSVEGQRDELPVHKVILHSFFLDVH
HHHHHHHHHHHHCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PVTNEQFIRYLECCGSEQDKYYNELIRLRDSRIQRRSGRLVIEPGYAKHPVVGVTWYGAS
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCC
GYAEWIGKRLPTEAEWEIAASGGVAALRYPCGEEIEKSRANFFTADTTTVMSYPPNPYGL
CHHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHCCEEECCCEEEEECCCCCCCH
YDMAGNVYEWCQDWYGYDFYEISAQEPESPQGPAQGVYRVLRGGCWKSLKDDLRCAHRHR
HHHCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NNPGAVNSTYGFRCAKNIN
CCCCCCCCCCCCEECCCCC
>Mature Secondary Structure
MESEKDIGAKFLGDYRILYRKGQSLWSEDLLAEHRFIKKRYLIRLLLPDLGSSQPFMEAF
CCCCHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
HDVVVKLAKLNHPGILSIENVSESEGRCFLVTQEQDIPILSLTQYLKSIPRKLTELEIVD
HHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
IVSQLASLLDYVHSEGLAQEEWNLDSVYIHILNGVPKVILPDLGFASLIKERILDGFISD
HHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCC
EENRESKIKERVLLHTSEGKQGREDTYAFGAITYYLLFGFLPQGIFPMPSKVFSDFIYDW
CCHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
DFLISSCLSCFMEERAKELFPLIRKKTLGEELQNVVTNCIESSLREVPDPLESSQNLPQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHH
VLKVGETKVSHQQKESAEHLEFVLVEACSIDEAMDTAIESESSSGVEEEGYSLALQSLLV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
REPVVSRYVEAEKEEPKPQPILTEMVLIEGGEFSRGSVEGQRDELPVHKVILHSFFLDVH
HHHHHHHHHHHHCCCCCCCCHHHHHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
PVTNEQFIRYLECCGSEQDKYYNELIRLRDSRIQRRSGRLVIEPGYAKHPVVGVTWYGAS
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEEECCC
GYAEWIGKRLPTEAEWEIAASGGVAALRYPCGEEIEKSRANFFTADTTTVMSYPPNPYGL
CHHHHHHHHCCCCCCEEEECCCCEEEEECCCCHHHHHHHCCEEECCCEEEEECCCCCCCH
YDMAGNVYEWCQDWYGYDFYEISAQEPESPQGPAQGVYRVLRGGCWKSLKDDLRCAHRHR
HHHCCCHHHHHHHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NNPGAVNSTYGFRCAKNIN
CCCCCCCCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362