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The map label for this gene is groEL

Identifier: 15835669

GI number: 15835669

Start: 167175

End: 168809

Strand: Reverse

Name: groEL

Synonym: CPj0134

Alternate gene names: 15835669

Gene position: 168809-167175 (Counterclockwise)

Preceding gene: 15835670

Following gene: 15835668

Centisome position: 13.76

GC content: 41.35

Gene sequence:

>1635_bases
ATGGCAGCGAAAAATATTAAATATAATGAAGAAGCCAGAAAAAAAATACATAAAGGGGTAAAAACTCTTGCAGAAGCAGT
AAAAGTTACTCTAGGTCCTAAAGGACGTCACGTAGTTATAGATAAGAGCTTTGGCTCTCCCCAAGTGACTAAAGATGGTG
TTACTGTAGCTAAAGAAATCGAGCTCGAAGACAAACATGAAAACATGGGCGCTCAGATGGTAAAAGAAGTCGCCAGCAAA
ACTGCTGACAAAGCAGGCGACGGAACTACAACAGCAACTGTTCTTGCAGAAGCAATCTATAGCGAAGGTCTAAGAAATGT
CACTGCCGGTGCCAATCCTATGGACCTAAAAAGAGGTATCGACAAAGCCGTAAAAGTTGTTGTTGATGAACTCAAAAAAA
TTAGTAAACCTGTACAACATCACAAAGAAATCGCTCAAGTAGCTACTATCTCAGCAAATAATGATTCCGAAATCGGAAAT
CTTATTGCAGAAGCTATGGAAAAAGTTGGTAAAAACGGATCCATTACTGTTGAAGAAGCTAAAGGCTTCGAAACTGTTCT
CGACGTTGTAGAAGGAATGAACTTCAACCGTGGATACCTCTCCAGCTACTTCTCCACAAATCCAGAAACTCAAGAATGCG
TTTTAGAAGACGCTCTGATTCTAATCTACGATAAAAAAATCTCTGGAATTAAAGACTTCCTTCCAGTTTTACAACAAGTA
GCAGAATCTGGACGCCCTCTTTTAATCATTGCAGAAGAAATTGAAGGAGAAGCTTTAGCAACTCTAGTAGTCAATAGACT
CCGTGCAGGATTCAGAGTCTGTGCAGTGAAAGCTCCTGGTTTCGGTGACAGAAGAAAAGCTATGTTAGAAGACATCGCTA
TCCTTACTGGTGGCCAACTAGTTAGCGAAGAACTTGGCATGAAACTAGAGAATACAACTCTAGCAATGTTAGGAAAAGCT
AAGAAAGTTATCGTAACTAAAGAAGATACCACAATCGTCGAAGGCTTAGGAAACAAACCTGATATCCAAGCTCGATGCGA
CAATATTAAAAAACAAATCGAAGATAGCACTTCAGATTACGACAAAGAAAAACTCCAAGAGCGTTTAGCTAAACTCTCCG
GTGGTGTCGCCGTAATCCGCGTAGGAGCTGCTACCGAAATAGAGATGAAAGAGAAAAAAGACAGAGTAGATGATGCACAA
CACGCAACCATTGCAGCTGTCGAAGAAGGAATCCTCCCTGGTGGTGGAACTGCCTTAGTTCGCTGTATCCCTACACTAGA
AGCTTTCCTTCCTATGCTAGCAAACGAAGACGAAGCTATTGGTACTCGTATTATTCTAAAAGCATTAACAGCTCCATTAA
AGCAAATTGCAAGTAACGCAGGTAAAGAAGGCGCTATCATTTGTCAGCAAGTTCTAGCAAGATCTGCAAATGAAGGCTAT
GATGCTTTACGTGACGCTTATACAGATATGATTGACGCAGGAATTTTAGATCCAACTAAAGTGACTCGCTCAGCTCTAGA
AAGCGCAGCTTCTATCGCAGGATTACTCCTCACAACAGAAGCCTTAATCGCTGATATCCCAGAAGAGAAATCTTCTTCAG
CTCCAGCGATGCCAAGCGCAGGAATGGACTACTAG

Upstream 100 bases:

>100_bases
TCGATGACGAAGAGTATGTCATTCTACAGTCCAGTGAAATCATGGCCGTCCTAAAATAAAATACTAGTTTGCAGATTATA
GAAAGTTAAGGAGAACAACG

Downstream 100 bases:

>100_bases
TCTCTTAAGCTAGTATTAACAATTTTCCATGAGGTCTCTTTTCTAACTAAAGAAAAGAGACCTTTTTCTTTGGGAATATT
CATTTCTTAATCTATCTTAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: 57 kDa chlamydial hypersensitivity antigen; GroEL protein 1; Protein Cpn60 1 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKA
KKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQ
HATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGY
DALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY

Sequences:

>Translated_544_residues
MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASK
TADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGN
LIAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQV
AESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKA
KKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQ
HATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGY
DALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY
>Mature_543_residues
AAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEIELEDKHENMGAQMVKEVASKT
ADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGIDKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNL
IAEAMEKVGKNGSITVEEAKGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQVA
ESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQLVSEELGMKLENTTLAMLGKAK
KVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDYDKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQH
ATIAAVEEGILPGGGTALVRCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGYD
ALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSAGMDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. This protein is implicated in the pathogenesis of chlamydial disease. Inflammation elicited by the 57 kDa antigen may damage tis

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=52.3629489603025, Blast_Score=546, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=52.3629489603025, Blast_Score=546, Evalue=1e-155,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=62.0300751879699, Blast_Score=658, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=531, Percent_Identity=51.0357815442561, Blast_Score=528, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI193210679, Length=213, Percent_Identity=51.6431924882629, Blast_Score=210, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.9429657794677, Blast_Score=548, Evalue=1e-157,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=26.5432098765432, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=52.0833333333333, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=52.0833333333333, Blast_Score=552, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=49.7164461247637, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=49.7164461247637, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=49.7164461247637, Blast_Score=526, Evalue=1e-149,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=43.1192660550459, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=538, Percent_Identity=36.9888475836431, Blast_Score=335, Evalue=5e-92,
Organism=Drosophila melanogaster, GI19921262, Length=538, Percent_Identity=36.9888475836431, Blast_Score=335, Evalue=5e-92,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58205; Mature: 58073

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDY
HHHHHCCEECCCHHHHHCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALV
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
DALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDY
CCCC
>Mature Secondary Structure 
AAKNIKYNEEARKKIHKGVKTLAEAVKVTLGPKGRHVVIDKSFGSPQVTKDGVTVAKEI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHC
ELEDKHENMGAQMVKEVASKTADKAGDGTTTATVLAEAIYSEGLRNVTAGANPMDLKRGI
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
DKAVKVVVDELKKISKPVQHHKEIAQVATISANNDSEIGNLIAEAMEKVGKNGSITVEEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHH
KGFETVLDVVEGMNFNRGYLSSYFSTNPETQECVLEDALILIYDKKISGIKDFLPVLQQV
CCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHCCEEEEECCHHCCHHHHHHHHHHH
AESGRPLLIIAEEIEGEALATLVVNRLRAGFRVCAVKAPGFGDRRKAMLEDIAILTGGQL
HHCCCCEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHH
VSEELGMKLENTTLAMLGKAKKVIVTKEDTTIVEGLGNKPDIQARCDNIKKQIEDSTSDY
HHHHHCCEECCCHHHHHCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHCCCCCC
DKEKLQERLAKLSGGVAVIRVGAATEIEMKEKKDRVDDAQHATIAAVEEGILPGGGTALV
CHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHH
RCIPTLEAFLPMLANEDEAIGTRIILKALTAPLKQIASNAGKEGAIICQQVLARSANEGY
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCH
DALRDAYTDMIDAGILDPTKVTRSALESAASIAGLLLTTEALIADIPEEKSSSAPAMPSA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
GMDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2571668; 12682364 [H]