Click here to switch to the map view.

The map label for this gene is mrsA

Identifier: 15835592

GI number: 15835592

Start: 70629

End: 72425

Strand: Direct

Name: mrsA

Synonym: CPj0056

Alternate gene names: 15835592

Gene position: 70629-72425 (Clockwise)

Preceding gene: 15835591

Following gene: 15835593

Centisome position: 5.76

GC content: 43.13

Gene sequence:

>1797_bases
ATGAAAGAAGTAGAACAACGTATCCGGTCATTATACGATGCAGTAACAGCTGAAAATATTTGTAGATGGTTGTCCAATGA
TTGTACCCAACAAGATGCAAAGACTATCCTAGGATGGTTAGATACAGATCCTGCACAGCTTGAAGATCTATTCGGAGCGA
CTCTTACCTTTGGTACCGGAGGACTCCGTAGTCTTATGGGTATCGGAACAAATAGGATCAACCTGTTTACTATACGTCGA
ACGACGCAAGGGCTGGTTCAGGTGCTCCGCGCTCATCTTCCCCATCCCGGAGATCCTATGCGTGTAGTTGTCGGTTGTGA
TACCCGCCATAACTCTATAGAATTTGCTCAAGAAACTGCAAAAGTCCTCGCAGGTAATGGCTGCGAAGTTTTCTTGTTTC
AGTATCCCGAACCTTTGGCTTTAGTCTCCTTTACGGTGAGATACGAAAGGGCCATCGGCGGAGTGATGATCACCGCCTCT
CATAATCCTCCCAATTACAATGGGTATAAAGTTTATATGGCTTCGGGAGGCCAAGTTCTCCCTCCCTTAGATCAAGAGAT
TGTTGCCGCCTGTAGTGCAGTGAACGAAATTTTATCAGTGCCCTCGATAGATCATCCCAATATTCACCTCATTGGAAAAG
AATACGAAGCCCTTTACAGAGACACTTTGAAGCAACTGCAACTCTATCCCGAAGCAAACCGGATTTCAGGAAGGTCTTTA
TCTATTTCCTATTCGCCATTGCATGGAACAGGAATTTCTCTCGTTCCTCATGTTCTCAAAGACTGGGGATTTTTATCCGT
ACATCTTGTGGAAAAACAGGCCATAGGTGACGGCGATTTCCCAACCGTGCAGCTGCCAAATCCTGAGGATCCAGAGGCTC
TGACTCTGGGCACTGAGCAAATGCTCGCTAATGACGATGATCTTTTTATAGCTACCGACCCAGATGCCGATCGCGTGGGC
GTGGTTTGTCTAGAAGACGGCCAACCCTACCGATTTAACGGAAATCAAATGGCGAGCCTTTTAGCAGACCACATCTTAGG
AGCTTGGAGCAAAACAAGACACTTAGGAGAACATGATAAATTGGTCAAGAGCTTGGTGACTACAGAAATGCTCTCTGCTA
TCGCAAAGCACTATCATGTGGATCTTATTAATGTCGGAACAGGATTTAAATACATCGGAGAGAAAATTGAATCCTGGCGC
AATTCCACAAACAAATTCGTATTTGGAGCCGAGGAATCTTACGGTTGTCTCTACGGCACTCACGTAGAAGATAAAGACGC
TATTATTGCGTCAGCATTGATTGCAGAAGCCGCACTACAACAAAAATTACAAGGAAAAACTCTATGCGACGCACTCCTTT
CTCTTTACGAAACATACGGATACTTTGCTAACAAAACGGAGTCTGTGGTTTTTTCCGCAAAAACTGACGAACAAGAAATA
AGAAAAAAACTTTCACACCTTGAGGAAATCAGTTCTGCGAATTTTTTCTCAGGGAAATACCAAGTAGAGAAATTTGAAAA
CTATAAGCAAGGGATAGGTTTCAATCTTCTATCGAAGGATTCCTACGCCCTCACCCTGCCTAAAACATCTATGCTCTGTT
ATTATTTTAGTGGGGGAGGTCGGGTAATCATACGACCCTCAGGAACAGAACCTAAAATCAAGTTCTACTTCGAAATGTCA
ACTCATTATCCAGAGCGCGTTACCGATAAAGAAATACAAAAACAACGTGAAGCAGAGAGTTTTCAACATTTAGACGATTT
TATTTTTGATTTTAAAGAGAAATTTTCCAATTTGTGA

Upstream 100 bases:

>100_bases
AAACAATGGATTATACCAGACCAAGCTTGAAGAATCCCTGGACTTTATGCAAAAAGGGTGTTAAGAGTTCCTGAAACTAT
CCTTACATAGGATTTCTTTA

Downstream 100 bases:

>100_bases
GTGGAAAAATCATCTTGGAGAATATCCTAAAGCTATTTACACTTGGGCTAAATCTCCTTCAGAATAAGGCCTTCTTTCAA
GGCCATTGTTGTATCCGAAA

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 598; Mature: 598

Protein sequence:

>598_residues
MKEVEQRIRSLYDAVTAENICRWLSNDCTQQDAKTILGWLDTDPAQLEDLFGATLTFGTGGLRSLMGIGTNRINLFTIRR
TTQGLVQVLRAHLPHPGDPMRVVVGCDTRHNSIEFAQETAKVLAGNGCEVFLFQYPEPLALVSFTVRYERAIGGVMITAS
HNPPNYNGYKVYMASGGQVLPPLDQEIVAACSAVNEILSVPSIDHPNIHLIGKEYEALYRDTLKQLQLYPEANRISGRSL
SISYSPLHGTGISLVPHVLKDWGFLSVHLVEKQAIGDGDFPTVQLPNPEDPEALTLGTEQMLANDDDLFIATDPDADRVG
VVCLEDGQPYRFNGNQMASLLADHILGAWSKTRHLGEHDKLVKSLVTTEMLSAIAKHYHVDLINVGTGFKYIGEKIESWR
NSTNKFVFGAEESYGCLYGTHVEDKDAIIASALIAEAALQQKLQGKTLCDALLSLYETYGYFANKTESVVFSAKTDEQEI
RKKLSHLEEISSANFFSGKYQVEKFENYKQGIGFNLLSKDSYALTLPKTSMLCYYFSGGGRVIIRPSGTEPKIKFYFEMS
THYPERVTDKEIQKQREAESFQHLDDFIFDFKEKFSNL

Sequences:

>Translated_598_residues
MKEVEQRIRSLYDAVTAENICRWLSNDCTQQDAKTILGWLDTDPAQLEDLFGATLTFGTGGLRSLMGIGTNRINLFTIRR
TTQGLVQVLRAHLPHPGDPMRVVVGCDTRHNSIEFAQETAKVLAGNGCEVFLFQYPEPLALVSFTVRYERAIGGVMITAS
HNPPNYNGYKVYMASGGQVLPPLDQEIVAACSAVNEILSVPSIDHPNIHLIGKEYEALYRDTLKQLQLYPEANRISGRSL
SISYSPLHGTGISLVPHVLKDWGFLSVHLVEKQAIGDGDFPTVQLPNPEDPEALTLGTEQMLANDDDLFIATDPDADRVG
VVCLEDGQPYRFNGNQMASLLADHILGAWSKTRHLGEHDKLVKSLVTTEMLSAIAKHYHVDLINVGTGFKYIGEKIESWR
NSTNKFVFGAEESYGCLYGTHVEDKDAIIASALIAEAALQQKLQGKTLCDALLSLYETYGYFANKTESVVFSAKTDEQEI
RKKLSHLEEISSANFFSGKYQVEKFENYKQGIGFNLLSKDSYALTLPKTSMLCYYFSGGGRVIIRPSGTEPKIKFYFEMS
THYPERVTDKEIQKQREAESFQHLDDFIFDFKEKFSNL
>Mature_598_residues
MKEVEQRIRSLYDAVTAENICRWLSNDCTQQDAKTILGWLDTDPAQLEDLFGATLTFGTGGLRSLMGIGTNRINLFTIRR
TTQGLVQVLRAHLPHPGDPMRVVVGCDTRHNSIEFAQETAKVLAGNGCEVFLFQYPEPLALVSFTVRYERAIGGVMITAS
HNPPNYNGYKVYMASGGQVLPPLDQEIVAACSAVNEILSVPSIDHPNIHLIGKEYEALYRDTLKQLQLYPEANRISGRSL
SISYSPLHGTGISLVPHVLKDWGFLSVHLVEKQAIGDGDFPTVQLPNPEDPEALTLGTEQMLANDDDLFIATDPDADRVG
VVCLEDGQPYRFNGNQMASLLADHILGAWSKTRHLGEHDKLVKSLVTTEMLSAIAKHYHVDLINVGTGFKYIGEKIESWR
NSTNKFVFGAEESYGCLYGTHVEDKDAIIASALIAEAALQQKLQGKTLCDALLSLYETYGYFANKTESVVFSAKTDEQEI
RKKLSHLEEISSANFFSGKYQVEKFENYKQGIGFNLLSKDSYALTLPKTSMLCYYFSGGGRVIIRPSGTEPKIKFYFEMS
THYPERVTDKEIQKQREAESFQHLDDFIFDFKEKFSNL

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=561, Percent_Identity=31.3725490196078, Blast_Score=232, Evalue=8e-61,
Organism=Homo sapiens, GI63055049, Length=595, Percent_Identity=29.2436974789916, Blast_Score=231, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71993870, Length=565, Percent_Identity=30.9734513274336, Blast_Score=210, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71993878, Length=311, Percent_Identity=32.1543408360129, Blast_Score=134, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323934, Length=596, Percent_Identity=27.6845637583893, Blast_Score=183, Evalue=9e-47,
Organism=Drosophila melanogaster, GI20129809, Length=576, Percent_Identity=32.2916666666667, Blast_Score=236, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24651977, Length=554, Percent_Identity=31.4079422382672, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI24653722, Length=568, Percent_Identity=28.5211267605634, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 66820; Mature: 66820

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVEQRIRSLYDAVTAENICRWLSNDCTQQDAKTILGWLDTDPAQLEDLFGATLTFGTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEECCC
GLRSLMGIGTNRINLFTIRRTTQGLVQVLRAHLPHPGDPMRVVVGCDTRHNSIEFAQETA
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
KVLAGNGCEVFLFQYPEPLALVSFTVRYERAIGGVMITASHNPPNYNGYKVYMASGGQVL
HHHCCCCCEEEEEECCCCEEEHEEHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCC
PPLDQEIVAACSAVNEILSVPSIDHPNIHLIGKEYEALYRDTLKQLQLYPEANRISGRSL
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEE
SISYSPLHGTGISLVPHVLKDWGFLSVHLVEKQAIGDGDFPTVQLPNPEDPEALTLGTEQ
EEEECCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCEEECCCCCCCCEEEECHHH
MLANDDDLFIATDPDADRVGVVCLEDGQPYRFNGNQMASLLADHILGAWSKTRHLGEHDK
HHCCCCCEEEEECCCCCCEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHCCHHHH
LVKSLVTTEMLSAIAKHYHVDLINVGTGFKYIGEKIESWRNSTNKFVFGAEESYGCLYGT
HHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEC
HVEDKDAIIASALIAEAALQQKLQGKTLCDALLSLYETYGYFANKTESVVFSAKTDEQEI
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
RKKLSHLEEISSANFFSGKYQVEKFENYKQGIGFNLLSKDSYALTLPKTSMLCYYFSGGG
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEECCCCEEEEECCCEEEEEEEECCC
RVIIRPSGTEPKIKFYFEMSTHYPERVTDKEIQKQREAESFQHLDDFIFDFKEKFSNL
EEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEVEQRIRSLYDAVTAENICRWLSNDCTQQDAKTILGWLDTDPAQLEDLFGATLTFGTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHCCCEEECCC
GLRSLMGIGTNRINLFTIRRTTQGLVQVLRAHLPHPGDPMRVVVGCDTRHNSIEFAQETA
HHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHH
KVLAGNGCEVFLFQYPEPLALVSFTVRYERAIGGVMITASHNPPNYNGYKVYMASGGQVL
HHHCCCCCEEEEEECCCCEEEHEEHHHHHHHHCCEEEEECCCCCCCCCEEEEEECCCCCC
PPLDQEIVAACSAVNEILSVPSIDHPNIHLIGKEYEALYRDTLKQLQLYPEANRISGRSL
CCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCEE
SISYSPLHGTGISLVPHVLKDWGFLSVHLVEKQAIGDGDFPTVQLPNPEDPEALTLGTEQ
EEEECCCCCCCHHHHHHHHHCCCCEEEEEEEHHHCCCCCCCEEECCCCCCCCEEEECHHH
MLANDDDLFIATDPDADRVGVVCLEDGQPYRFNGNQMASLLADHILGAWSKTRHLGEHDK
HHCCCCCEEEEECCCCCCEEEEEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHCCHHHH
LVKSLVTTEMLSAIAKHYHVDLINVGTGFKYIGEKIESWRNSTNKFVFGAEESYGCLYGT
HHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEC
HVEDKDAIIASALIAEAALQQKLQGKTLCDALLSLYETYGYFANKTESVVFSAKTDEQEI
CCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
RKKLSHLEEISSANFFSGKYQVEKFENYKQGIGFNLLSKDSYALTLPKTSMLCYYFSGGG
HHHHHHHHHHHCCCCCCCCEEHHHHHHHHHCCCCEEECCCCEEEEECCCEEEEEEEECCC
RVIIRPSGTEPKIKFYFEMSTHYPERVTDKEIQKQREAESFQHLDDFIFDFKEKFSNL
EEEEECCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]