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Identifier: 16752301

GI number: 16752301

Start: 5537

End: 6724

Strand: Direct

Name: Not Available

Synonym: CP0005

Alternate gene names: 16752301

Gene position: 5537-6724 (Clockwise)

Preceding gene: 16752300

Following gene: 16752302

Centisome position: 0.45

GC content: 38.22

Gene sequence:

>1188_bases
ATGAGTTTTTTTAATCACATACCAACATTTTCTCCGGATGCTATTTTAGGTTTGCAGAACGTTTTCTTTGCAGATAAGCG
TCCCGAAAAGGTTAACCTTGTGATTGGTGTTTATGAGCATCCGCAAAAGCGTTACGGCGGCTTGTCTTGTATACGTAAGG
CACAAACTGTCATTTTGGAAGAAGAACAAAATAAGAGTTATCTTCCTATTTCAGGGTTGCAAATATTTTTAGATGAGATG
CGTGAGCTGGTTTTTGGTGCTGTAGATCCGAGTGCTATAGTCGGGTTTCAGTCTTTAGGAGGTACAGGAGCGCTACACTT
GGGAGCCCGGCTTCTTTCCGTGGCAAAAGGATCTGGTAAGGTTTATGTTCCCGAGCAGACTTGGAGCAATCATATACGCA
TTTTCTCTCAAGAGGGTCTTGAGGTAATCCGATATCCTTATTATAGCAAAGAACAAAAACAGCTGTTATTTGAACCCCTG
ATCGCATTTTTGAAGGAAGTAGAAAAGAATTCCGTTATCTTATTGCATGGTTGTTGTCACAACCCTACAGGTGTAGATTT
TACTGAAGATATGTGGAAAGAACTCGCCATCTTAATGAAAGAAAGAGAGTTAATTCCATTTTTTGATACCGCATACCAAG
GTTTTGCTCACGGCATAGAGTTGGATAGAAAACCTATAGAAATTTTTATATCAGAGGGAAATACGGTTCTTGTCGCTGCT
TCATCAAGCAAAAACTTTGCTCTTTATGGTGAGCGTGTAGGATATTTTGCTGTTCACAGTACTTTTACTGATGAGTTGGT
TAAAATTCACAGTTTCTTAGAAGAAAAAATTCGAGGGGAATACTCTTCACCACAACGTTGGGGTGTAGAAATTGTTTCTA
CAATTTTGAGTAATCCATATTTGAAAGAAGAATGGCAATCAGAACTCAATTTTATAAGAGAGTCTTTGGGTAAAATGAGA
ACAAGATTTGTTCAAGCTTTGCGTAAGGTTGCCGGTCATACATTTGACTTTTTATTGTCCCAACATGGATTCTTTGCATA
CCCTGGGTTTTCCGATAAACAGGTGCTCTTTTTAAGAGAACAACACGCTGTTTATACAACAGCGGGAGGAAGAATGAATT
TAAATGGAATTACGGAAAAAAATATAGATCATGTAGTGCAAAGTTTTATTCAAGCTTATGAGCTATAG

Upstream 100 bases:

>100_bases
GTTGCGCTCTACCAACTGAGCTAATACCCCAAAAGATACAAAAAAGTATCATGTTCCAGGGTTTAGAATCAATCTTTGTT
ATAATTAGGTGTAGTCATAT

Downstream 100 bases:

>100_bases
CCTACGCAATAAAAAAACAAAAATCTGCGTCTATATTATTATTGCTTTAGGGATTCTCTCTTTTCGAAGCATCCCTCAAG
AGGTCTATGATAAGATCAGA

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 395; Mature: 394

Protein sequence:

>395_residues
MSFFNHIPTFSPDAILGLQNVFFADKRPEKVNLVIGVYEHPQKRYGGLSCIRKAQTVILEEEQNKSYLPISGLQIFLDEM
RELVFGAVDPSAIVGFQSLGGTGALHLGARLLSVAKGSGKVYVPEQTWSNHIRIFSQEGLEVIRYPYYSKEQKQLLFEPL
IAFLKEVEKNSVILLHGCCHNPTGVDFTEDMWKELAILMKERELIPFFDTAYQGFAHGIELDRKPIEIFISEGNTVLVAA
SSSKNFALYGERVGYFAVHSTFTDELVKIHSFLEEKIRGEYSSPQRWGVEIVSTILSNPYLKEEWQSELNFIRESLGKMR
TRFVQALRKVAGHTFDFLLSQHGFFAYPGFSDKQVLFLREQHAVYTTAGGRMNLNGITEKNIDHVVQSFIQAYEL

Sequences:

>Translated_395_residues
MSFFNHIPTFSPDAILGLQNVFFADKRPEKVNLVIGVYEHPQKRYGGLSCIRKAQTVILEEEQNKSYLPISGLQIFLDEM
RELVFGAVDPSAIVGFQSLGGTGALHLGARLLSVAKGSGKVYVPEQTWSNHIRIFSQEGLEVIRYPYYSKEQKQLLFEPL
IAFLKEVEKNSVILLHGCCHNPTGVDFTEDMWKELAILMKERELIPFFDTAYQGFAHGIELDRKPIEIFISEGNTVLVAA
SSSKNFALYGERVGYFAVHSTFTDELVKIHSFLEEKIRGEYSSPQRWGVEIVSTILSNPYLKEEWQSELNFIRESLGKMR
TRFVQALRKVAGHTFDFLLSQHGFFAYPGFSDKQVLFLREQHAVYTTAGGRMNLNGITEKNIDHVVQSFIQAYEL
>Mature_394_residues
SFFNHIPTFSPDAILGLQNVFFADKRPEKVNLVIGVYEHPQKRYGGLSCIRKAQTVILEEEQNKSYLPISGLQIFLDEMR
ELVFGAVDPSAIVGFQSLGGTGALHLGARLLSVAKGSGKVYVPEQTWSNHIRIFSQEGLEVIRYPYYSKEQKQLLFEPLI
AFLKEVEKNSVILLHGCCHNPTGVDFTEDMWKELAILMKERELIPFFDTAYQGFAHGIELDRKPIEIFISEGNTVLVAAS
SSKNFALYGERVGYFAVHSTFTDELVKIHSFLEEKIRGEYSSPQRWGVEIVSTILSNPYLKEEWQSELNFIRESLGKMRT
RFVQALRKVAGHTFDFLLSQHGFFAYPGFSDKQVLFLREQHAVYTTAGGRMNLNGITEKNIDHVVQSFIQAYEL

Specific function: Unknown

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504067, Length=405, Percent_Identity=36.7901234567901, Blast_Score=248, Evalue=5e-66,
Organism=Homo sapiens, GI73486658, Length=396, Percent_Identity=35.1010101010101, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI117414139, Length=342, Percent_Identity=27.4853801169591, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1787159, Length=393, Percent_Identity=39.1857506361323, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI1790488, Length=393, Percent_Identity=37.6590330788804, Blast_Score=273, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=35.8585858585859, Blast_Score=263, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI25147133, Length=396, Percent_Identity=34.3434343434343, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17569539, Length=397, Percent_Identity=33.2493702770781, Blast_Score=231, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=35.8490566037736, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17569537, Length=396, Percent_Identity=26.7676767676768, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17550384, Length=251, Percent_Identity=32.6693227091633, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323055, Length=403, Percent_Identity=32.7543424317618, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6322743, Length=428, Percent_Identity=32.0093457943925, Blast_Score=209, Evalue=5e-55,
Organism=Drosophila melanogaster, GI24580972, Length=395, Percent_Identity=35.9493670886076, Blast_Score=266, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24580970, Length=395, Percent_Identity=35.9493670886076, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI19920542, Length=385, Percent_Identity=36.6233766233766, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI19922362, Length=397, Percent_Identity=34.5088161209068, Blast_Score=257, Evalue=1e-68,
Organism=Drosophila melanogaster, GI24654046, Length=397, Percent_Identity=34.5088161209068, Blast_Score=257, Evalue=1e-68,

Paralogues:

None

Copy number: 6,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 44938; Mature: 44807

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFNHIPTFSPDAILGLQNVFFADKRPEKVNLVIGVYEHPQKRYGGLSCIRKAQTVILE
CCHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHCHHHHHHHHHHEEEE
EEQNKSYLPISGLQIFLDEMRELVFGAVDPSAIVGFQSLGGTGALHLGARLLSVAKGSGK
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCE
VYVPEQTWSNHIRIFSQEGLEVIRYPYYSKEQKQLLFEPLIAFLKEVEKNSVILLHGCCH
EEECCCCCCCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
NPTGVDFTEDMWKELAILMKERELIPFFDTAYQGFAHGIELDRKPIEIFISEGNTVLVAA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEE
SSSKNFALYGERVGYFAVHSTFTDELVKIHSFLEEKIRGEYSSPQRWGVEIVSTILSNPY
CCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
LKEEWQSELNFIRESLGKMRTRFVQALRKVAGHTFDFLLSQHGFFAYPGFSDKQVLFLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCEEEEEEE
QHAVYTTAGGRMNLNGITEKNIDHVVQSFIQAYEL
CCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFFNHIPTFSPDAILGLQNVFFADKRPEKVNLVIGVYEHPQKRYGGLSCIRKAQTVILE
CHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHCHHHHHHHHHHEEEE
EEQNKSYLPISGLQIFLDEMRELVFGAVDPSAIVGFQSLGGTGALHLGARLLSVAKGSGK
ECCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCE
VYVPEQTWSNHIRIFSQEGLEVIRYPYYSKEQKQLLFEPLIAFLKEVEKNSVILLHGCCH
EEECCCCCCCCEEEEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCC
NPTGVDFTEDMWKELAILMKERELIPFFDTAYQGFAHGIELDRKPIEIFISEGNTVLVAA
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEEEE
SSSKNFALYGERVGYFAVHSTFTDELVKIHSFLEEKIRGEYSSPQRWGVEIVSTILSNPY
CCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
LKEEWQSELNFIRESLGKMRTRFVQALRKVAGHTFDFLLSQHGFFAYPGFSDKQVLFLRE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEECCCCCCCEEEEEEE
QHAVYTTAGGRMNLNGITEKNIDHVVQSFIQAYEL
CCEEEEECCCEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6378205; 3897210; 3521591; 3298240; 8905232; 9278503; 9298646; 1868057; 2007566; 2513875; 1993208; 9891001 [H]