Click here to switch to the map view.

The map label for this gene is msrA

Identifier: 13357849

GI number: 13357849

Start: 325542

End: 326039

Strand: Direct

Name: msrA

Synonym: UU289

Alternate gene names: 13357849

Gene position: 325542-326039 (Clockwise)

Preceding gene: 13357848

Following gene: 13357852

Centisome position: 43.31

GC content: 26.51

Gene sequence:

>498_bases
ATGATTAAGAGTATTTGAATTGCTGGAGGTTGTTTTTGAGGTATTCAAAAATATTTTGATAGCATTATTGGTGTTAATCA
TACAGTTGTTGGTTATAGTCAAGGAAACGTTATTAATCCAAGTTATGAACAAGTTTGCACTCAAACAACCAACCATACAG
AAACTGTTCAAATCGATTATGATGATCGTTTTGTTAGTTTAATAAGTATTTTAGAACATCTTTATCAAATCATTGATCCT
TTTAGTTTAAATAAGCAAGGCGATGATGTTGGTAGTCAATACCGTAGTGGTATTTATTATGTGGATCACGATGATGAGTT
TATTATTAAAGATTTTTTATTAAAAAAACAAAATCAAACACCAAAAAAAATTATGATTGAAGTTGAAAGATTACGCAATT
TTAATATTGCTGAAGAATACCATCAAAAATATTTAGATAAAAATCCTAATAGTTATTGTCATGTTGATTTATCATTATCT
AAAAAAGAATTCAGATAA

Upstream 100 bases:

>100_bases
GATTATGGTTTAGATAAACGTGATCAATGAATTAAAAAAATTATTCCTTTTGAAGAATAATTATAGTAAAATAAGAAAGT
CAATAGAGAGAGATAAATTT

Downstream 100 bases:

>100_bases
AAACCAGGCGTTTTTGCGTCTGGTTTTTATATTTTTTAATCATTAATATTATTACAAGATTGATATTTCTCTAATTTTTT
AATAACATTATCTTTTAAAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MIKSIWIAGGCFWGIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDDRFVSLISILEHLYQIIDP
FSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPKKIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLS
KKEFR

Sequences:

>Translated_165_residues
MIKSI*IAGGCF*GIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDDRFVSLISILEHLYQIIDP
FSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPKKIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLS
KKEFR
>Mature_165_residues
MIKSI*IAGGCF*GIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDDRFVSLISILEHLYQIIDP
FSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPKKIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLS
KKEFR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=33.974358974359, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=33.974358974359, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI208609993, Length=137, Percent_Identity=30.6569343065693, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1790665, Length=150, Percent_Identity=35.3333333333333, Blast_Score=96, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=35.625, Blast_Score=89, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=31.9148936170213, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=31.9148936170213, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18933; Mature: 18933

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSIIAGGCFGIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDD
CCCHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHCCCCCCEEEEEECCH
RFVSLISILEHLYQIIDPFSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCHH
KIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLSKKEFR
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC
>Mature Secondary Structure
MIKSIIAGGCFGIQKYFDSIIGVNHTVVGYSQGNVINPSYEQVCTQTTNHTETVQIDYDD
CCCHHHHCHHHHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHHCCCCCCEEEEEECCH
RFVSLISILEHLYQIIDPFSLNKQGDDVGSQYRSGIYYVDHDDEFIIKDFLLKKQNQTPK
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCHH
KIMIEVERLRNFNIAEEYHQKYLDKNPNSYCHVDLSLSKKEFR
HHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA