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The map label for this gene is tmk

Identifier: 13357576

GI number: 13357576

Start: 20468

End: 21169

Strand: Reverse

Name: tmk

Synonym: UU020

Alternate gene names: 13357576

Gene position: 21169-20468 (Counterclockwise)

Preceding gene: 13357577

Following gene: 13357575

Centisome position: 2.82

GC content: 24.07

Gene sequence:

>702_bases
ATGATAACAATGATATTAACGAAAAATAGTAATGAAAAAAAACCGCTTAAAAAAGGATTATTTATTGTTTTTGAAGGAAT
TGATGGTGCAGGGAAAACTTCAATCTTAAAACAACTTTTAGAGGTTTTAAAAGAACCTAAACTAGTTAATAAAATTTTTT
TAACGCGTGAACCTGGTGGAAAAAACAATAATGCAGCAGAGATGATACGTGAGTTTTTTTTAAAAAATTTAGAAGTTTTT
GATCCGTTAACACTAGCTTATTTATATGCAAGCAGTCGTGCTGAACACGTAAAAAAAACAATCAATCCTCATTTAGAAAA
AGATCATATTGTAATTTCAGATCGTTTTGTTCATTCTTCATATATTTATCAAGGTATTGTTCAAAATCAAAGTTTAGATG
TTATTTACCAAATTAATCAACAAGCAATTGGTGAATTAGAAATAGATTATGTTTTTTATTTTGATGTTAATGTTAATAAT
GCATTAAATCGAATGAAAAATCGTTTTGACAATACAAATGCATTCGATTCACAAAATAAACAATTTTATGAAAAGTTATT
AAAACAATACCCTAGTGTTTTTAAAGTTTATAATCAACCTAAAAAAATTATTTTTATTGATGCCAATAAAAATGAAAATG
AAGTATTATGTGAGGTTAAAGAACAATTATTAAAAATTTTTAAAGAACATAAATATATATAA

Upstream 100 bases:

>100_bases
TTTAATAATTCTGGTCATATTCCTTTTATTGAAGAACCAAAATTATTTACTAATATATTACTAAGTTTTTTAGAGGATAG
ATTTGTAGAACAAGAGGAAA

Downstream 100 bases:

>100_bases
ATGAAATACAGTTTTGCTAATTTATTAATTCAATCACCTAAAACCTCACTAGAATCAGGTATTGAAGAAATTATGTTAGC
TTTTATTTATGAGAAAAATC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MITMILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVF
DPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNN
ALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI

Sequences:

>Translated_233_residues
MITMILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVF
DPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNN
ALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
>Mature_233_residues
MITMILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGGKNNNAAEMIREFFLKNLEVF
DPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSSYIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNN
ALNRMKNRFDNTNAFDSQNKQFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=213, Percent_Identity=26.2910798122066, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 27246; Mature: 27246

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITMILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGG
CEEEEEECCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCC
KNNNAAEMIREFFLKNLEVFDPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSS
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
YIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNK
HHHHHHHCCCCCEEEEEECHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCH
QFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MITMILTKNSNEKKPLKKGLFIVFEGIDGAGKTSILKQLLEVLKEPKLVNKIFLTREPGG
CEEEEEECCCCCCCHHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCHHHHHEEEEECCCC
KNNNAAEMIREFFLKNLEVFDPLTLAYLYASSRAEHVKKTINPHLEKDHIVISDRFVHSS
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHH
YIYQGIVQNQSLDVIYQINQQAIGELEIDYVFYFDVNVNNALNRMKNRFDNTNAFDSQNK
HHHHHHHCCCCCEEEEEECHHHCCCEEEEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCH
QFYEKLLKQYPSVFKVYNQPKKIIFIDANKNENEVLCEVKEQLLKIFKEHKYI
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA