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Identifier: 15004733

GI number: 15004733

Start: 30112

End: 31311

Strand: Direct

Name: Not Available

Synonym: CA_P0029

Alternate gene names: 15004733

Gene position: 30112-31311 (Clockwise)

Preceding gene: 15004731

Following gene: 15004734

Centisome position: 15.68

GC content: 34.5

Gene sequence:

>1200_bases
ATGAAAATGTGGAAAAAAAATTTGATAGTTTGTTGGTTTGGAATGTTTATAACCAGTATAGGAATGAGTCAAATTGCCCC
AGTACTACCTCTTTACATAAGACATCTTGGGGTTAATAGCTCATCCTTAGTTGAAGAGTTTTCAGGTATTGCTTTTGGGA
TTACCTTTATAGTATCAGCTATTTTTTCTCCTATTTGGGGGCAAGCTGCTGATAAATTTGGTAGGAAGCCTATGCTTCTT
AGAGCAAGTTTTGGTATGGGAATAATTATATTTAGTATGGGTTTTGTATCAAATGTATATGTGCTTATAGTATTGAGATT
GCTTCAGGGTGTTATAACTGGTTACAGCACAGCTTGCACTACGCTAATTGCAACACAAACGGATAAAGAACATGCTGGAT
GGGCACTCGGCACACTTTCAACTGCTGGTATTGCAGGATCACTTCTTGGACCAACTATTGGTGGTTTTGTAGAAGAAGCC
TTTGGTACACAAAATGTATTTTTCATAACAGGTGCACTGCTTATAATTGTATTTATTGCTACAATGCTGTTTGTGAAGGA
AGATTTTGTACGTGAAAATAAAAAGGTTGATAGTATGAAGAAAGTATGGAATAGCGTTCCTGAAAAAAGTCTTACTATAA
CTATTCTTGTAACGTTTTTTATATTAACCTTAGCATTATACTCAATAGAACCAATTATGACAGAGTATGTTTCTAAGCTA
TCAAGGAATACTAGTCATGTTGCTTTTATAGCAGGGTTGGTTTTTTCAGCTTCGGGACTTGCTAACATAGTTGCAGCACC
AAGGCTTGGAAAAATTTCTGATAAAATTGGACCTCATAAGATTATGCTTGGTGCCCTCATAGTTGCAGGTATAGTATTTA
TACCGCAAGCTTTTGTTAAAAATCCATGGCAGTTAATGTTTTTTAGATTTTTATTAGGACTTGCATCAGGAGGATTAACT
CCATCAGTTAATATATTAGTAAAGAAAATCACACCTACGGCTATTACAGGAAGAATTTTTGGACTTAGTATGTCAGCAGG
ATACCTTGGTGTATTTGGAGGTTCAGTTTTAGGAGGGCAGGTTTCAGCTTATTTAGGAATTAGATATGTATTTTTTATTA
CCAGTTCACTGCTGCTTATAAATGCAGTGTGGGTTTATTTTAAAGTGTATAAAAAACTTAATTTAAAAGAAATAGTTTAA

Upstream 100 bases:

>100_bases
ATCTTAACATGTTAAGAGTTTTTTTACAAACTATATTTTATAGTTTACAAACTACATTGTATAGTTTATACTATAGCTTA
TAGAAAGAAGGACTGAATTT

Downstream 100 bases:

>100_bases
TATAAAGGAGATAACAATATGGAAAATTTAGAAATAGAAAAAACGGCCCTTGTGGTTATAGATTTGCAAAAAGGCATTGT
AGCTGGAGAGCATGCGCCTT

Product: permease MDR-related

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKMWKKNLIVCWFGMFITSIGMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSAIFSPIWGQAADKFGRKPMLL
RASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGYSTACTTLIATQTDKEHAGWALGTLSTAGIAGSLLGPTIGGFVEEA
FGTQNVFFITGALLIIVFIATMLFVKEDFVRENKKVDSMKKVWNSVPEKSLTITILVTFFILTLALYSIEPIMTEYVSKL
SRNTSHVAFIAGLVFSASGLANIVAAPRLGKISDKIGPHKIMLGALIVAGIVFIPQAFVKNPWQLMFFRFLLGLASGGLT
PSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQVSAYLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKEIV

Sequences:

>Translated_399_residues
MKMWKKNLIVCWFGMFITSIGMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSAIFSPIWGQAADKFGRKPMLL
RASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGYSTACTTLIATQTDKEHAGWALGTLSTAGIAGSLLGPTIGGFVEEA
FGTQNVFFITGALLIIVFIATMLFVKEDFVRENKKVDSMKKVWNSVPEKSLTITILVTFFILTLALYSIEPIMTEYVSKL
SRNTSHVAFIAGLVFSASGLANIVAAPRLGKISDKIGPHKIMLGALIVAGIVFIPQAFVKNPWQLMFFRFLLGLASGGLT
PSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQVSAYLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKEIV
>Mature_399_residues
MKMWKKNLIVCWFGMFITSIGMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSAIFSPIWGQAADKFGRKPMLL
RASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGYSTACTTLIATQTDKEHAGWALGTLSTAGIAGSLLGPTIGGFVEEA
FGTQNVFFITGALLIIVFIATMLFVKEDFVRENKKVDSMKKVWNSVPEKSLTITILVTFFILTLALYSIEPIMTEYVSKL
SRNTSHVAFIAGLVFSASGLANIVAAPRLGKISDKIGPHKIMLGALIVAGIVFIPQAFVKNPWQLMFFRFLLGLASGGLT
PSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQVSAYLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKEIV

Specific function: Confers resistance to fosfomycin and deoxycholate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtG (TC 2.A.1.2.20) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787291, Length=390, Percent_Identity=43.3333333333333, Blast_Score=312, Evalue=2e-86,
Organism=Escherichia coli, GI87082404, Length=378, Percent_Identity=24.0740740740741, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43337; Mature: 43337

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMWKKNLIVCWFGMFITSIGMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSA
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IFSPIWGQAADKFGRKPMLLRASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGYSTACT
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
TLIATQTDKEHAGWALGTLSTAGIAGSLLGPTIGGFVEEAFGTQNVFFITGALLIIVFIA
HHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TMLFVKEDFVRENKKVDSMKKVWNSVPEKSLTITILVTFFILTLALYSIEPIMTEYVSKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNTSHVAFIAGLVFSASGLANIVAAPRLGKISDKIGPHKIMLGALIVAGIVFIPQAFVK
HCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
NPWQLMFFRFLLGLASGGLTPSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQ
CCHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCHHHHEEEEEEECCCCHHHCCCCHHHHH
VSAYLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
>Mature Secondary Structure
MKMWKKNLIVCWFGMFITSIGMSQIAPVLPLYIRHLGVNSSSLVEEFSGIAFGITFIVSA
CCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
IFSPIWGQAADKFGRKPMLLRASFGMGIIIFSMGFVSNVYVLIVLRLLQGVITGYSTACT
HHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHH
TLIATQTDKEHAGWALGTLSTAGIAGSLLGPTIGGFVEEAFGTQNVFFITGALLIIVFIA
HHHHCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
TMLFVKEDFVRENKKVDSMKKVWNSVPEKSLTITILVTFFILTLALYSIEPIMTEYVSKL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRNTSHVAFIAGLVFSASGLANIVAAPRLGKISDKIGPHKIMLGALIVAGIVFIPQAFVK
HCCCCHHHHHHHHHHHHCCHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
NPWQLMFFRFLLGLASGGLTPSVNILVKKITPTAITGRIFGLSMSAGYLGVFGGSVLGGQ
CCHHHHHHHHHHHHHCCCCCCCHHEEEEECCCCHHHHEEEEEEECCCCHHHCCCCHHHHH
VSAYLGIRYVFFITSSLLLINAVWVYFKVYKKLNLKEIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA