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The map label for this gene is coaBC

Identifier: 15595157

GI number: 15595157

Start: 858939

End: 860111

Strand: Reverse

Name: coaBC

Synonym: BB0812

Alternate gene names: 15595157

Gene position: 860111-858939 (Counterclockwise)

Preceding gene: 15595168

Following gene: 15595138

Centisome position: 94.44

GC content: 27.37

Gene sequence:

>1173_bases
ATGGATAAAAATAAACATATATTAATTGGTATATGTGGGGGCATAGCCTCTTACAAGTCAGTTTACATAGTTTCCAGTTT
AGTTAAATTAGGATACAAAGTTAAAGTTATAATGACACAAAATGCAACTAAATTTATTACTCCATTAACTTTAGAAACCA
TTTCTAAGAACAAAATAATTACTAATTTATGGGATTTAGACCACAATGAGGTGGAGCATATAAAAATTGCAAAATGGGCA
CACCTAATTCTTGTTATTCCTGCTACCTACAACACAATATCTAAAATTGCATCAGGAATTGCTGATGATGCATTAACTAC
AATAATATCTGCAAGCACGGCTCCTACTTATTTTGCAATAGCAATGAATAATATAATGTATTCAAACCCTATTTTAAAAG
AAAATATAAAAAAGCTTAAAACTTATAATTATAAATTCATTGAACCTGATAAAGGATTTTTAGCTTGCTCATCAAATGCT
TTAGGGCGCCTTAAAAATGAAGACAAAATTATAAAAATAATATTGAATGAATTTAATCAAAAAGACTACCTAAAAAATAA
AAAAATACTTATAACAGCATCCAGAACTGAAGAATTAATAGATCCAATTCGCTATTTCTCAAATACATCAACGGGAAAAA
TGGGGTTTTGCTTAGCACAAGAGGCTGTCAAACTAGGAGCTCAAGTTACAATTATTACAGGACCAACCAATGAAAATGAT
CCTGAAGGGGTCAACATTATAAAAATAAAAACTGCAATGGAAATGTACAAGGAAGCTCTCAAAATATATAATAAATTTGA
AATAATAATTGGAGCCGCAGCTGTTGCCGATTTTAAACCCAAACACATTTTCAATAGTAAAATTAAAAAAAATAAAATCA
ATAGATTATATATAAAATTAGTAAAAAATCCCGACATAATCCAACACATAGGACACAATAAGCTTAAAAACCAAATTGTT
ATTGGATTTTGCGCTGAGAATTCTAAAAATTTAATTCAAAAAGCTAAAGAAAAATTAAAAAAGAAAAACTTGGACTTTAT
CATTGCAAATGAACTTAAATATTTTGGTTCAAAATTAAACAAAGTTTATATAATAAATAAACAAAGCATAAAAGAACTGC
CAGAAATGGAAAAATCAGAAGTAGCTAAAGAAATTTTAAAAATTTTATACTAA

Upstream 100 bases:

>100_bases
ATAGCGTACAAAATCCCATTTCTCATTTAAAACAACCTTAACAAAAGGACATCAAAATTTATAAATTCAAATATAATGTA
TATTATATAATATATATTAT

Downstream 100 bases:

>100_bases
TATGCTTAATAGTTTATTAATAATCAATAATCTTTTAAAAGCATTTTAATATATTCGGAGTTCGTTTCACTTTTAATTTT
TTTAAGCTTATCAGAAAGCG

Product: pantothenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKIITNLWDLDHNEVEHIKIAKWA
HLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAIAMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNA
LGRLKNEDKIIKIILNEFNQKDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNEND
PEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKLVKNPDIIQHIGHNKLKNQIV
IGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLNKVYIINKQSIKELPEMEKSEVAKEILKILY

Sequences:

>Translated_390_residues
MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKIITNLWDLDHNEVEHIKIAKWA
HLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAIAMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNA
LGRLKNEDKIIKIILNEFNQKDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNEND
PEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKLVKNPDIIQHIGHNKLKNQIV
IGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLNKVYIINKQSIKELPEMEKSEVAKEILKILY
>Mature_390_residues
MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKIITNLWDLDHNEVEHIKIAKWA
HLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAIAMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNA
LGRLKNEDKIIKIILNEFNQKDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNEND
PEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKLVKNPDIIQHIGHNKLKNQIV
IGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLNKVYIINKQSIKELPEMEKSEVAKEILKILY

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family

Homologues:

Organism=Homo sapiens, GI71725351, Length=175, Percent_Identity=32, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI87082301, Length=390, Percent_Identity=36.1538461538462, Blast_Score=236, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=31.5217391304348, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=29.2929292929293, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24657262, Length=191, Percent_Identity=29.3193717277487, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COABC_BORBU (O51752)

Other databases:

- EMBL:   AE000783
- PIR:   C70201
- RefSeq:   NP_212946.1
- ProteinModelPortal:   O51752
- SMR:   O51752
- EnsemblBacteria:   EBBORT00000008784
- GeneID:   1195670
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0812
- NMPDR:   fig|224326.1.peg.1196
- TIGR:   BB_0812
- GeneTree:   EBGT00050000007429
- HOGENOM:   HBG523890
- OMA:   VTSGPTH
- PhylomeDB:   O51752
- ProtClustDB:   CLSK507856
- BioCyc:   BBUR224326:BB_0812-MONOMER
- BRENDA:   4.1.1.36
- BRENDA:   6.3.2.5
- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382
- Gene3D:   G3DSA:3.40.50.10300
- Gene3D:   G3DSA:3.40.50.1950
- TIGRFAMs:   TIGR00521

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein; SSF102645 DNA/pantothenate-metab_flavo_C; SSF52507 Flavoprotein

EC number: =4.1.1.36; =6.3.2.5

Molecular weight: Translated: 44145; Mature: 44145

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: ACT_SITE 156-156 BINDING 123-123 BINDING 277-277 BINDING 287-287 BINDING 338-338 BINDING 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKII
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHCCCHHHHHCCCCCEE
TNLWDLDHNEVEHIKIAKWAHLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAI
EHHHCCCCCCHHHEEHEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
AMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNALGRLKNEDKIIKIILNEFNQ
EECCHHCCCCHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCC
KDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNEND
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
PEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKL
CCCEEEEEEHHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEE
VKNPDIIQHIGHNKLKNQIVIGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLN
ECCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCC
KVYIINKQSIKELPEMEKSEVAKEILKILY
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure
MDKNKHILIGICGGIASYKSVYIVSSLVKLGYKVKVIMTQNATKFITPLTLETISKNKII
CCCCCEEEEEECCCHHHHHHHHHHHHHHHCCEEEEEEEECCCCHHCCCHHHHHCCCCCEE
TNLWDLDHNEVEHIKIAKWAHLILVIPATYNTISKIASGIADDALTTIISASTAPTYFAI
EHHHCCCCCCHHHEEHEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEE
AMNNIMYSNPILKENIKKLKTYNYKFIEPDKGFLACSSNALGRLKNEDKIIKIILNEFNQ
EECCHHCCCCHHHHHHHHHHHCCEEEECCCCCEEEECCCCCCCCCCCCHHHHHHHHHCCC
KDYLKNKKILITASRTEELIDPIRYFSNTSTGKMGFCLAQEAVKLGAQVTIITGPTNEND
HHHHCCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
PEGVNIIKIKTAMEMYKEALKIYNKFEIIIGAAAVADFKPKHIFNSKIKKNKINRLYIKL
CCCEEEEEEHHHHHHHHHHHHHHHHHHEEEEEHHHHCCCCHHHHHHHHHHCCCCEEEEEE
VKNPDIIQHIGHNKLKNQIVIGFCAENSKNLIQKAKEKLKKKNLDFIIANELKYFGSKLN
ECCCHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCC
KVYIINKQSIKELPEMEKSEVAKEILKILY
EEEEEEHHHHHHCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685