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The map label for this gene is pncB [H]

Identifier: 15594980

GI number: 15594980

Start: 671767

End: 673212

Strand: Reverse

Name: pncB [H]

Synonym: BB0635

Alternate gene names: 15594980

Gene position: 673212-671767 (Counterclockwise)

Preceding gene: 15594984

Following gene: 15594979

Centisome position: 73.92

GC content: 28.84

Gene sequence:

>1446_bases
ATGAAAAATCTATCACTATTTACAGATTTTTATGAAATTTCAATGATGAACGCTTATTTTACAAAAGGAATTAATCCTAA
AGCAAAATTTGAAGTGTTTTTTAGAAAAACACCCTTTAAAAATGGCTATATTGTTTTAGCTGGAATGCATACATTGATTA
ATGAATTAAAAAATATTCGTTTTGGAGAAAATGAACTTAAATATTTAAAAAGCTTTAATATATTAGATAAACAATTTTTA
AACTTTCTAAGAGAATTCAAACTAAACGTAAAAATAAGCTCAATAGAAGAGGGTCGAATAGTTTTCCCCCAAGCACCAGT
AGTTGTGATTGAAGGACACTTAATAGAATTATTATTAATAGAAGGGTTAGTGTTAAATATAATAAACTTCGAAAGTTTGA
TAGCAACAAAAACCGCTAGAATAAAAGAATCTGGTGCAAAAATTTTAGCAGAACTTGGGCTAAGAAGAGCTCAAGGAATA
AATGGAGCACTTTCTGCCAGCAAAGCCGCCTACATAGGGGGAGCAGATTTCACAAGCAATATGCTTGCTGGATATAAATA
CAATATACCAGTTACAGGAACAATGGCTCATAGTTGGATAATGAGCTTTGAAACCGAAGAGCAAGCATTCAGAGAATATG
CAAAAACATATCCAAACAAAGTAAGTTTGCTAATCGATACTTACGACACGCTTAACAGTGGATTAAAAAATGCCATTAAA
ATATTCAAAGAATTAAAACATGAAGAAAAAAATAATTTTTCAATAAGAATTGACAGTGGAGATCTTGAATATTTAAGTAA
AGCAGCAAGAAAAGAATTAAACCGAAATGGATTAAATCATGTAAAAATTATTGCATCTAATGAGCTTGACGAAAATATTA
TCATGTACTTAAATTCAATAAATGCTCCAATTGATATTTGGGGCGTTGGAACAAATTTAGTTACAGCAAAAGGAGATCCA
AGCCTTTCAGGAGTATATAAAATGATCTCTATAGAAAAAAATGGAAAATTTATACCAAAAATAAAAATATCAAATAACGC
AGAAAAATCCACATTACCTGACCAAAAAGAAGTTGCAAGAATCTATTTAAATGACCAAATGATCCTTGATTTTATATTTT
TAAAAGAAGAAAAAGATAAAATCAAAGATCATCTGAATTCAAGAAAAGAATTTACCGTTTTTCATCCAATACAAGATAAC
ATTTTCAAAATCATCAAACAATATGACGATTTTGAATTTCTAACGCACACTGTCTTAGAAAATGGAAAACTTCGCAAAGG
CTACGAGTCTAGCTTAACCAATATTAGAAATAAAACCAAACTCGACTTAAGCAAACTTGAACATACGTACAAAAGAATAA
TTAATCCCCACATATATAAAGTAAGTATCAGTAAAAACTTAAGAAAGTTAAAAAACAAACTCACAAAAGATATCAAAAAC
AATTAA

Upstream 100 bases:

>100_bases
ATATATCACAAAAAACATATTCATAAAGATTAGCAGACAAAAATTAAGCTCAAATTAAATATCATTTTTTTATAAACAAA
ACTAGTATATAATAAGGAGA

Downstream 100 bases:

>100_bases
TATATGTATATATATAAAACTAACAAAGTAAATAAAATTTATAATAAAATTAAAGAACTAACTCAAAAAGACAATATTTT
TAAAAAAGAAACACTCATCA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIRFGENELKYLKSFNILDKQFL
NFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLIEGLVLNIINFESLIATKTARIKESGAKILAELGLRRAQGI
NGALSASKAAYIGGADFTSNMLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLIDTYDTLNSGLKNAIK
IFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSINAPIDIWGVGTNLVTAKGDP
SLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVARIYLNDQMILDFIFLKEEKDKIKDHLNSRKEFTVFHPIQDN
IFKIIKQYDDFEFLTHTVLENGKLRKGYESSLTNIRNKTKLDLSKLEHTYKRIINPHIYKVSISKNLRKLKNKLTKDIKN
N

Sequences:

>Translated_481_residues
MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIRFGENELKYLKSFNILDKQFL
NFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLIEGLVLNIINFESLIATKTARIKESGAKILAELGLRRAQGI
NGALSASKAAYIGGADFTSNMLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLIDTYDTLNSGLKNAIK
IFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSINAPIDIWGVGTNLVTAKGDP
SLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVARIYLNDQMILDFIFLKEEKDKIKDHLNSRKEFTVFHPIQDN
IFKIIKQYDDFEFLTHTVLENGKLRKGYESSLTNIRNKTKLDLSKLEHTYKRIINPHIYKVSISKNLRKLKNKLTKDIKN
N
>Mature_481_residues
MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIRFGENELKYLKSFNILDKQFL
NFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLIEGLVLNIINFESLIATKTARIKESGAKILAELGLRRAQGI
NGALSASKAAYIGGADFTSNMLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLIDTYDTLNSGLKNAIK
IFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSINAPIDIWGVGTNLVTAKGDP
SLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVARIYLNDQMILDFIFLKEEKDKIKDHLNSRKEFTVFHPIQDN
IFKIIKQYDDFEFLTHTVLENGKLRKGYESSLTNIRNKTKLDLSKLEHTYKRIINPHIYKVSISKNLRKLKNKLTKDIKN
N

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=530, Percent_Identity=29.4339622641509, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71997952, Length=541, Percent_Identity=34.1959334565619, Blast_Score=267, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI71997947, Length=541, Percent_Identity=34.1959334565619, Blast_Score=267, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI71997955, Length=211, Percent_Identity=45.0236966824645, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24581587, Length=522, Percent_Identity=33.1417624521073, Blast_Score=251, Evalue=7e-67,
Organism=Drosophila melanogaster, GI161076680, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24581595, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI28574709, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24581593, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=7e-35,
Organism=Drosophila melanogaster, GI24581591, Length=206, Percent_Identity=39.8058252427184, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 55146; Mature: 55146

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHHHHCCC
FGENELKYLKSFNILDKQFLNFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLI
CCCHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEECCCEEECCCCCEEEECCHHHHHHHH
EGLVLNIINFESLIATKTARIKESGAKILAELGLRRAQGINGALSASKAAYIGGADFTSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHH
MLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLIDTYDTLNSGLKNAIK
HHCCEEECCCEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHH
IFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSI
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECC
NAPIDIWGVGTNLVTAKGDPSLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVAR
CCCEEEEECCCEEEEECCCCCHHHHEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHHHE
IYLNDQMILDFIFLKEEKDKIKDHLNSRKEFTVFHPIQDNIFKIIKQYDDFEFLTHTVLE
EEECCCEEEHHHHHHCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHC
NGKLRKGYESSLTNIRNKTKLDLSKLEHTYKRIINPHIYKVSISKNLRKLKNKLTKDIKN
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCC
N
C
>Mature Secondary Structure
MKNLSLFTDFYEISMMNAYFTKGINPKAKFEVFFRKTPFKNGYIVLAGMHTLINELKNIR
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEEEEEHHHHHHHHHCCC
FGENELKYLKSFNILDKQFLNFLREFKLNVKISSIEEGRIVFPQAPVVVIEGHLIELLLI
CCCHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEEECCCEEECCCCCEEEECCHHHHHHHH
EGLVLNIINFESLIATKTARIKESGAKILAELGLRRAQGINGALSASKAAYIGGADFTSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHH
MLAGYKYNIPVTGTMAHSWIMSFETEEQAFREYAKTYPNKVSLLIDTYDTLNSGLKNAIK
HHCCEEECCCEECHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECHHHHHHHHHHHHH
IFKELKHEEKNNFSIRIDSGDLEYLSKAARKELNRNGLNHVKIIASNELDENIIMYLNSI
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECC
NAPIDIWGVGTNLVTAKGDPSLSGVYKMISIEKNGKFIPKIKISNNAEKSTLPDQKEVAR
CCCEEEEECCCEEEEECCCCCHHHHEEEEEEECCCCEEEEEEECCCCCCCCCCCHHHHHE
IYLNDQMILDFIFLKEEKDKIKDHLNSRKEFTVFHPIQDNIFKIIKQYDDFEFLTHTVLE
EEECCCEEEHHHHHHCHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHHHC
NGKLRKGYESSLTNIRNKTKLDLSKLEHTYKRIINPHIYKVSISKNLRKLKNKLTKDIKN
CCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]