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The map label for this gene is lon1

Identifier: 15594598

GI number: 15594598

Start: 261292

End: 263712

Strand: Reverse

Name: lon1

Synonym: BB0253

Alternate gene names: 15594598

Gene position: 263712-261292 (Counterclockwise)

Preceding gene: 15594602

Following gene: 15594591

Centisome position: 28.96

GC content: 32.01

Gene sequence:

>2421_bases
ATGGATGAATCTAAAAAAGCTAGGTCAGGAGATAAAAAAAAAGAAAAAGCCGTAGCTGGGATTTTACCCCATTCTAATAA
GCCCGCAAGAGTGCCTTTAATAGCGGTTCCTTCTCATCCAGTTTTTCCAGGGATGTTTATTCCGATTGTTTTAATCTCTG
ATTCTGATATGAAAGCAATCGATTATGCTATGAAAGGCAATGGGATCATTGCCTTATTTGTTTTGAATGATAAATTTTTA
GAAAAAAATAACAATAATGCTCAACAGAAATTAATTATTGATTATAGTAAAGATATTTATTCTGTTGGAGTTACTGGAAA
GATAATAAAAAAAATTAATCTTCCAGATGGTGGTTACAATATATTTGTTTCAACTTTTGATAGGATTAAATTTGTTAAAG
TTGTTCTTAATGATAAGTTTCCCATAATTGAGATTGACTATTTAAAGCAAATTCCAGTTAGAAAAGATGATATTCAATCA
AAGGCAGTTTACGGTAGTATTTTGCTTAGAACTAAAGAAATATTTGCACATAGGAAAATGCCGGAAGTTCAATTAAATAT
GGTTAATATTGAAGATAAGGGAAAACTATGTGATATTGTGGCTAGCACTATTTCGTCTTCAAAAAATGATCATCAAATAG
TTCTTGAAACTTTGAATGTAAAAGATAGGCTTAAAAAAGTTTTAGAACTGATTTATGAAGAGCTTAATTTAATTGAAATT
CAAAATAAAATTGCCAAGGGCATTCAAGAGAGATTAGAGAAACAGCAAAAAGAGTTTTTTTTAAAAGAACAGCTTAAGGC
TATTAAAGCTGAACTTGGCATAGGAGATAAAAAAAGCAGCGATTTAGAAAAGCTTAAAACCAAGCTAAAGGCTTTAGAGT
TGAAGGGAGAGCCTTTAGAGGTAGTTGAAAAAGAGTTAGAAAAATTTTCACTTCTTGAAACAAGTTCGGCTGAATACATT
GTTGTTAGAAATTATCTTGAGCTTATTACTGAGCTTCCTTGGCGAGATTTTAAAATTAATTTTGATAAATTAGATTTGCA
AAAATCTAAAAAAATTTTAGATAAAACTCATTACGGAATGAACGAAGTTAAGGATAGAATTATTGAATATATTTCTGTTC
TTAAGTTAAGAAAGACTCAAAAGGGGGCTATTATTCTTTTGGTGGGACCTCCTGGCGTGGGAAAAACTTCTATTGGGGCA
GCTATTGCAAAGGTTTTGCGTACCAAGTTTTTTAGGTTTTCTGTTGGTGGAATGCGCGATGAGTCGGAGATTAAGGGACA
CAGAAGAACTTATGTTGGTGCTTTGCCTGGAAAAATTATTCAGGGCTTAAGAATTACCAAGACAAATTCTCCTGTTTTTT
TAATTGATGAGGTGGATAAGATTTCTGCTTCAAGCTATGGGGATCCTTTTTCGGTTCTTCTTGAGGTTTTAGATCCTGAA
CAGAATGTTAGGTTTAGAGATCATTATCTTGATCTTCCTTTTGATATTTCGAATGTATTTTTTATTTTAACTGCTAATTC
TGTTGAAACAATACCAAGACCTTTGTTAAATAGAATGGAGATTATTGAAATTTCTGGATATATTGATAACGAAAAAATAG
AGATTGCAAGAAAGTATTTAATTCCCAAAGTTTTAAGTGAAAACGGAGTTGATAAAGATTCTTTAAAATTTCAAAGTTCA
TCTCTTGTTCAAATTGCTCAAGAGTATGCAAGAGATAATGGAGTGAGAAATTTTGAAAAATATTTAAACAAAATTGTAAG
AAAGGTTGCTAGAAAGCTTATTGAGAATACTGAGGTTAAATCTTATCAAATTTCCAATGACAATTTAGAAGAATATGTTG
GTGTGCCTGTTTTTAGAAAAGAAAGCATGCCTAATGCTATGTATTCAGGGATGGTAATGGGCCTTGCTTGGACAAATTAT
GGAGGTTCAACTTTGATGATTGAGACTGTAAAGACGGAATCCAAGGTGGGTGGAATTAAATTAACAGGTAGACTTGGGGA
TGTTATGAAAGAATCTGCTAATATTGCCTATACTTATGTTAATAGCATTAAAGGAGATTTAAGTATTAGTAAATCTTTTT
TTGAAAAAAATATTATTCATTTACATATTCCAGAAGGAGCTACCCCAAAAGATGGGCCTTCTGCAGGAATTACAATAGCT
AGTGCTTTTATCTCTCTTGCTCTTAATAAGGTTGTTAGACCCCATTTGGCTATGACAGGAGAACTTTCTCTTACTGGGAA
TGTAATGATGATAGGGGGCCTTAAAGAAAAAATAATTGCAGCAAAGCGCAGTGGCGTGGAGCATATTATTGTTCCTAAGG
CAAATAGAGTGGATTTAGAAGAGATTCCTACTAACATTAAGAGCGGAATTAATTTTTATCTTGTAGATAATATGCGCGAG
GTCATTAAATTATTGTTTTAA

Upstream 100 bases:

>100_bases
AATTCTCATTTTATTATTTTATAATAAAAAAAATTATTATTAAATGAATTTCCATAAAATATTTGTTTTGTTATAATTAG
CTTAGGAGATTTCAAGTTTT

Downstream 100 bases:

>100_bases
TTTTTTAAAATTGTTGTTTGAGGCTAGCTTTACTCTAGGTTTAAATAAATAAATTAATAATGGAAGAAGAGTTAGTGATG
CAAGAGATGTCGTTAGCATT

Product: ATP-dependent protease LA

Products: NA

Alternate protein names: ATP-dependent protease La 1

Number of amino acids: Translated: 806; Mature: 806

Protein sequence:

>806_residues
MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAIDYAMKGNGIIALFVLNDKFL
EKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYNIFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQS
KAVYGSILLRTKEIFAHRKMPEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEI
QNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLEVVEKELEKFSLLETSSAEYI
VVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGMNEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGA
AIAKVLRTKFFRFSVGGMRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPE
QNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYLIPKVLSENGVDKDSLKFQSS
SLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVKSYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNY
GGSTLMIETVKTESKVGGIKLTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIA
SAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLEEIPTNIKSGINFYLVDNMRE
VIKLLF

Sequences:

>Translated_806_residues
MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAIDYAMKGNGIIALFVLNDKFL
EKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYNIFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQS
KAVYGSILLRTKEIFAHRKMPEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEI
QNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLEVVEKELEKFSLLETSSAEYI
VVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGMNEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGA
AIAKVLRTKFFRFSVGGMRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPE
QNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYLIPKVLSENGVDKDSLKFQSS
SLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVKSYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNY
GGSTLMIETVKTESKVGGIKLTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIA
SAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLEEIPTNIKSGINFYLVDNMRE
VIKLLF
>Mature_806_residues
MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAIDYAMKGNGIIALFVLNDKFL
EKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYNIFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQS
KAVYGSILLRTKEIFAHRKMPEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEI
QNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLEVVEKELEKFSLLETSSAEYI
VVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGMNEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGA
AIAKVLRTKFFRFSVGGMRDESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPE
QNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYLIPKVLSENGVDKDSLKFQSS
SLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVKSYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNY
GGSTLMIETVKTESKVGGIKLTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIA
SAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLEEIPTNIKSGINFYLVDNMRE
VIKLLF

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=620, Percent_Identity=46.2903225806452, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI31377667, Length=768, Percent_Identity=33.8541666666667, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1786643, Length=786, Percent_Identity=39.058524173028, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17505831, Length=704, Percent_Identity=41.0511363636364, Blast_Score=523, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17556486, Length=537, Percent_Identity=39.4785847299814, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6319449, Length=683, Percent_Identity=43.9238653001464, Blast_Score=578, Evalue=1e-166,
Organism=Drosophila melanogaster, GI221513036, Length=682, Percent_Identity=44.4281524926686, Blast_Score=560, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24666867, Length=682, Percent_Identity=44.4281524926686, Blast_Score=560, Evalue=1e-159,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON1_BORBU (Q59185)

Other databases:

- EMBL:   L77216
- EMBL:   AE000783
- PIR:   E70131
- RefSeq:   NP_212387.1
- ProteinModelPortal:   Q59185
- MEROPS:   S16.002
- EnsemblBacteria:   EBBORT00000008555
- GeneID:   1195090
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0253
- NMPDR:   fig|224326.1.peg.637
- TIGR:   BB_0253
- GeneTree:   EBGT00050000007303
- HOGENOM:   HBG566281
- OMA:   NIKNGIN
- PhylomeDB:   Q59185
- ProtClustDB:   CLSK544900
- BioCyc:   BBUR224326:BB_0253-MONOMER
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 90711; Mature: 90711

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 714-714 ACT_SITE 757-757

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAI
CCCCCCCCCCCHHHHHHHEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHH
DYAMKGNGIIALFVLNDKFLEKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYN
HHEECCCCEEEEEEECCHHHHCCCCCCCEEEEEEECCCEEEECCCCEEHEEECCCCCCCE
IFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQSKAVYGSILLRTKEIFAHRKM
EEEEHHHHHHEEEEEECCCCCEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEI
CCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
QNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
VVEKELEKFSLLETSSAEYIVVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGM
HHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCH
NEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGAAIAKVLRTKFFRFSVGGMRD
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCC
ESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPE
HHHHCCCHHEEEECCCHHHHCCEEEEECCCCEEEEECCCHHCCCCCCCHHHHHHHHHCCC
QNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYL
CCCEEEHEEECCCEECCCEEEEEECCCHHHCCHHHHCCEEEEEEECCCCCHHHHHHHHHH
IPKVLSENGVDKDSLKFQSSSLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVK
HHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNYGGSTLMIETVKTESKVGGIK
EEEECCCCHHHHHCCCEEECCCCCCHHHHCEEEEEEEECCCCCEEEEEEEECCCCCCCEE
LTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIA
EECHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHH
SAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLE
HHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCHHHHHHHHHCCCCEEEECCCCCCCHH
EIPTNIKSGINFYLVDNMREVIKLLF
HHCCHHHCCCEEEEHHHHHHHHHHHC
>Mature Secondary Structure
MDESKKARSGDKKKEKAVAGILPHSNKPARVPLIAVPSHPVFPGMFIPIVLISDSDMKAI
CCCCCCCCCCCHHHHHHHEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCHHH
DYAMKGNGIIALFVLNDKFLEKNNNNAQQKLIIDYSKDIYSVGVTGKIIKKINLPDGGYN
HHEECCCCEEEEEEECCHHHHCCCCCCCEEEEEEECCCEEEECCCCEEHEEECCCCCCCE
IFVSTFDRIKFVKVVLNDKFPIIEIDYLKQIPVRKDDIQSKAVYGSILLRTKEIFAHRKM
EEEEHHHHHHEEEEEECCCCCEEEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
PEVQLNMVNIEDKGKLCDIVASTISSSKNDHQIVLETLNVKDRLKKVLELIYEELNLIEI
CCEEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHH
QNKIAKGIQERLEKQQKEFFLKEQLKAIKAELGIGDKKSSDLEKLKTKLKALELKGEPLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
VVEKELEKFSLLETSSAEYIVVRNYLELITELPWRDFKINFDKLDLQKSKKILDKTHYGM
HHHHHHHHHHHEECCCCCEEEHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHCCCH
NEVKDRIIEYISVLKLRKTQKGAIILLVGPPGVGKTSIGAAIAKVLRTKFFRFSVGGMRD
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHEECCCCCC
ESEIKGHRRTYVGALPGKIIQGLRITKTNSPVFLIDEVDKISASSYGDPFSVLLEVLDPE
HHHHCCCHHEEEECCCHHHHCCEEEEECCCCEEEEECCCHHCCCCCCCHHHHHHHHHCCC
QNVRFRDHYLDLPFDISNVFFILTANSVETIPRPLLNRMEIIEISGYIDNEKIEIARKYL
CCCEEEHEEECCCEECCCEEEEEECCCHHHCCHHHHCCEEEEEEECCCCCHHHHHHHHHH
IPKVLSENGVDKDSLKFQSSSLVQIAQEYARDNGVRNFEKYLNKIVRKVARKLIENTEVK
HHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
SYQISNDNLEEYVGVPVFRKESMPNAMYSGMVMGLAWTNYGGSTLMIETVKTESKVGGIK
EEEECCCCHHHHHCCCEEECCCCCCHHHHCEEEEEEEECCCCCEEEEEEEECCCCCCCEE
LTGRLGDVMKESANIAYTYVNSIKGDLSISKSFFEKNIIHLHIPEGATPKDGPSAGITIA
EECHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHH
SAFISLALNKVVRPHLAMTGELSLTGNVMMIGGLKEKIIAAKRSGVEHIIVPKANRVDLE
HHHHHHHHHHHHCCCCEEEEEEEECCCEEEECCCHHHHHHHHHCCCCEEEECCCCCCCHH
EIPTNIKSGINFYLVDNMREVIKLLF
HHCCHHHCCCEEEEHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9266683; 9403685