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The map label for this gene is fadD [C]

Identifier: 15594482

GI number: 15594482

Start: 135874

End: 137766

Strand: Reverse

Name: fadD [C]

Synonym: BB0137

Alternate gene names: 15594482

Gene position: 137766-135874 (Counterclockwise)

Preceding gene: 15594483

Following gene: 15594480

Centisome position: 15.13

GC content: 30.85

Gene sequence:

>1893_bases
ATGTCAATAGCAAAGGCATTTTTTGAAGTGGCTGATCAACAAAAAGATAAAATTGCTCAAATGTATAAAGTTTGCAATGG
ATATGCCCACGTTACTTATGGCGACTTAAAAAACAATGTTTTAAAGCTTGCTTCCTTTTTAAAGTCAATCAATGTTAAGC
ATCAAGATAAAATATTTATTTGCTCTGAGAATAGGGCTGAGTGGACTGTGATAGATTTTGCAATTTTATCTTTGGGTGCC
GTTGATATTCCAAAGGGTTCTGATGTTACTCTTTTTGAAGCGGAAATTATTTTTAACTCCGTTCTTCCAAGTGTAGTTAT
TTTAGAAAATTTAAATCTTCTTAATATGTTTATTCAAATTAAATTTACAGTAAAGCCAATATTTATTATTATTGAAAATT
TAAACCAAGAGGATAGATTAAAATATAGTGATTTTGAAATTTATACTTATAGCGATTGTATTTTATTTGGAGATACCTTA
AGAAAAGATTCAGAAATTATTGAGATTGCAAGTAAAGTTGATTCTAATGATATGGCAACAATAATATATACTTCTGGAAC
AACAGGCCACCCAAAGGGGGTAATGCTCAGCCATGCCAATCTTCTTTATCAGGTTTCTAGTTTTAGTTTAATGGTTGATA
CGCATGTGGGACAAATATTTATGTGCATTTTGCCAATTTGGCATTCCTTTCAAAGGTCTTTTTCTTACAATATTTTCCTC
AAGGGTATGGTTTGTTTATTTTCCACCATTGTTCCAAGGGCAATGCTTGATGATATTAAAAATGTTAATCCTCATTATAT
TGCAGCTGTTCCTAGGCTTTGGATTGCAATAAGACAAAATATTTACAAAGAAGTTTCTAAGAAACCGTTTATTTCTAGAA
TGATTTTTCATTTTTTTGTAAAAGCGGCATTTCTTAGCGATATTTGCTATAGGGTGGTAATGGGGCTTTATCCGGACAAC
GGGTTTAGTTTATTTTTCCCTATAAAGAAAATTTTAGGAATATTTGGATTAATCTGTGCATTTCCTTTTAAGGCTTTGGG
GAATGTTTTAATTTTTAATAAAATAAATAAGATCTTGGGCAATAATTTTGTTGTTGGGATTACTGGTGGCGGGAGTATGC
CATTGTCTGCTGTTAGATTTTTTAATTCAATTGGTATTGAGCTTGCCAATGCTTATGGATTGACTGAAACCTCGCCTGGA
GTGGCTTCTAATAAGCATAAAAAAGTGATTATTGGGACTTGTGGTAAAATTTTGCCCGGAACTGTTGCTGAAATTAGAGA
TATTGATGGGAATAAGCTTAAAAAGCCTGGAAAGGGAATTTTGTTTGTAAAAGGGCCTCAAGTAATGCTTGGATATTACA
AGGACAAAGAAGCAACTTGTAAGATTATTGGTTCTGATGGGTTTTTAAACACGGGTGATATTGCAAAATTATCCAAGGAT
AATGTTGTTCAAATTATTGGTCGAGAAAAAGATACAATTGTTTTGAATAATGGAGAGAATGTTGAGCCTGCTCCAATTGA
GATTAAGCTTGAAGAATCAGCATTAATAGAAAAAGCAGTTGTTGTAGGGCAAGATCAAAAATTCTTAGGCGCTCTTATTC
TTCCAAATTTTGAAGAAATAAATAAATATCTAGAAAGTGTTGGACAAAAAATTTTTGATGCTAATAATAGGCGTCAAATT
ATTGCGAATAATATTGTTCTTAAGGCCATAAATGATGAAATAAAAAAATTAATCAATAAAGCCAATGGATTTAAGCCTTT
TGAGCAGATATTAAAGTTTACTCTTTTAGAAAAACCATTTGAAGTTGGTAAAGAAATGTCTATTAAAATGGACATTAAGC
GAAGCTATATTTTAAATTTTTATAAAAATGAAATTAAAAATTTATTTATTTAA

Upstream 100 bases:

>100_bases
GTATGTTTTTACAGCAGGAGAGCTTTATAAATAATCTTTATGAATTTATGGTTAATAATGATATAATAAACCATGTTAAC
TTTGTTAAAAGGGGGATTAT

Downstream 100 bases:

>100_bases
TTAACCCAATTATTTTAAATACAGTTCAAGCTCTGTTATATCTTCTAATTTTGTATTGGGGGATATACTTTGCTTGTAAA
CAAATCCATCGCCATTTATT

Product: long-chain-fatty-acid CoA ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MSIAKAFFEVADQQKDKIAQMYKVCNGYAHVTYGDLKNNVLKLASFLKSINVKHQDKIFICSENRAEWTVIDFAILSLGA
VDIPKGSDVTLFEAEIIFNSVLPSVVILENLNLLNMFIQIKFTVKPIFIIIENLNQEDRLKYSDFEIYTYSDCILFGDTL
RKDSEIIEIASKVDSNDMATIIYTSGTTGHPKGVMLSHANLLYQVSSFSLMVDTHVGQIFMCILPIWHSFQRSFSYNIFL
KGMVCLFSTIVPRAMLDDIKNVNPHYIAAVPRLWIAIRQNIYKEVSKKPFISRMIFHFFVKAAFLSDICYRVVMGLYPDN
GFSLFFPIKKILGIFGLICAFPFKALGNVLIFNKINKILGNNFVVGITGGGSMPLSAVRFFNSIGIELANAYGLTETSPG
VASNKHKKVIIGTCGKILPGTVAEIRDIDGNKLKKPGKGILFVKGPQVMLGYYKDKEATCKIIGSDGFLNTGDIAKLSKD
NVVQIIGREKDTIVLNNGENVEPAPIEIKLEESALIEKAVVVGQDQKFLGALILPNFEEINKYLESVGQKIFDANNRRQI
IANNIVLKAINDEIKKLINKANGFKPFEQILKFTLLEKPFEVGKEMSIKMDIKRSYILNFYKNEIKNLFI

Sequences:

>Translated_630_residues
MSIAKAFFEVADQQKDKIAQMYKVCNGYAHVTYGDLKNNVLKLASFLKSINVKHQDKIFICSENRAEWTVIDFAILSLGA
VDIPKGSDVTLFEAEIIFNSVLPSVVILENLNLLNMFIQIKFTVKPIFIIIENLNQEDRLKYSDFEIYTYSDCILFGDTL
RKDSEIIEIASKVDSNDMATIIYTSGTTGHPKGVMLSHANLLYQVSSFSLMVDTHVGQIFMCILPIWHSFQRSFSYNIFL
KGMVCLFSTIVPRAMLDDIKNVNPHYIAAVPRLWIAIRQNIYKEVSKKPFISRMIFHFFVKAAFLSDICYRVVMGLYPDN
GFSLFFPIKKILGIFGLICAFPFKALGNVLIFNKINKILGNNFVVGITGGGSMPLSAVRFFNSIGIELANAYGLTETSPG
VASNKHKKVIIGTCGKILPGTVAEIRDIDGNKLKKPGKGILFVKGPQVMLGYYKDKEATCKIIGSDGFLNTGDIAKLSKD
NVVQIIGREKDTIVLNNGENVEPAPIEIKLEESALIEKAVVVGQDQKFLGALILPNFEEINKYLESVGQKIFDANNRRQI
IANNIVLKAINDEIKKLINKANGFKPFEQILKFTLLEKPFEVGKEMSIKMDIKRSYILNFYKNEIKNLFI
>Mature_629_residues
SIAKAFFEVADQQKDKIAQMYKVCNGYAHVTYGDLKNNVLKLASFLKSINVKHQDKIFICSENRAEWTVIDFAILSLGAV
DIPKGSDVTLFEAEIIFNSVLPSVVILENLNLLNMFIQIKFTVKPIFIIIENLNQEDRLKYSDFEIYTYSDCILFGDTLR
KDSEIIEIASKVDSNDMATIIYTSGTTGHPKGVMLSHANLLYQVSSFSLMVDTHVGQIFMCILPIWHSFQRSFSYNIFLK
GMVCLFSTIVPRAMLDDIKNVNPHYIAAVPRLWIAIRQNIYKEVSKKPFISRMIFHFFVKAAFLSDICYRVVMGLYPDNG
FSLFFPIKKILGIFGLICAFPFKALGNVLIFNKINKILGNNFVVGITGGGSMPLSAVRFFNSIGIELANAYGLTETSPGV
ASNKHKKVIIGTCGKILPGTVAEIRDIDGNKLKKPGKGILFVKGPQVMLGYYKDKEATCKIIGSDGFLNTGDIAKLSKDN
VVQIIGREKDTIVLNNGENVEPAPIEIKLEESALIEKAVVVGQDQKFLGALILPNFEEINKYLESVGQKIFDANNRRQII
ANNIVLKAINDEIKKLINKANGFKPFEQILKFTLLEKPFEVGKEMSIKMDIKRSYILNFYKNEIKNLFI

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI40807491, Length=586, Percent_Identity=24.5733788395904, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI27477105, Length=660, Percent_Identity=22.8787878787879, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI42794760, Length=630, Percent_Identity=24.9206349206349, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI42794758, Length=630, Percent_Identity=24.9206349206349, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI42794756, Length=630, Percent_Identity=24.2857142857143, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI83745141, Length=595, Percent_Identity=24.3697478991597, Blast_Score=149, Evalue=8e-36,
Organism=Homo sapiens, GI57165410, Length=615, Percent_Identity=24.390243902439, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI57165412, Length=615, Percent_Identity=24.2276422764228, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI12669909, Length=641, Percent_Identity=24.1809672386895, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI4758332, Length=641, Percent_Identity=24.1809672386895, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI42794754, Length=487, Percent_Identity=22.9979466119097, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI42794752, Length=487, Percent_Identity=22.9979466119097, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI156151445, Length=176, Percent_Identity=30.6818181818182, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1788107, Length=204, Percent_Identity=34.8039215686275, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI145693145, Length=167, Percent_Identity=29.940119760479, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17541856, Length=595, Percent_Identity=25.0420168067227, Blast_Score=161, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17556552, Length=634, Percent_Identity=25.2365930599369, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17510401, Length=590, Percent_Identity=25.0847457627119, Blast_Score=146, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI25147511, Length=646, Percent_Identity=23.5294117647059, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI193204819, Length=529, Percent_Identity=26.0869565217391, Blast_Score=131, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17553312, Length=560, Percent_Identity=25, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17564090, Length=471, Percent_Identity=25.6900212314225, Blast_Score=119, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI17560308, Length=163, Percent_Identity=33.1288343558282, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=206, Percent_Identity=27.1844660194175, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI133901848, Length=197, Percent_Identity=25.3807106598985, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320852, Length=606, Percent_Identity=24.5874587458746, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6324893, Length=383, Percent_Identity=25.3263707571802, Blast_Score=121, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323903, Length=551, Percent_Identity=23.7749546279492, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6322182, Length=648, Percent_Identity=21.6049382716049, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281366413, Length=616, Percent_Identity=22.5649350649351, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24666501, Length=616, Percent_Identity=22.5649350649351, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24666497, Length=616, Percent_Identity=22.5649350649351, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI62471689, Length=653, Percent_Identity=24.5022970903522, Blast_Score=135, Evalue=9e-32,
Organism=Drosophila melanogaster, GI62471681, Length=653, Percent_Identity=24.5022970903522, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI62471687, Length=653, Percent_Identity=24.5022970903522, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24586634, Length=653, Percent_Identity=24.5022970903522, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI22026970, Length=653, Percent_Identity=24.5022970903522, Blast_Score=135, Evalue=1e-31,
Organism=Drosophila melanogaster, GI62471679, Length=653, Percent_Identity=24.5022970903522, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI62471683, Length=653, Percent_Identity=24.5022970903522, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI62471685, Length=653, Percent_Identity=24.5022970903522, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24586636, Length=653, Percent_Identity=24.5022970903522, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17933690, Length=642, Percent_Identity=23.6760124610592, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI19921316, Length=547, Percent_Identity=23.400365630713, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24581924, Length=161, Percent_Identity=32.2981366459627, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 70764; Mature: 70633

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAKAFFEVADQQKDKIAQMYKVCNGYAHVTYGDLKNNVLKLASFLKSINVKHQDKIFI
CCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCEEEE
CSENRAEWTVIDFAILSLGAVDIPKGSDVTLFEAEIIFNSVLPSVVILENLNLLNMFIQI
ECCCCCCEEEEHHHHHHCCCEECCCCCCEEEEEHHHHHHHHCCHHHHHHCCCEEEEEEEE
KFTVKPIFIIIENLNQEDRLKYSDFEIYTYSDCILFGDTLRKDSEIIEIASKVDSNDMAT
EEEECEEEEEEECCCHHHCCEECCEEEEEECCEEEECCHHCCCHHHHHHHHHCCCCCCEE
IIYTSGTTGHPKGVMLSHANLLYQVSSFSLMVDTHVGQIFMCILPIWHSFQRSFSYNIFL
EEEECCCCCCCCCEEEECCHHEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
KGMVCLFSTIVPRAMLDDIKNVNPHYIAAVPRLWIAIRQNIYKEVSKKPFISRMIFHFFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KAAFLSDICYRVVMGLYPDNGFSLFFPIKKILGIFGLICAFPFKALGNVLIFNKINKILG
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHC
NNFVVGITGGGSMPLSAVRFFNSIGIELANAYGLTETSPGVASNKHKKVIIGTCGKILPG
CCEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
TVAEIRDIDGNKLKKPGKGILFVKGPQVMLGYYKDKEATCKIIGSDGFLNTGDIAKLSKD
CHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
NVVQIIGREKDTIVLNNGENVEPAPIEIKLEESALIEKAVVVGQDQKFLGALILPNFEEI
CEEEEECCCCCEEEEECCCCCCCCCEEEEECHHHHHHHHHHCCCCCHHHHHEECCCHHHH
NKYLESVGQKIFDANNRRQIIANNIVLKAINDEIKKLINKANGFKPFEQILKFTLLEKPF
HHHHHHHHHHHHCCCCCCEEEECCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHH
EVGKEMSIKMDIKRSYILNFYKNEIKNLFI
HCCCCEEEEEEHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIAKAFFEVADQQKDKIAQMYKVCNGYAHVTYGDLKNNVLKLASFLKSINVKHQDKIFI
CHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHCCCCCCCEEEE
CSENRAEWTVIDFAILSLGAVDIPKGSDVTLFEAEIIFNSVLPSVVILENLNLLNMFIQI
ECCCCCCEEEEHHHHHHCCCEECCCCCCEEEEEHHHHHHHHCCHHHHHHCCCEEEEEEEE
KFTVKPIFIIIENLNQEDRLKYSDFEIYTYSDCILFGDTLRKDSEIIEIASKVDSNDMAT
EEEECEEEEEEECCCHHHCCEECCEEEEEECCEEEECCHHCCCHHHHHHHHHCCCCCCEE
IIYTSGTTGHPKGVMLSHANLLYQVSSFSLMVDTHVGQIFMCILPIWHSFQRSFSYNIFL
EEEECCCCCCCCCEEEECCHHEEEECCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCHHH
KGMVCLFSTIVPRAMLDDIKNVNPHYIAAVPRLWIAIRQNIYKEVSKKPFISRMIFHFFV
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
KAAFLSDICYRVVMGLYPDNGFSLFFPIKKILGIFGLICAFPFKALGNVLIFNKINKILG
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHC
NNFVVGITGGGSMPLSAVRFFNSIGIELANAYGLTETSPGVASNKHKKVIIGTCGKILPG
CCEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCC
TVAEIRDIDGNKLKKPGKGILFVKGPQVMLGYYKDKEATCKIIGSDGFLNTGDIAKLSKD
CHHHHHCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCC
NVVQIIGREKDTIVLNNGENVEPAPIEIKLEESALIEKAVVVGQDQKFLGALILPNFEEI
CEEEEECCCCCEEEEECCCCCCCCCEEEEECHHHHHHHHHHCCCCCHHHHHEECCCHHHH
NKYLESVGQKIFDANNRRQIIANNIVLKAINDEIKKLINKANGFKPFEQILKFTLLEKPF
HHHHHHHHHHHHCCCCCCEEEECCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCHH
EVGKEMSIKMDIKRSYILNFYKNEIKNLFI
HCCCCEEEEEEHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]