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The map label for this gene is tpiA [H]

Identifier: 15594401

GI number: 15594401

Start: 50490

End: 51251

Strand: Reverse

Name: tpiA [H]

Synonym: BB0055

Alternate gene names: 15594401

Gene position: 51251-50490 (Counterclockwise)

Preceding gene: 15594402

Following gene: 15594400

Centisome position: 5.63

GC content: 33.33

Gene sequence:

>762_bases
ATGAGAAAAACATTTTTAGCGGGAAATTGGAAAATGCATTATACAAGTGCAGAAGCTTCTATTGTTGCAAAAAAAATTGC
AACTGAGGTTAAGACCTTAAAAGATGATGTTGTAATAATGATAACTCCCCCATTTACGGCTTTATCTAAGGTTTCAGAAT
GTATTAAGGGTAGTAACATTCTCCTTGGTGCTCAAAATATGTCTTATATGGAAAGTGGAGCAAGGACAAGTGAAATTTCA
CCTTCAATGCTTTTAGAATTTGGAGTAGAATATGTTATACTTGGTCATTCTGAATGTAGGTTGTATTTAGCAGAAACAGA
TGAAATAATAAATAAAAAGATTCTTGCAGGACTTAAGCATCCTTTCAAATACTTAATTCTTTGTGTTGGAGAAACTCTTG
ATGAAAGAGATTCTGGAAAAACTTTAGAGGTTGTTTTAAATCAGGTTAAAAAGGGGTTAAATTGTGTTTCTGAATCAGAT
ATTCAAAGGATAATTTTAGCTTACGAACCTGTTTGGGCAATTGGAACGGGTAAAACCGCAACTAAAGAAGAGGCAGAAGA
GGTTCATAAGGCAATTAGGCTTGAGATTACGAAGCTTTATTCAAAGTCAGCTTCAGACAATATTATAATTCAGTATGGAG
GCTCTGTTAATTCAAACAATGTAAAAGAGCTTATGAATGAGCCTAATATTGATGGTGCGCTAATAGGTGGAGCATCTTTA
AAGGCCGAATCTTTTTTATCTATAATTAACAATGTTCTTTAG

Upstream 100 bases:

>100_bases
TTATCTGATAAGATTACTCATGTTTCAACGGGCGGTGGTGCATCGCTTGAATATCTTGAAGGGAGAATTTTGCCGGGTAT
TAAGGTTTTGGAGAATTAAA

Downstream 100 bases:

>100_bases
TTGAAGAGGTTTGTTTTGGATTTAGTTAGATTTTTTATTTTTATAATTTTTGTTATTGTTTCGATTTTTATTATCCTTTT
AGTTTTAATTCAAGATGAGC

Product: triosephosphate isomerase

Products: NA

Alternate protein names: TIM; Triose-phosphate isomerase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MRKTFLAGNWKMHYTSAEASIVAKKIATEVKTLKDDVVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEIS
PSMLLEFGVEYVILGHSECRLYLAETDEIINKKILAGLKHPFKYLILCVGETLDERDSGKTLEVVLNQVKKGLNCVSESD
IQRIILAYEPVWAIGTGKTATKEEAEEVHKAIRLEITKLYSKSASDNIIIQYGGSVNSNNVKELMNEPNIDGALIGGASL
KAESFLSIINNVL

Sequences:

>Translated_253_residues
MRKTFLAGNWKMHYTSAEASIVAKKIATEVKTLKDDVVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEIS
PSMLLEFGVEYVILGHSECRLYLAETDEIINKKILAGLKHPFKYLILCVGETLDERDSGKTLEVVLNQVKKGLNCVSESD
IQRIILAYEPVWAIGTGKTATKEEAEEVHKAIRLEITKLYSKSASDNIIIQYGGSVNSNNVKELMNEPNIDGALIGGASL
KAESFLSIINNVL
>Mature_253_residues
MRKTFLAGNWKMHYTSAEASIVAKKIATEVKTLKDDVVIMITPPFTALSKVSECIKGSNILLGAQNMSYMESGARTSEIS
PSMLLEFGVEYVILGHSECRLYLAETDEIINKKILAGLKHPFKYLILCVGETLDERDSGKTLEVVLNQVKKGLNCVSESD
IQRIILAYEPVWAIGTGKTATKEEAEEVHKAIRLEITKLYSKSASDNIIIQYGGSVNSNNVKELMNEPNIDGALIGGASL
KAESFLSIINNVL

Specific function: Plays an important role in several metabolic pathways. [C]

COG id: COG0149

COG function: function code G; Triosephosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the triosephosphate isomerase family [H]

Homologues:

Organism=Homo sapiens, GI226529917, Length=250, Percent_Identity=41.2, Blast_Score=175, Evalue=3e-44,
Organism=Homo sapiens, GI4507645, Length=250, Percent_Identity=41.2, Blast_Score=175, Evalue=4e-44,
Organism=Escherichia coli, GI1790353, Length=249, Percent_Identity=42.9718875502008, Blast_Score=195, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17536593, Length=253, Percent_Identity=41.897233201581, Blast_Score=183, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6320255, Length=253, Percent_Identity=40.3162055335968, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI28572008, Length=253, Percent_Identity=42.2924901185771, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28572006, Length=253, Percent_Identity=42.2924901185771, Blast_Score=179, Evalue=1e-45,
Organism=Drosophila melanogaster, GI28572004, Length=253, Percent_Identity=42.2924901185771, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: 1120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022896
- InterPro:   IPR000652
- InterPro:   IPR020861 [H]

Pfam domain/function: PF00121 TIM [H]

EC number: =5.3.1.1 [H]

Molecular weight: Translated: 27759; Mature: 27759

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00171 TIM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTFLAGNWKMHYTSAEASIVAKKIATEVKTLKDDVVIMITPPFTALSKVSECIKGSNI
CCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCE
LLGAQNMSYMESGARTSEISPSMLLEFGVEYVILGHSECRLYLAETDEIINKKILAGLKH
EEECCCCHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHC
PFKYLILCVGETLDERDSGKTLEVVLNQVKKGLNCVSESDIQRIILAYEPVWAIGTGKTA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEECCEEEECCCCCC
TKEEAEEVHKAIRLEITKLYSKSASDNIIIQYGGSVNSNNVKELMNEPNIDGALIGGASL
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEEECCCHH
KAESFLSIINNVL
HHHHHHHHHHHCC
>Mature Secondary Structure
MRKTFLAGNWKMHYTSAEASIVAKKIATEVKTLKDDVVIMITPPFTALSKVSECIKGSNI
CCCEEEECCCEEEEECCHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCE
LLGAQNMSYMESGARTSEISPSMLLEFGVEYVILGHSECRLYLAETDEIINKKILAGLKH
EEECCCCHHHHCCCCCCCCCHHHHHHCCCCEEEEECCCEEEEEECHHHHHHHHHHHHHHC
PFKYLILCVGETLDERDSGKTLEVVLNQVKKGLNCVSESDIQRIILAYEPVWAIGTGKTA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEECCEEEECCCCCC
TKEEAEEVHKAIRLEITKLYSKSASDNIIIQYGGSVNSNNVKELMNEPNIDGALIGGASL
CHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCEEEECCCHH
KAESFLSIINNVL
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA