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The map label for this gene is parC

Identifier: 15594381

GI number: 15594381

Start: 32157

End: 34037

Strand: Reverse

Name: parC

Synonym: BB0035

Alternate gene names: 15594381

Gene position: 34037-32157 (Counterclockwise)

Preceding gene: 15594382

Following gene: 15594380

Centisome position: 3.74

GC content: 27.8

Gene sequence:

>1881_bases
ATGGATATTAGAACTGTACTTAAAGATAATTTTTTGCAATATTCATCTTATGTTATTAAAGATCGTGCTATTGCTAGTGT
TGTTGATGGGTTTAAACCAGTTCAAAGGAGAATTATACATTCTCTTTTTGAAATGCATGATGGCAACTTTCATAAAGTTG
CAAATGTTGTTGGTAATACAATGAAATATCATCCCCACGGCGATACGTCAATTTATGAGGCTCTTGTTAATATTGCCAAT
AAGGATCTATTTATTGAAAAGCAGGGCAATTTTGGCAATTTATTCACAGGTGATCCTGCTTCTGCTTCTAGATATATTGA
ATGTAGGCTAACTCCCTTAGCCTTTGATGTTCTTTACAGCAAAGAGATAACAATTTATGAATCTTCTTATGATGGAAGAA
ATAATGAACCTTTGCTTTATCCTGCCAAAATTCCTGTTATTTTAATTCAAGGAAGTGAGGGAATTGCTGTTGGAATGGCA
GCTAAAATATTGCCTCACAATTTTAATGAGATTTTAAATGCAGTAAAGAGCGAGCTTCTTGGAGAGAGTTATGATATTTA
TCCTGATTTTCCAACGGGAGGAATAGTTGATGTTAACGAATACGCTGATGGTAACGGTAAAGTTTTAGTTAGAGCTAAGA
TTGAAACCATAGATGAAAAAACAATTGTAATAAGGGAATTACCCTTTGGTGAGACTACTGAGAGCTTAATATCTTCGATT
GAGAAAGCAATTAGAAAAAATTATATTAAAGTTTCAAGCATTAATGACTTTACTGCTGAAAATGTGGCCATAGAGCTATC
TTTGCCTAGGGGTGTTTATGCAAGCGAAGTGATTGAAAAGTTGTATCATTATACAAATTGTCAGATATCAATTTCTGTTA
ATTTATTATTGCTTAGCGAGAGATATCCTGTTGTTTATACTATTAAAGATCTTATCAAGTTTCATGCAGCCCATCTTCAA
AAAATTTTAAAAATGGAACTTGAATTACAAAAAAGCAAGATTCTTGAAAAAATATTTTATAAAACACTCGAGCAAATTTT
TATTGAAAAAAAGATTTATAAACTTCTTGAAACAATTTCTAAAGAAGAAAATATTCTAAGTATAATATTGTCAGAGGTTT
TAAGGCACAAAGAATCTTTTTCAAGGGAAGTTTTAAAAGAAGATGTTGAAAATTTGCTTAAAATTCCAATTAGAAAAATA
AGTCTTTTTGATATTGATAAGAATTCTAAGGATATTAAAATTTTAAATAAAGAATTAAAGAGTATAAATAGCAATATTTC
TTCAATAAGAGGTTATTCAATAAATTTTATTGATTTATTGCTTGCAAAGTATTCTAAAGAGCATCAAAGAAAGACTAAAA
TTTCTTTAATCAAATCAAAGAATGTAAAAGAAATAGCTACAAAGAATATGAAAGTTTATTTGAACTTGGCAGAAGGCTTT
GCAGGAACAAGTCTTTTTGATGGTGAATTTATTGGAAATGCTAGTTATTATGATAAAATATTAGTTTTTAGAGAAAATAG
TTATGTTCTTAAAAATATTGAAGACAAGACATTTATAGATAAAAAGAATGTATGTGCTTTAGTTTATGATATAAATAATT
CAAAAGAGCAAATATTTTCAATAATTTATTTTAACAGGCTTGACAATTTTTATTATGTTAAAAGGTTTAAAATAGATAAA
TTTATTACAGATAAGGTTTATGAATTCTTGGGAGAAAATGATGAATTTGTCGATTTTTCATTGAATCCAGAATTTGTAGA
ATTTTCTACAAATAAAGACATTGTTAAAAGAATTGAAATTGATAATTTTATGGTCAAATCAAGAAGCTCTATTGGGAAGC
GAATTTCAAGCAATAATTTGAAAAAAGTTAAATTTAAATAA

Upstream 100 bases:

>100_bases
TGGACCTTTTTAATATTAAAGAAATAAAAGAGAAATTGGGTTTTTATATGGGGCAAAATACTCCTGAGAGGCGGAATTTT
ATTATGGAGAATTTGATTTA

Downstream 100 bases:

>100_bases
CTTTAAAAACCTTTTTTAAATTTCATTAATATGCTACCATAGTACCAGTTTTAATAAAGGGGTTTTTATGAATAAACTTT
TAATTTTTGTTTTGGCAACC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNTMKYHPHGDTSIYEALVNIAN
KDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYSKEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILNAVKSELLGESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSI
EKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSERYPVVYTIKDLIKFHAAHLQ
KILKMELELQKSKILEKIFYKTLEQIFIEKKIYKLLETISKEENILSIILSEVLRHKESFSREVLKEDVENLLKIPIRKI
SLFDIDKNSKDIKILNKELKSINSNISSIRGYSINFIDLLLAKYSKEHQRKTKISLIKSKNVKEIATKNMKVYLNLAEGF
AGTSLFDGEFIGNASYYDKILVFRENSYVLKNIEDKTFIDKKNVCALVYDINNSKEQIFSIIYFNRLDNFYYVKRFKIDK
FITDKVYEFLGENDEFVDFSLNPEFVEFSTNKDIVKRIEIDNFMVKSRSSIGKRISSNNLKKVKFK

Sequences:

>Translated_626_residues
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNTMKYHPHGDTSIYEALVNIAN
KDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYSKEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILNAVKSELLGESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSI
EKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSERYPVVYTIKDLIKFHAAHLQ
KILKMELELQKSKILEKIFYKTLEQIFIEKKIYKLLETISKEENILSIILSEVLRHKESFSREVLKEDVENLLKIPIRKI
SLFDIDKNSKDIKILNKELKSINSNISSIRGYSINFIDLLLAKYSKEHQRKTKISLIKSKNVKEIATKNMKVYLNLAEGF
AGTSLFDGEFIGNASYYDKILVFRENSYVLKNIEDKTFIDKKNVCALVYDINNSKEQIFSIIYFNRLDNFYYVKRFKIDK
FITDKVYEFLGENDEFVDFSLNPEFVEFSTNKDIVKRIEIDNFMVKSRSSIGKRISSNNLKKVKFK
>Mature_626_residues
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNTMKYHPHGDTSIYEALVNIAN
KDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYSKEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMA
AKILPHNFNEILNAVKSELLGESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSI
EKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSERYPVVYTIKDLIKFHAAHLQ
KILKMELELQKSKILEKIFYKTLEQIFIEKKIYKLLETISKEENILSIILSEVLRHKESFSREVLKEDVENLLKIPIRKI
SLFDIDKNSKDIKILNKELKSINSNISSIRGYSINFIDLLLAKYSKEHQRKTKISLIKSKNVKEIATKNMKVYLNLAEGF
AGTSLFDGEFIGNASYYDKILVFRENSYVLKNIEDKTFIDKKNVCALVYDINNSKEQIFSIIYFNRLDNFYYVKRFKIDK
FITDKVYEFLGENDEFVDFSLNPEFVEFSTNKDIVKRIEIDNFMVKSRSSIGKRISSNNLKKVKFK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913408, Length=230, Percent_Identity=32.1739130434783, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19913406, Length=233, Percent_Identity=30.9012875536481, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1788562, Length=359, Percent_Identity=33.1476323119777, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1789396, Length=359, Percent_Identity=30.9192200557103, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI17535065, Length=230, Percent_Identity=29.1304347826087, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=228, Percent_Identity=26.7543859649123, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=165, Percent_Identity=26.6666666666667, Blast_Score=73, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=245, Percent_Identity=26.9387755102041, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=229, Percent_Identity=28.82096069869, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136538, Length=245, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PARC_BORBU (O51066)

Other databases:

- EMBL:   AE000783
- PIR:   C70104
- RefSeq:   NP_212169.1
- ProteinModelPortal:   O51066
- EnsemblBacteria:   EBBORT00000008693
- GeneID:   1194871
- GenomeReviews:   AE000783_GR
- KEGG:   bbu:BB0035
- NMPDR:   fig|224326.1.peg.419
- TIGR:   BB_0035
- GeneTree:   EBGT00050000007271
- HOGENOM:   HBG302029
- OMA:   TKILPHN
- ProtClustDB:   PRK09631
- BioCyc:   BBUR224326:BB_0035-MONOMER
- GO:   GO:0005694
- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- SMART:   SM00434

Pfam domain/function: PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: 5.99.1.-

Molecular weight: Translated: 72043; Mature: 72043

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: NA

Important sites: ACT_SITE 105-105

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
MKYHPHGDTSIYEALVNIANKDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYS
EEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEC
KEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMAAKILPHNFNEILNAVKSELL
CEEEEEECCCCCCCCCCEEEECCCCEEEEECCCCEEEHHHHHHCCCCHHHHHHHHHHHHC
GESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSI
CCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHH
EKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSE
HHHHHHCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEC
RYPVVYTIKDLIKFHAAHLQKILKMELELQKSKILEKIFYKTLEQIFIEKKIYKLLETIS
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEENILSIILSEVLRHKESFSREVLKEDVENLLKIPIRKISLFDIDKNSKDIKILNKELK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
SINSNISSIRGYSINFIDLLLAKYSKEHQRKTKISLIKSKNVKEIATKNMKVYLNLAEGF
HHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCC
AGTSLFDGEFIGNASYYDKILVFRENSYVLKNIEDKTFIDKKNVCALVYDINNSKEQIFS
CCCCEECCCCCCCCCHHEEEEEEECCCEEEECCCCCCEECCCCCEEEEEECCCCHHHHHH
IIYFNRLDNFYYVKRFKIDKFITDKVYEFLGENDEFVDFSLNPEFVEFSTNKDIVKRIEI
HHHHHHCCCEEEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHH
DNFMVKSRSSIGKRISSNNLKKVKFK
HHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MDIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEMHDGNFHKVANVVGNT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCC
MKYHPHGDTSIYEALVNIANKDLFIEKQGNFGNLFTGDPASASRYIECRLTPLAFDVLYS
EEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCEEEEEECCEEEEEEEC
KEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMAAKILPHNFNEILNAVKSELL
CEEEEEECCCCCCCCCCEEEECCCCEEEEECCCCEEEHHHHHHCCCCHHHHHHHHHHHHC
GESYDIYPDFPTGGIVDVNEYADGNGKVLVRAKIETIDEKTIVIRELPFGETTESLISSI
CCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEEEECCCCCCHHHHHHHH
EKAIRKNYIKVSSINDFTAENVAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSE
HHHHHHCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEEC
RYPVVYTIKDLIKFHAAHLQKILKMELELQKSKILEKIFYKTLEQIFIEKKIYKLLETIS
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
KEENILSIILSEVLRHKESFSREVLKEDVENLLKIPIRKISLFDIDKNSKDIKILNKELK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHH
SINSNISSIRGYSINFIDLLLAKYSKEHQRKTKISLIKSKNVKEIATKNMKVYLNLAEGF
HHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEECCCC
AGTSLFDGEFIGNASYYDKILVFRENSYVLKNIEDKTFIDKKNVCALVYDINNSKEQIFS
CCCCEECCCCCCCCCHHEEEEEEECCCEEEECCCCCCEECCCCCEEEEEECCCCHHHHHH
IIYFNRLDNFYYVKRFKIDKFITDKVYEFLGENDEFVDFSLNPEFVEFSTNKDIVKRIEI
HHHHHHCCCEEEEEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCEEEECCCHHHHHHHHH
DNFMVKSRSSIGKRISSNNLKKVKFK
HHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9403685