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The map label for this gene is coaA

Identifier: 50812263

GI number: 50812263

Start: 2468549

End: 2469508

Strand: Reverse

Name: coaA

Synonym: BSU23760

Alternate gene names: 50812263

Gene position: 2469508-2468549 (Counterclockwise)

Preceding gene: 255767515

Following gene: 16079432

Centisome position: 58.58

GC content: 43.44

Gene sequence:

>960_bases
GTGAAAAATAAAGAACTTAACCTACATACTTTATATACACAGCACAATCGGGAGTCTTGGTCTGGTTTTGGGGGGCATTT
GTCGATTGCTGTATCTGAAGAAGAGGCAAAAGCTGTGGAAGGATTGAATGATTATCTATCTGTTGAAGAAGTGGAGACGA
TCTATATTCCGCTTGTTCGCTTGCTTCATTTACATGTCAAGTCTGCGGCTGAACGCAATAAGCATGTCAATGTTTTTTTG
AAGCACCCACATTCAGCCAAAATTCCGTTTATTATCGGCATTGCCGGCAGTGTCGCAGTCGGAAAAAGCACGACGGCGCG
GATCTTGCAGAAGCTGCTTTCGCGTTTGCCTGACCGTCCAAAAGTGAGCCTTATCACGACAGATGGTTTTTTATTTCCTA
CTGCCGAGCTGAAAAAGAAAAATATGATGTCAAGAAAAGGATTTCCTGAAAGCTATGATGTAAAGGCGCTGCTCGAATTT
TTGAATGACTTAAAATCAGGAAAGGACAGCGTAAAGGCCCCGGTGTATTCCCATCTAACCTATGACCGCGAGGAAGGTGT
GTTCGAGGTTGTAGAACAGGCGGATATTGTGATTATTGAAGGCATTAATGTTCTTCAGTCGCCCACCTTGGAGGATGACC
GGGAAAACCCGCGTATTTTTGTTTCCGATTTCTTTGATTTTTCGATTTATGTGGATGCGGAGGAAAGCCGGATTTTCACT
TGGTATTTAGAGCGTTTTCGCCTGCTTCGGGAAACAGCTTTTCAAAATCCTGATTCATATTTTCATAAATTTAAAGACTT
GTCCGATCAGGAGGCTGACGAGATGGCAGCCTCGATTTGGGAGAGTGTCAACCGGCCGAATTTATATGAAAATATTTTGC
CAACTAAATTCAGGTCAGATCTCATTTTGCGTAAGGGAGACGGGCATAAGGTCGAGGAAGTGTTGGTAAGGAGGGTATGA

Upstream 100 bases:

>100_bases
ATTTGCTAAAAAAACGAAATGAAAAATAAGCAGACAGTGAAAAGGTTTTCCGTTACAATCTTTGTAAGGGTTTTAACCTA
CAGAGAGTCAGGTGTAAACA

Downstream 100 bases:

>100_bases
AATGTGCATCATATTGAACTGTATGTCTCTGATTTGGAGGCGTCTAGGCGGTTTTGGGGCTGGTTCTTAAAAGAACTTGG
TTATAAAGAGTATCAAAAAT

Product: pantothenate kinase

Products: NA

Alternate protein names: Pantothenic acid kinase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF
LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV

Sequences:

>Translated_319_residues
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF
LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV
>Mature_319_residues
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFL
KHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF
LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFT
WYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV

Specific function: Coenzyme A (CoA) biosynthesis; first step. [C]

COG id: COG1072

COG function: function code H; Panthothenate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic pantothenate kinase family [H]

Homologues:

Organism=Homo sapiens, GI18699734, Length=233, Percent_Identity=27.8969957081545, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI301129207, Length=236, Percent_Identity=25.8474576271186, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI57863312, Length=236, Percent_Identity=25.8474576271186, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790409, Length=318, Percent_Identity=49.685534591195, Blast_Score=301, Evalue=4e-83,
Organism=Drosophila melanogaster, GI45550449, Length=228, Percent_Identity=28.0701754385965, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573516, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573514, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28573512, Length=228, Percent_Identity=28.0701754385965, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004566
- InterPro:   IPR006083 [H]

Pfam domain/function: PF00485 PRK [H]

EC number: =2.7.1.33 [H]

Molecular weight: Translated: 36640; Mature: 36640

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVR
CCCCCEEEEEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRP
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCC
KVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEFLNDLKSGKDSVKAPVYSHLT
CEEEEEECCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHCCCHHHHCC
YDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFT
CCCCCCHHHHHHCCCEEEEECCHHHCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHH
WYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSD
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHCC
LILRKGDGHKVEEVLVRRV
EEEECCCCCHHHHHHHHCC
>Mature Secondary Structure
MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLNDYLSVEEVETIYIPLVR
CCCCCEEEEEEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGKSTTARILQKLLSRLPDRP
HHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEECCCEEECCCHHHHHHHHHHHHCCCCC
KVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEFLNDLKSGKDSVKAPVYSHLT
CEEEEEECCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHCCCHHHHCC
YDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPRIFVSDFFDFSIYVDAEESRIFT
CCCCCCHHHHHHCCCEEEEECCHHHCCCCCCCCCCCCEEEEEEEEEEEEEEECCCCCHHH
WYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMAASIWESVNRPNLYENILPTKFRSD
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHCCHHHHCC
LILRKGDGHKVEEVLVRRV
EEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA