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The map label for this gene is hutM

Identifier: 255767836

GI number: 255767836

Start: 4047538

End: 4048965

Strand: Direct

Name: hutM

Synonym: BSU39390

Alternate gene names: 255767836

Gene position: 4047538-4048965 (Clockwise)

Preceding gene: 16080989

Following gene: 16081009

Centisome position: 96.01

GC content: 44.75

Gene sequence:

>1428_bases
GTGAATCTTCAGGAGAACAGCAGCCAACAGCTAAAACGCACAATGAAAAGCAGGCACCTATTTATGATCTCATTGGGAGG
CGTCATAGGCACAGGACTTTTCCTCAGTACGGGCTATACGCTACATCAAGCCGGACCCGGCGGTACGATACTCGCTTATG
TAATCGGCGGGTTGATGATGTACCTCGTCATGCAATGTCTCGGCGAATTGTCGGTTGCCATGCCGGTGACCGGCTCTTTT
CAAAAATATGCTACAACATTTATCGGTCCATCTACCGGTTTTATGGTCGGCATCATGTACTGGATCAATTGGGTGGTGAC
GGTAGGCTCTGAGTTTACCGCATCCGGTATTCTCATGCAGCGCTGGTTCCCTGACAGCAGTGTATGGATGTGGAGTGCGA
TTTTTGCAGCCCTTCTTTTTATATGCAACGCATTTTCAGTTAAGTTATTTGCGGAAACTGAATTTTGGTTTTCCAGCGTA
AAGATTGTCACCATTATTTTATTTATCATTTTAGGAGGAGCCGCCATGTTTGGCCTGATCTCTTTAAACGGAACGGCGGA
TGCTCCTATGTTGTCAAACTTCACAGATCATGGCGGGTTGTTTCCAAATGGCTTTCTCGCCGTTTTTATCGCGATGATAT
CTGTGAGCTTCGCCTTTTCCGGTACAGAGTTAATCGGCGTTACAGCAGGAGAATCAGCAAATCCTCAAAAGGATATACCG
CGATCCATCCGTAATGTCGCATGGAGAACCGTGATTTTTTTCATTGGCGCTGTCTTCATATTATCCGGGTTGATTTCATG
GAAGGACGCAGGCGTGATTGAAAGCCCGTTTGTCGCCGTATTTGCGGAGATCGGAATTCCTTACGCTGCTGATATTATGA
ATTTCGTAATATTAACAGCCTTGCTGTCTGTCGCCAACTCAGGCTTATATGCTTCGACCCGTATGATGTGGTCTTTAGCA
AATGAAAACATGATCAGCTCCCGTTTTAAGAAAGTGACATCTAAAGGCATTCCTTTAAATGCCTTAATGATCAGTATGGC
TGTATCTTGTTTATCTCTCGTTTCCAGTATCGTGGCCCCTGGAACTGTCTATGTGGTGATGGTCGCAATTGCTGGATTTG
CAGGAGTCGTGGTCTGGATGAGCATTGCCTTGTCCCAACTCTTGTTTCGAAAGAGATTTTTGAAAAAAGGGGGGGATGTA
AAAGATCTGACATTTCGCACGCCGCTTTATCCTCTTATGCCTATAGCCGCTCTCTTATTATGTTCTGCTTCTTGTATCGG
TCTTGCTTTTGATCCCAATCAAAGAATCGCACTTTTCTGCGGAGTTCCTTGTATCATCCTTTGCTATCTCATCTACCATT
TCAAAAGAAATGTTACAAAAGCGAAAAAAATCAGCCAAGAGGAATATCCAGCCGATCACATCCTATAA

Upstream 100 bases:

>100_bases
AATGAAACTCTCCCCATTCAAGTGATCTTCTGGCAGGTTGTATTTTGGGTATAAGAAACTCATCTGCCTAAGGAATGGCA
GCTAAAAGGAGGGCGAGACA

Downstream 100 bases:

>100_bases
TTAAAAAAGCACACCCCGCTCAGCATGGGATGTGCTTTATTTTTTATTCTGTAATTAACGTATGAATCAGCTTCGGCGCC
TTCGCTTCCGCGGCGATGCG

Product: histidine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQAGPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSF
QKYATTFIGPSTGFMVGIMYWINWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV
KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFAFSGTELIGVTAGESANPQKDIP
RSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESPFVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLA
NENMISSRFKKVTSKGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKRFLKKGGDV
KDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYLIYHFKRNVTKAKKISQEEYPADHIL

Sequences:

>Translated_475_residues
MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQAGPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSF
QKYATTFIGPSTGFMVGIMYWINWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV
KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFAFSGTELIGVTAGESANPQKDIP
RSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESPFVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLA
NENMISSRFKKVTSKGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKRFLKKGGDV
KDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYLIYHFKRNVTKAKKISQEEYPADHIL
>Mature_475_residues
MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQAGPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSF
QKYATTFIGPSTGFMVGIMYWINWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV
KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFAFSGTELIGVTAGESANPQKDIP
RSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESPFVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLA
NENMISSRFKKVTSKGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKRFLKKGGDV
KDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYLIYHFKRNVTKAKKISQEEYPADHIL

Specific function: Transporter For The Intake Of S-Methylmethionine. [C]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily

Homologues:

Organism=Homo sapiens, GI110347453, Length=353, Percent_Identity=22.0963172804533, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI87081708, Length=471, Percent_Identity=54.9893842887473, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1788480, Length=486, Percent_Identity=38.0658436213992, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI1786302, Length=459, Percent_Identity=35.7298474945534, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI48994972, Length=469, Percent_Identity=35.8208955223881, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1786789, Length=407, Percent_Identity=36.1179361179361, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1786602, Length=465, Percent_Identity=36.1290322580645, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI87081915, Length=436, Percent_Identity=34.4036697247706, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789017, Length=451, Percent_Identity=32.3725055432373, Blast_Score=248, Evalue=5e-67,
Organism=Escherichia coli, GI1790653, Length=441, Percent_Identity=32.6530612244898, Blast_Score=244, Evalue=6e-66,
Organism=Caenorhabditis elegans, GI17540018, Length=369, Percent_Identity=24.6612466124661, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=422, Percent_Identity=32.4644549763033, Blast_Score=239, Evalue=7e-64,
Organism=Saccharomyces cerevisiae, GI6320772, Length=424, Percent_Identity=32.7830188679245, Blast_Score=239, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6324553, Length=408, Percent_Identity=33.578431372549, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6324059, Length=425, Percent_Identity=31.7647058823529, Blast_Score=209, Evalue=7e-55,
Organism=Saccharomyces cerevisiae, GI6322892, Length=408, Percent_Identity=32.3529411764706, Blast_Score=206, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6319543, Length=416, Percent_Identity=29.3269230769231, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6321629, Length=416, Percent_Identity=31.25, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=27.1805273833671, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=419, Percent_Identity=28.1622911694511, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6324924, Length=418, Percent_Identity=29.4258373205742, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322967, Length=426, Percent_Identity=30.5164319248826, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6319824, Length=417, Percent_Identity=28.537170263789, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=416, Percent_Identity=29.8076923076923, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=415, Percent_Identity=29.6385542168675, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321053, Length=469, Percent_Identity=26.0127931769723, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6324981, Length=497, Percent_Identity=29.5774647887324, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6319608, Length=436, Percent_Identity=24.5412844036697, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=22.3762376237624, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221331183, Length=326, Percent_Identity=24.2331288343558, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI17647653, Length=326, Percent_Identity=24.2331288343558, Blast_Score=66, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24664379, Length=326, Percent_Identity=24.2331288343558, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTM_BACSU (P42087)

Other databases:

- EMBL:   D31856
- EMBL:   AL009126
- EMBL:   X82174
- EMBL:   D45912
- PIR:   E69643
- RefSeq:   NP_391818.2
- ProteinModelPortal:   P42087
- EnsemblBacteria:   EBBACT00000001962
- GeneID:   938565
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU39390
- NMPDR:   fig|224308.1.peg.3944
- GenoList:   BSU39390
- GeneTree:   EBGT00070000031736
- HOGENOM:   HBG492579
- PhylomeDB:   P42087
- ProtClustDB:   CLSK888150
- BioCyc:   BSUB:BSU39390-MONOMER
- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- PANTHER:   PTHR11785
- PIRSF:   PIRSF006060

Pfam domain/function: PF00324 AA_permease

EC number: NA

Molecular weight: Translated: 51625; Mature: 51625

Theoretical pI: Translated: 9.16; Mature: 9.16

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1313ab9c)-; HASH(0x1317b1cc)-; HASH(0x134b105c)-; HASH(0x134f8d38)-; HASH(0x1320e60c)-; HASH(0x1340ca6c)-; HASH(0x12953654)-; HASH(0x12ffb284)-; HASH(0x12e0423c)-; HASH(0x1367bc8c)-; HASH(0x13435188)-; HASH(0x1352f5d8)-;

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQAGPGGTILAYVIGGLMM
CCCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
YLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWINWVVTVGSEFTASGILMQ
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHH
RWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSVKIVTIILFIILGGAAMFGLI
HCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFAFSGTELIGVTAGESANPQKDIP
EECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
RSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESPFVAVFAEIGIPYAADIMNFVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LLSVANSGLYASTRMMWSLANENMISSRFKKVTSKGIPLNALMISMAVSCLSLVSSIVAP
HHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
GTVYVVMVAIAGFAGVVVWMSIALSQLLFRKRFLKKGGDVKDLTFRTPLYPLMPIAALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHH
CSASCIGLAFDPNQRIALFCGVPCIILCYLIYHFKRNVTKAKKISQEEYPADHIL
HHHHHHEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCH
>Mature Secondary Structure
MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQAGPGGTILAYVIGGLMM
CCCCCCCHHHHHHHHHHCCEEEEEECHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
YLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWINWVVTVGSEFTASGILMQ
HHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCHHHCCHHHH
RWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSVKIVTIILFIILGGAAMFGLI
HCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFAFSGTELIGVTAGESANPQKDIP
EECCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
RSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESPFVAVFAEIGIPYAADIMNFVILTA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHH
LLSVANSGLYASTRMMWSLANENMISSRFKKVTSKGIPLNALMISMAVSCLSLVSSIVAP
HHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
GTVYVVMVAIAGFAGVVVWMSIALSQLLFRKRFLKKGGDVKDLTFRTPLYPLMPIAALLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHH
CSASCIGLAFDPNQRIALFCGVPCIILCYLIYHFKRNVTKAKKISQEEYPADHIL
HHHHHHEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704263; 9384377; 8550462; 8867804