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The map label for this gene is murAB

Identifier: 255767788

GI number: 255767788

Start: 3806086

End: 3807375

Strand: Reverse

Name: murAB

Synonym: BSU37100

Alternate gene names: 255767788

Gene position: 3807375-3806086 (Counterclockwise)

Preceding gene: 255767789

Following gene: 16080762

Centisome position: 90.32

GC content: 50.16

Gene sequence:

>1290_bases
ATGGAAAAGTTGAATATTGCCGGCGGTGACTCGTTAAACGGTACAGTACATATCAGCGGCGCTAAAAACAGCGCTGTTGC
GTTAATACCTGCAACCATTTTGGCAAATTCCGAGGTGACAATTGAAGGGCTTCCAGAGATTTCAGATATTGAAACGCTGC
GTGACCTGTTAAAGGAAATCGGCGGCAACGTGCATTTTGAGAATGGGGAAATGGTTGTTGACCCTACGTCGATGATCAGC
ATGCCGCTTCCTAACGGGAAAGTAAAAAAGCTTCGCGCGTCATATTATTTAATGGGGGCGATGCTCGGCCGCTTCAAGCA
GGCGGTCATTGGATTGCCTGGCGGCTGTCACTTAGGGCCCCGTCCGATTGATCAGCATATCAAAGGCTTTGAAGCACTCG
GAGCTGAAGTAACCAATGAACAAGGCGCCATTTATTTGCGAGCTGAAAGGCTGAGAGGCGCACGGATTTATTTAGATGTC
GTAAGCGTTGGGGCAACGATTAACATTATGCTCGCCGCTGTTTTGGCAGAAGGGAAAACGATCATCGAAAACGCTGCCAA
GGAGCCTGAGATCATTGACGTCGCGACATTGCTTACCAGCATGGGCGCCAAAATCAAAGGTGCGGGCACCAATGTGATTC
GAATCGACGGCGTGAAGGAACTGCACGGCTGCAAGCATACGATCATTCCGGACAGAATTGAAGCCGGGACATTTATGATT
GCAGGGGCTGCAATGGGCAAGGAAGTCATTATCGATAACGTCATCCCTACTCATCTTGAGTCGTTAACGGCAAAGCTGAG
AGAAATGGGCTATCATATCGAAACAAGCGACGACCAGCTCCTCATTGTCGGCGGGCAGAAGAACTTAAAGCCGGTTGACG
TCAAAACCCTCGTATACCCGGGGTTTCCGACTGATTTACAGCAGCCGATGACGGCGCTCCTGACAAGGGCGAAAGGGACG
AGTGTCGTCACAGACACCATCTACTCGGCAAGATTCAAGCACATTGATGAGCTGAGACGAATGGGTGCCAATATGAAAGT
AGAAGGCAGATCTGCCATCATCACAGGTCCTGTCGAGCTTCAAGGCGCAAAAGTGAAGGCGAGTGATCTGCGTGCCGGAG
CCTGCTTGGTGGTAGCCGGACTGATGGCTGATGGCGTCACGGAAATTACGGGACTGGAGCATATTGACCGAGGATACAGC
AGCCTTGAGAAGAAGCTTGAGGGGCTTGGAGCGACAATTTGGCGTGAAAGAATGACTGACGAAGAAATAGAACAGCTTCA
AAATTCATAA

Upstream 100 bases:

>100_bases
CGAATTGGCTAGATTTTGGACATGAGCTTTATTTGCAGAGACAGAATAAAATGACATTTTATTTAGCTCCGCAGCTATCT
TCTTATGGAAGGAGACTATC

Downstream 100 bases:

>100_bases
TGGTTTCTTGTGAGAGGAGATCGTGTTGAAATGGAAAGAAGTTTATCAATGGAATTGGTACGTGTGACAGAAGCTGCGGC
ATTGGCATCAGCAAGATGGA

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 2; UDP-N-acetylglucosamine enolpyruvyl transferase 2; EPT 2

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMIS
MPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV
VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMI
AGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGT
SVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYS
SLEKKLEGLGATIWRERMTDEEIEQLQNS

Sequences:

>Translated_429_residues
MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMIS
MPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV
VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMI
AGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGT
SVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYS
SLEKKLEGLGATIWRERMTDEEIEQLQNS
>Mature_429_residues
MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMIS
MPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV
VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMI
AGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGT
SVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYS
SLEKKLEGLGATIWRERMTDEEIEQLQNS

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=418, Percent_Identity=44.9760765550239, Blast_Score=350, Evalue=9e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA2_BACSU (P19670)

Other databases:

- EMBL:   Z49782
- EMBL:   AL009126
- EMBL:   M22039
- EMBL:   M97678
- PIR:   S55428
- RefSeq:   NP_391591.2
- ProteinModelPortal:   P19670
- SMR:   P19670
- EnsemblBacteria:   EBBACT00000001546
- GeneID:   937038
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU37100
- NMPDR:   fig|224308.1.peg.3717
- GenoList:   BSU37100
- GeneTree:   EBGT00050000001036
- HOGENOM:   HBG482701
- ProtClustDB:   PRK12830
- BioCyc:   BSUB:BSU37100-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 46001; Mature: 46001

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: NA

Important sites: ACT_SITE 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEI
CCCEECCCCCCCCCEEEEECCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHH
GGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGP
CCCEEEECCCEEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDVVSVGATINIMLAAVLAEGKT
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCHH
IIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMI
HHHHCCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEEE
AGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYP
EECCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCEEEEEEC
GFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVEL
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCEEE
QGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYSSLEKKLEGLGATIWRERMTD
CCCEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
EEIEQLQNS
HHHHHHHCC
>Mature Secondary Structure
MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGLPEISDIETLRDLLKEI
CCCEECCCCCCCCCEEEEECCCCCEEEEEEEEEEECCCEEECCCCCHHHHHHHHHHHHHH
GGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAMLGRFKQAVIGLPGGCHLGP
CCCEEEECCCEEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDVVSVGATINIMLAAVLAEGKT
CCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHCCHH
IIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGVKELHGCKHTIIPDRIEAGTFMI
HHHHCCCCCCHHHHHHHHHHCCCEEECCCCCEEEECCCHHHHCCCCCCCCCCCCCCEEEE
AGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETSDDQLLIVGGQKNLKPVDVKTLVYP
EECCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEECCCCEEEEECCCCCCCCCCEEEEEEC
GFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKHIDELRRMGANMKVEGRSAIITGPVEL
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEEECCEEE
QGAKVKASDLRAGACLVVAGLMADGVTEITGLEHIDRGYSSLEKKLEGLGATIWRERMTD
CCCEEEHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCH
EEIEQLQNS
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377; 2457578; 8423140