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The map label for this gene is bioW

Identifier: 255767694

GI number: 255767694

Start: 3094679

End: 3095455

Strand: Reverse

Name: bioW

Synonym: BSU30240

Alternate gene names: 255767694

Gene position: 3095455-3094679 (Counterclockwise)

Preceding gene: 16080077

Following gene: 16080075

Centisome position: 73.43

GC content: 43.89

Gene sequence:

>777_bases
ATGCAAGAAGAAACTTTTTATAGTGTCAGAATGAGGGCTTCAATGAATGGATCTCATGAAGACGGCGGAAAGCATATATC
CGGCGGAGAACGGCTTATTCCTTTCCATGAGATGAAGCATACAGTCAATGCTTTATTAGAAAAAGGGTTATCCCATTCAA
GAGGAAAACCTGATTTTATGCAAATTCAATTTGAAGAGGTACATGAATCGATAAAAACCATTCAGCCATTGCCTGTGCAT
ACGAATGAAGTGAGCTGCCCGGAAGAAGGACAAAAGCTTGCCCGATTGTTATTGGAAAAAGAAGGCGTTTCACGAGACGT
GATTGAAAAAGCATATGAACAAATCCCTGAATGGTCAGATGTCAGGGGTGCGGTGTTGTTTGATATTCATACAGGCAAGC
GAATGGATCAAACAAAAGAAAAAGGGGTGCGGGTCTCCAGAATGGATTGGCCGGACGCTAATTTTGAAAAATGGGCGCTT
CACAGTCACGTGCCAGCTCATTCAAGAATAAAAGAGGCCCTTGCGCTCGCTTCAAAGGTAAGCCGGCACCCGGCAGTCGT
TGCAGAATTATGCTGGTCGGACGATCCGGATTACATAACAGGCTATGTTGCGGGTAAGAAAATGGGCTATCAGCGTATTA
CAGCAATGAAAGAATACGGGACTGAAGAGGGCTGCCGAGTCTTTTTTATTGATGGATCCAATGATGTAAACACGTACATA
CATGACCTGGAGAAGCAGCCTATTTTAATAGAGTGGGAGGAAGATCATGACTCATGA

Upstream 100 bases:

>100_bases
AATAATATATTCTAATTGTTAACCTTTGAATATAATTGGTTAACAATTTAGGTGAGAAGCGCTACACGTTCTTCAGTTAT
CAGTGAAAGGGCGAGAAATG

Downstream 100 bases:

>100_bases
TTTGATAGAAAAAAGTAAAAAGCACCTCTGGCTGCCATTTACCCAAATGAAAGATTATGATGAAAACCCCTTAATCATCG
AAAGCGGGACTGGAATCAAA

Product: 6-carboxyhexanoate--CoA ligase

Products: NA

Alternate protein names: Pimeloyl-CoA synthase

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVH
TNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL
HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYI
HDLEKQPILIEWEEDHDS

Sequences:

>Translated_258_residues
MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVH
TNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL
HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYI
HDLEKQPILIEWEEDHDS
>Mature_258_residues
MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVH
TNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL
HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYI
HDLEKQPILIEWEEDHDS

Specific function: Transforms pimelate into pimeloyl-CoA

COG id: COG1424

COG function: function code H; Pimeloyl-CoA synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BioW family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOW_BACSU (P53559)

Other databases:

- EMBL:   U51868
- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   H69594
- RefSeq:   NP_390902.3
- ProteinModelPortal:   P53559
- EnsemblBacteria:   EBBACT00000002652
- GeneID:   938017
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU30240
- NMPDR:   fig|224308.1.peg.3027
- GenoList:   BSU30240
- GeneTree:   EBGT00050000002205
- HOGENOM:   HBG507782
- OMA:   TVDAIAI
- ProtClustDB:   PRK01322
- BioCyc:   BSUB:BSU30240-MONOMER
- BRENDA:   6.2.1.14
- HAMAP:   MF_00668
- InterPro:   IPR005499
- ProDom:   PD017229
- TIGRFAMs:   TIGR01204

Pfam domain/function: PF03744 BioW

EC number: =6.2.1.14

Molecular weight: Translated: 29500; Mature: 29500

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFM
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCE
QIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSD
EEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
VRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWALHSHVPAHSRIKEALALASKV
CCCEEEEEECCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
SRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYI
HCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
HDLEKQPILIEWEEDHDS
HHHCCCCEEEEECCCCCC
>Mature Secondary Structure
MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNALLEKGLSHSRGKPDFM
CCCCCEEEEEEEECCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHCCCCCCCCCCCE
QIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEGVSRDVIEKAYEQIPEWSD
EEEHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
VRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWALHSHVPAHSRIKEALALASKV
CCCEEEEEECCCCCHHHHHHHCCEEEECCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHH
SRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKEYGTEEGCRVFFIDGSNDVNTYI
HCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHH
HDLEKQPILIEWEEDHDS
HHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8763940; 9387221; 9384377