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The map label for this gene is adhA

Identifier: 255767623

GI number: 255767623

Start: 2756312

End: 2757361

Strand: Direct

Name: adhA

Synonym: BSU27010

Alternate gene names: 255767623

Gene position: 2756312-2757361 (Clockwise)

Preceding gene: 16079752

Following gene: 50812271

Centisome position: 65.38

GC content: 47.52

Gene sequence:

>1050_bases
ATGTGTAATCAACATCAAACCCGTGTATTAAGCGTGTCACATGCAAAAGCCAAATTTGAACAAACGACGATTGAGCGAAG
AGGATTACGGCCGCACGATGTCTTAATCGATATTAAATTCAGCGGCATTTGCCATTCAGACATTCATAGCGCTTTTGATG
AATGGGGCGGTGGCATCTTCCCAATGGTGCCTGGACATGAAATAGCCGGTGTTGTAACAGCCGTTGGAACAAAAGTCACC
AAGTTGGCTGTCGGGGACCGCGTTGGTGTCGGCTGTTTTGTTGACTCTTGCGGAGAATGCGAATACTGTCTCAACGCAGA
GGAACAATTCTGCACGAAGGGTGTTGTTCAAACGTATAACTCAGTAGACTACGACGGAAACCCCACTTATGGCGGGTACA
GCCAAAAAATCGTTGTCACTGACAGATTTGTTGTTCGCATACCAGATCGTTTGGAAATGGATGTTGCCAGTCCGCTGTTG
TGTGCAGGTATCACAACGTATTCCCCGCTGAAACACTGGAATGTTGGCCCTGGTAAAAAGGTTGCGATTGTAGGCGTAGG
TGGCCTTGGACATTTGGCAATTCAATTTGCACATGCGATGGGTGCAGAAGTAACCGTCCTGAGCCGTTCCATGAATAAGA
AAGAGGAAGCTCTGGAACTCGGTGCAAATCATTACTTTGCAACAAGTGACCCAGCCACATTCACTGCATTGGCCGGGCGT
TTTGACGTGATCTTAAATACGGTATCGGCAAATCTCGATGTAGATGCCTATTTATCAATGCTTCGTATAGACGGGACACT
TGTAAGCGTTGGAGCTCCTGCCAAGCCGGACACATACAGTGTGTTTTCCCTAATCATGGGGCGCCGCAGCATTGCAGGTT
CTCTAGTCGGCGGAATTCAAGAAACTCAAGAGATGCTGGATTTCGCAGCTGAGCATGGCATCGAACCTAAAATCGAAGTC
ATCGGAGCTGACCAAGTGGACGAGGCATACGAACGTATCCTCCGAAGCGATGTCCGTTATCGATTTGTGATTGATATTTC
CACATTGTAA

Upstream 100 bases:

>100_bases
GCAGACTTTAAGGTTTATCGTTATGTTGAAGACACCATAAAACATAAATAAGTGCATGTTTTTATTTACAACACTTATGA
TGAAGAAAGGATAGGTTCGT

Downstream 100 bases:

>100_bases
TAGGTTAGTCCTTATATGGGCTGCCGCTTTTATTGAAACTCACGAAAAATGATCTCTTTAAGCAAATATTTTGAAGGCCG
GTCAATCTTCCTGTTATTCT

Product: dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVT
KLAVGDRVGVGCFVDSCGECEYCLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL
CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEALELGANHYFATSDPATFTALAGR
FDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKPDTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEV
IGADQVDEAYERILRSDVRYRFVIDISTL

Sequences:

>Translated_349_residues
MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVT
KLAVGDRVGVGCFVDSCGECEYCLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL
CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEALELGANHYFATSDPATFTALAGR
FDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKPDTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEV
IGADQVDEAYERILRSDVRYRFVIDISTL
>Mature_349_residues
MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGICHSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVT
KLAVGDRVGVGCFVDSCGECEYCLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL
CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEALELGANHYFATSDPATFTALAGR
FDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKPDTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEV
IGADQVDEAYERILRSDVRYRFVIDISTL

Specific function: Functions in the protection against aldehyde-stress

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4501933, Length=373, Percent_Identity=27.8820375335121, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI71565154, Length=223, Percent_Identity=30.0448430493274, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34577061, Length=333, Percent_Identity=27.9279279279279, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI4501929, Length=331, Percent_Identity=28.3987915407855, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI156523966, Length=346, Percent_Identity=26.0115606936416, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI4501939, Length=346, Percent_Identity=26.0115606936416, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71565152, Length=313, Percent_Identity=25.2396166134185, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI71743840, Length=325, Percent_Identity=26.7692307692308, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI262073058, Length=325, Percent_Identity=26.7692307692308, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI156627571, Length=268, Percent_Identity=26.865671641791, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786518, Length=338, Percent_Identity=54.4378698224852, Blast_Score=328, Evalue=2e-91,
Organism=Escherichia coli, GI87082401, Length=318, Percent_Identity=36.7924528301887, Blast_Score=212, Evalue=4e-56,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=31.5789473684211, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1788075, Length=325, Percent_Identity=26.4615384615385, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788073, Length=199, Percent_Identity=32.1608040201005, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1788407, Length=200, Percent_Identity=32.5, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790045, Length=217, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1786552, Length=348, Percent_Identity=27.2988505747126, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790718, Length=275, Percent_Identity=28.3636363636364, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87082125, Length=282, Percent_Identity=26.5957446808511, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI226510992, Length=278, Percent_Identity=26.6187050359712, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=322, Percent_Identity=31.3664596273292, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI17562584, Length=330, Percent_Identity=30.3030303030303, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=323, Percent_Identity=31.2693498452012, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25146526, Length=206, Percent_Identity=31.5533980582524, Blast_Score=88, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=208, Percent_Identity=31.25, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=200, Percent_Identity=31.5, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562876, Length=270, Percent_Identity=25.9259259259259, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=233, Percent_Identity=30.0429184549356, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323980, Length=331, Percent_Identity=39.5770392749245, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319949, Length=319, Percent_Identity=36.6771159874608, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323961, Length=342, Percent_Identity=33.0409356725146, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=32.2674418604651, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319621, Length=354, Percent_Identity=31.9209039548023, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=30.4985337243402, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320033, Length=310, Percent_Identity=28.0645161290323, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=342, Percent_Identity=23.0994152046784, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=310, Percent_Identity=24.1935483870968, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322619, Length=279, Percent_Identity=29.0322580645161, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6319955, Length=279, Percent_Identity=29.0322580645161, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323099, Length=260, Percent_Identity=27.6923076923077, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737897, Length=202, Percent_Identity=35.1485148514851, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137530, Length=199, Percent_Identity=33.6683417085427, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17737895, Length=359, Percent_Identity=24.5125348189415, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADHA_BACSU (C0SPA5)

Other databases:

- EMBL:   X92868
- EMBL:   AL009126
- PIR:   C69583
- RefSeq:   NP_390579.2
- ProteinModelPortal:   C0SPA5
- SMR:   C0SPA5
- EnsemblBacteria:   EBBACT00000003274
- GeneID:   938739
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU27010
- GenoList:   BSU27010
- GeneTree:   EBGT00050000000383
- HOGENOM:   HBG753318
- ProtClustDB:   CLSK887648
- BioCyc:   BSUB:BSU27010-MONOMER
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR11695

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N; SSF50129 GroES_like

EC number: 1.1.1.2

Molecular weight: Translated: 37807; Mature: 37807

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGICHSDIHSAFDEWGGGIF
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCC
PMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEYCLNAEEQFCTKGVVQTYN
CCCCCHHHHHHHHHHCCHHEEEECCCCCCCEEEECCCCCCHHHCCCHHHHHHHHHHHHHC
SVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLLCAGITTYSPLKHWNVGPGKK
CCCCCCCCCCCCCCCEEEEECEEEEECCCHHCHHHCCCHHHHCCCCCCCCCCCCCCCCCE
VAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEALELGANHYFATSDPATFTALAGR
EEEEEECCHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHH
FDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKPDTYSVFSLIMGRRSIAGSLVGGIQ
HHHHEEHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ETQEMLDFAAEHGIEPKIEVIGADQVDEAYERILRSDVRYRFVIDISTL
HHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure
MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGICHSDIHSAFDEWGGGIF
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCC
PMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEYCLNAEEQFCTKGVVQTYN
CCCCCHHHHHHHHHHCCHHEEEECCCCCCCEEEECCCCCCHHHCCCHHHHHHHHHHHHHC
SVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLLCAGITTYSPLKHWNVGPGKK
CCCCCCCCCCCCCCCEEEEECEEEEECCCHHCHHHCCCHHHHCCCCCCCCCCCCCCCCCE
VAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEALELGANHYFATSDPATFTALAGR
EEEEEECCHHHHHHHHHHHCCCEEEEEHHHCCHHHHHHHHCCCCEEECCCCCHHHHHHHH
FDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKPDTYSVFSLIMGRRSIAGSLVGGIQ
HHHHEEHHHCCCCHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
ETQEMLDFAAEHGIEPKIEVIGADQVDEAYERILRSDVRYRFVIDISTL
HHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377