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The map label for this gene is trpC

Identifier: 255767488

GI number: 255767488

Start: 2374139

End: 2374888

Strand: Reverse

Name: trpC

Synonym: BSU22660

Alternate gene names: 255767488

Gene position: 2374888-2374139 (Counterclockwise)

Preceding gene: 50812260

Following gene: 255767487

Centisome position: 56.34

GC content: 42.27

Gene sequence:

>750_bases
ATGCTTGAAAAAATCATCAAACAAAAGAAAGAAGAAGTGAAAACACTGGTTCTGCCGGTAGAGCAGCCTTTCGAGAAACG
TTCATTTAAGGAGGCGCTGGCAAGCCCGAATCGGTTTATCGGGTTGATTGCCGAAGTGAAGAAAGCATCGCCGTCAAAAG
GGCTTATTAAAGAGGATTTTGTACCTGTGCAGATTGCAAAAGACTATGAGGCTGCGAAGGCAGATGCGATTTCCGTTTTA
ACAGACACCCCGTTTTTTCAAGGGGAAAACAGCTATTTATCAGACGTAAAGCGTGCTGTTTCGATTCCTGTACTTAGAAA
AGATTTTATTGATTCTCTTCAAGTAGAGGAATCAAGAAGAATCGGAGCGGATGCCATATTGTTAATCGGCGAGGTGCTTG
ATCCCTTACACCTTCATGAATTATATCTTGAAGCAGGTGAAAAGGGGATGGACGTGTTAGTGGAGGTTCATGATGCATCA
ACGCTAGAACAAATATTGAAAGTGTTCACACCCGACATTCTCGGCGTAAATAATCGAAACCTAAAAACGTTTGAAACATC
TGTAAAGCAGACAGAACAAATCGCATCTCTCGTTCCGAAAGAATCCTTGCTTGTCAGCGAAAGCGGAATCGGTTCTTTAG
AACATTTAACATTTGTCAATGAACATGGGGCGCGAGCTGTACTTATCGGTGAATCATTGATGAGACAAACTTCTCAGCGT
AAAGCAATCCATGCTTTGTTTAGGGAGTGA

Upstream 100 bases:

>100_bases
GCCTCACTGAAGGAAGGAACGGAGCTGGCGTTAGAGACGATTACAAGCGGAGGCGCTGCCGCGCAGCTTGAACGACTAAA
GCAGAAAGAGGAAGAGATCT

Downstream 100 bases:

>100_bases
GGTTGTGAAGAAACCGGCATTAAAATATTGCGGTATTCGGTCACTAAAGGATTTGCAGCTTGCGGCGGAATCACAGGCTG
ATTACCTAGGATTTATTTTT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIAEVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVL
TDTPFFQGENSYLSDVKRAVSIPVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS
TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTFVNEHGARAVLIGESLMRQTSQR
KAIHALFRE

Sequences:

>Translated_249_residues
MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIAEVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVL
TDTPFFQGENSYLSDVKRAVSIPVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS
TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTFVNEHGARAVLIGESLMRQTSQR
KAIHALFRE
>Mature_249_residues
MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIAEVKKASPSKGLIKEDFVPVQIAKDYEAAKADAISVL
TDTPFFQGENSYLSDVKRAVSIPVLRKDFIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDAS
TLEQILKVFTPDILGVNNRNLKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTFVNEHGARAVLIGESLMRQTSQR
KAIHALFRE

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=223, Percent_Identity=36.322869955157, Blast_Score=113, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6322638, Length=229, Percent_Identity=36.2445414847162, Blast_Score=122, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_BACSU (P03964)

Other databases:

- EMBL:   K01391
- EMBL:   AL009126
- PIR:   A01134
- RefSeq:   NP_390147.3
- ProteinModelPortal:   P03964
- SMR:   P03964
- EnsemblBacteria:   EBBACT00000002694
- GeneID:   939004
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU22660
- GenoList:   BSU22660
- GeneTree:   EBGT00050000001798
- HOGENOM:   HBG540956
- ProtClustDB:   PRK00278
- BioCyc:   BSUB:BSU22660-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 27741; Mature: 27741

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIAEVKKASPSKGLIKEDF
CHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHCC
VPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSIPVLRKDFIDSLQVEESRR
EEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
IGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDASTLEQILKVFTPDILGVNNRN
CCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
LKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTFVNEHGARAVLIGESLMRQTSQR
CHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCHHHHEEECCCCCEEEEECHHHHHHHHHH
KAIHALFRE
HHHHHHHCC
>Mature Secondary Structure
MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASPNRFIGLIAEVKKASPSKGLIKEDF
CHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHCC
VPVQIAKDYEAAKADAISVLTDTPFFQGENSYLSDVKRAVSIPVLRKDFIDSLQVEESRR
EEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
IGADAILLIGEVLDPLHLHELYLEAGEKGMDVLVEVHDASTLEQILKVFTPDILGVNNRN
CCHHHHHHHHHHHCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCC
LKTFETSVKQTEQIASLVPKESLLVSESGIGSLEHLTFVNEHGARAVLIGESLMRQTSQR
CHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCHHHHEEECCCCCEEEEECHHHHHHHHHH
KAIHALFRE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3924737; 9384377; 10568751; 6425119