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The map label for this gene is trpD

Identifier: 50812260

GI number: 50812260

Start: 2374881

End: 2375897

Strand: Reverse

Name: trpD

Synonym: BSU22670

Alternate gene names: 50812260

Gene position: 2375897-2374881 (Counterclockwise)

Preceding gene: 16079325

Following gene: 255767488

Centisome position: 56.36

GC content: 47.49

Gene sequence:

>1017_bases
ATGAACAGATTTCTACAATTGTGCGTTGACGGAAAAACCCTTACTGCCGGTGAGGCTGAAACGCTGATGAATATGATGAT
GGCAGCGGAAATGACTCCTTCTGAAATGGGGGGGATATTGTCAATTCTTGCTCATCGGGGGGAGACGCCAGAAGAGCTTG
CGGGTTTTGTGAAGGCAATGCGGGCACACGCTCTTACAGTCGATGGACTTCCTGATATTGTTGATACATGCGGAACAGGG
GGAGACGGTATTTCCACTTTTAATATCTCAACGGCCTCGGCAATTGTTGCCTCGGCAGCTGGTGCGAAAATCGCTAAGCA
TGGCAATCGCTCTGTCTCTTCTAAAAGCGGAAGCGCTGATGTTTTAGAGGAGCTAGAGGTTTCTATTCAAACCACTCCCG
AAAAGGTCAAAAGCAGCATTGAAACAAACAACATGGGATTTCTTTTTGCGCCGCTTTACCATTCGTCTATGAAACATGTA
GCAGGTACTAGAAAAGAGCTAGGTTTCAGAACGGTATTTAATCTGCTTGGGCCGCTCAGCAATCCTTTACAGGCGAAGCG
TCAGGTGATTGGGGTCTATTCTGTTGAAAAAGCTGGACTGATGGCAAGCGCACTGGAGACGTTTCAGCCGAAGCACGTTA
TGTTTGTATCAAGCCGTGACGGTTTAGATGAGCTTTCAATTACAGCACCGACCGACGTGATTGAATTAAAGGACGGAGAG
CGCCGGGAGTATACCGTTTCACCCGAAGATTTCGGTTTCACAAATGGCAGACTTGAAGATTTACAGGTGCAGTCTCCGAA
AGAGAGCGCTTATCTCATTCAGAATATTTTTGAAAATAAAAGCAGCAGTTCCGCTTTATCTATTACGGCTTTTAATGCGG
GTGCTGCGATTTACACGGCGGGAATTACCGCCTCACTGAAGGAAGGAACGGAGCTGGCGTTAGAGACGATTACAAGCGGA
GGCGCTGCCGCGCAGCTTGAACGACTAAAGCAGAAAGAGGAAGAGATCTATGCTTGA

Upstream 100 bases:

>100_bases
CCGGAAGCCGAATACGAAGAAAGCTGTAATAAAGCCGGTGCGCTGCTGAAAACGATTCATATTGCAGAAGACATGTTTCA
TAGCAAGGAGGATAAAGCTG

Downstream 100 bases:

>100_bases
AAAAATCATCAAACAAAAGAAAGAAGAAGTGAAAACACTGGTTCTGCCGGTAGAGCAGCCTTTCGAGAAACGTTCATTTA
AGGAGGCGCTGGCAAGCCCG

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTG
GDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV
AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGE
RREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSG
GAAAQLERLKQKEEEIYA

Sequences:

>Translated_338_residues
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTG
GDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV
AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGE
RREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSG
GAAAQLERLKQKEEEIYA
>Mature_338_residues
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTG
GDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV
AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGE
RREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSG
GAAAQLERLKQKEEEIYA

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=282, Percent_Identity=38.6524822695035, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320561, Length=275, Percent_Identity=34.1818181818182, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_BACSU (P03947)

Other databases:

- EMBL:   K01391
- EMBL:   M80245
- EMBL:   AL009126
- PIR:   A00586
- RefSeq:   NP_390148.2
- ProteinModelPortal:   P03947
- SMR:   P03947
- EnsemblBacteria:   EBBACT00000003454
- GeneID:   939007
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU22670
- GenoList:   BSU22670
- GeneTree:   EBGT00050000002544
- HOGENOM:   HBG559996
- OMA:   HGNKSAS
- PhylomeDB:   P03947
- ProtClustDB:   PRK00188
- BioCyc:   BSUB:BSU22670-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 36023; Mature: 36023

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAM
CCCCEEEEECCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSAD
HHHHEEECCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCHHHHHCCCCCCCCCCCCHH
VLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHVAGTRKELGFRTVFNLLGPLS
HHHHHHHHHCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
NPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGE
CHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCEEEECCCC
RREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTA
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEE
GITASLKEGTELALETITSGGAAAQLERLKQKEEEIYA
CCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILAHRGETPEELAGFVKAM
CCCCEEEEECCCEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGAKIAKHGNRSVSSKSGSAD
HHHHEEECCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCHHHHHCCCCCCCCCCCCHH
VLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHVAGTRKELGFRTVFNLLGPLS
HHHHHHHHHCCCHHHHHHHHCCCCCCEEEEHHHHHHHHHHHCHHHHHHHHHHHHHHCCCC
NPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSSRDGLDELSITAPTDVIELKDGE
CHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCEEEECCCC
RREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNIFENKSSSSALSITAFNAGAAIYTA
CCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEE
GITASLKEGTELALETITSGGAAAQLERLKQKEEEIYA
CCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3924737; 6425119; 9384377; 10568751