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The map label for this gene is hisC

Identifier: 255767486

GI number: 255767486

Start: 2370415

End: 2371497

Strand: Reverse

Name: hisC

Synonym: BSU22620

Alternate gene names: 255767486

Gene position: 2371497-2370415 (Counterclockwise)

Preceding gene: 16079320

Following gene: 16079318

Centisome position: 56.26

GC content: 45.15

Gene sequence:

>1083_bases
TTGCGTATCAAAGAACATTTAAAACAGCTGAAGCCTTATCAGCCTGGAAAGCCGATTGAAGCAGTGAAATCAGAATATGG
CTTGGATAAAGTTGTGAAGCTTGCTTCAAACGAGAATCCTTACGGCTGTTCAGAGGCTGCAAAAGAGGCGCTTCATCATG
AGATTCAACAGCTAGCCCTTTACCCGGACGGGTATAGCGCCGCTTTGCGGACAAGGCTCAGTAAGCACCTCAATGTCAGC
GAAACATCACTTATTTTCGGCAACGGTTCTGATGAAATCATACAGATCATCTGCCGGGCATTTTTAAACGATAAAACAAA
CACGGTTACTGCTGCCCCCACTTTTCCGCAATATAAACATAATGCGGTTATTGAAGGTGCTGAAGTACGTGAAATTGCAC
TTCGTCCCGACGGCTCACATGATTTAGACGCCATGTTAGAAGCCATCGACGAACAGACACAAGTCGTTTGGATATGCAGC
CCGAATAATCCGACTGGCACTTATACATCTGAAGGAGAATTACTCGCATTTCTGGAGCGCGTTCCTTCTCGTGTCCTTGT
CGTTCTTGACGAAGCATATTATGAATATGTAACAGCAGAGGATTACCCGGAAACCGTGCCGCTCTTAAGCAAGTATTCCA
ATTTGATGATTTTGCGCACATTTTCAAAGGCATACGGTCTGGCAGCGCTCAGAGTCGGATACGGAATTGCTGACGAGAAC
CTGATTCGCCAGATTGAGCCGGCGAGAGAGCCGTTTAATACCAGCCGTCTGGGCCAGGCTGCGGCGATTGCAGCACTTGA
TGATCAAGCGTTTATTGCTTCCTGTGTCGAGCAAAATAATGCAGGCCTTCAGCAGTATTATGATTTTGCGAAAACTCATG
GTTTAAAGTGCTACCCTTCACAGACAAATTTTGTGTTAATTGACTTTAAACGTCCTGCTGATGAACTGTTTCAGGCTCTG
CTGGAAAAAGGCTATATCGTCCGGTCAGGAAACGCATTAGGTTTCCCGACATCACTCCGGATTACGATCGGAACAAAAGA
GCAAAATGAAGAAATACTTGCCATTTTAGCTGAAATTTTATAA

Upstream 100 bases:

>100_bases
CGGCTCATCAGCGCTGAAACGAGAAATCAGGCGCTGCAGGAGTTTGAGGATTATGCAATGGCGTTTAGCGGCTTGTACAG
TTTAAAATGAGGTGACTGAT

Downstream 100 bases:

>100_bases
GAGGTGATCAAATATCACCTCTTTAGTCTATAAACCAGGTGATGACGTATGAATCAAATGAAAGATACAATATTGCTCGC
CGGTCTCGGATTGATAGGCG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVS
ETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS
PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADEN
LIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQAL
LEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL

Sequences:

>Translated_360_residues
MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVS
ETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS
PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADEN
LIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQAL
LEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL
>Mature_360_residues
MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVS
ETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS
PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADEN
LIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQAL
LEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=361, Percent_Identity=28.2548476454294, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322075, Length=367, Percent_Identity=29.700272479564, Blast_Score=120, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 40037; Mature: 40037

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLAL
CCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
YPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKH
CCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
NAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICSPNNPTGTYTSEGELLAFLER
CCEECCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
VPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADEN
CCHHEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCHH
LIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPS
HHHHHHHCCCCCCHHHCCHHHEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECC
QTNFVLIDFKRPADELFQALLEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCSEAAKEALHHEIQQLAL
CCHHHHHHHCCCCCCCCCHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHC
YPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFLNDKTNTVTAAPTFPQYKH
CCCCHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCC
NAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICSPNNPTGTYTSEGELLAFLER
CCEECCCCEEEEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHH
VPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMILRTFSKAYGLAALRVGYGIADEN
CCHHEEEEEHHHHHHHHCCCCCCCHHHHHHHHCCEEEEEEHHHHHHHHHHHHCCCCCCHH
LIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCVEQNNAGLQQYYDFAKTHGLKCYPS
HHHHHHHCCCCCCHHHCCHHHEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEECC
QTNFVLIDFKRPADELFQALLEKGYIVRSGNALGFPTSLRITIGTKEQNEEILAILAEIL
CCCEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCCCEEEEEECCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA