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The map label for this gene is yngE

Identifier: 255767426

GI number: 255767426

Start: 1949682

End: 1951217

Strand: Reverse

Name: yngE

Synonym: BSU18210

Alternate gene names: 255767426

Gene position: 1951217-1949682 (Counterclockwise)

Preceding gene: 16078883

Following gene: 16078881

Centisome position: 46.29

GC content: 47.85

Gene sequence:

>1536_bases
ATGCTGATGGATTATGAAAAGGAACGAACAGAACGGGCTGAACGGATTCGAAAAGGCGGAGCGGAAAAGTATCATCAAAG
CAATCGGGAAAAAGGCAAGCTCTTTGTCAGAGAGCGGCTTTCCCTTCTCTTTGACGATGACATTGAGCTAGAAGACGCTT
TTTTTGCGGAATGTATGTCAGACGGGCTTCCCGCTGACGGAGTTGTAACCGCTATCGGCAAAATCGGCGGCCAAACCGTT
TGCGTCATGGCGAATGATTCAACAGTGAAAGCGGGGTCATGGGGAGCAAAAACAGTTGAAAAAATCATCAGAATTCAAGA
AATCGCCGAAAAATTAAACTGTCCGCTCATTTATTTAGTCGATTCGGCAGGCGCCCGAATTACCGACCAAATCAATGTCT
TTCCAGGGAGACGCGGTGCAGGAAGAATTTTTTACAATCAAGTCAAATTATCGGGACGCATTCCGCAAATCTGTCTGCTT
TTCGGACCATCTGCGGCAGGAGGCGCTTATATTCCGGCCTTCTGTGATATCGTCGTTATGGTAGACGGTAACGCCTCCAT
GTATTTAGGTTCGCCAAGGATGGCGGAAATGGTTATTGGAGAAAAAGTGTCTCTCGAAGAAATGGGTGGCGCCCGTATGC
ATTGCTCAATCTCCGGCTGCGGAGATATTCTTGCAGAAACTGAAGAAGAAGCCATACAGCTGGTGCGGGCTTATTTGTCT
TACTTTCCGGCAAATTTTCAAGAAAAAGCGCCCATTCATGAGAAACGCCCGCCAAAACACTTCGAAACTCCGCTTGCCGA
CGTCATTCCGCAAAATCAAAACGCACCTTTTGATATGCATGAGCTCATTGAGCGGGTCATAGATGAAGACTCATTTTTTG
AGATCAAAGCCTTATTTGCACCGGAATTATTGACGGGCCTCGCACGAATCCACGGACAGCCTGTCGGCATTGTTGCAAAC
CAGCCGAAGGTAAAAGGAGGCGTCTTATTCCACGATTCAGCAGACAAAGCGGCTAAGTTTATTACCTTATGTGACGCTTT
TCATATCCCATTGCTGTTCTTAGCCGATATCCCCGGTTTTATGATTGGCACAAAAGTAGAACAGGCTGGGATTATCAGAC
ACGGAGCGAAAATGATTTCTGCGATGTCGGAGGCAACTGTTCCAAAACTCTCTGTCATTGTCCGAAAAGCTTACGGGGCG
GGGTTGTATGCAATGGCAGGGCCGGCATTTGAACCGGATTGCTGTCTAGCGCTCCCAACCGCCCAAATCGCCGTCATGGG
CCCTGAGGCCGCTGTAAACGCTGTCTACGCTAAAAAAATCGCCGAGCTGCCAGAAGAAGAGAGAGCCGCATTTATCAGCA
GCAAACGGGAGGAATACAAAGAGGACATCAATATCTACCGTCTGGCTTCAGAAATGATCATTGATGCTGTTATCCCAGCC
AATTCGCTGCGTGATGAGCTGGCCAAACGGCTCAAGGCATACATGACAAAGGAAATGACATTTACCAATCGAAAGCATCC
GGTTTATCCGGTGTAA

Upstream 100 bases:

>100_bases
GCGTATGAACAAACCATCCCGACAAAAGACAGGAGAGAAGGGCTTCAGGCCTTTCAAGAAAAAAGACGGGCCGTATACAA
GGGAATATAAAAGGGAGGCA

Downstream 100 bases:

>100_bases
AAGCAAGAACTTAGGAGCGCAAAAAAAGCGCTCCTTTATATATTTACAATAACAACATTATGTCAACTAATTACCATTGC
ATAAAACGCTTGGTTTTTTA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTV
CVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL
FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLS
YFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVAN
QPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGA
GLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPA
NSLRDELAKRLKAYMTKEMTFTNRKHPVYPV

Sequences:

>Translated_511_residues
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTV
CVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL
FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLS
YFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVAN
QPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGA
GLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPA
NSLRDELAKRLKAYMTKEMTFTNRKHPVYPV
>Mature_511_residues
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTV
CVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL
FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLS
YFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVAN
QPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGA
GLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPA
NSLRDELAKRLKAYMTKEMTFTNRKHPVYPV

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain

Homologues:

Organism=Homo sapiens, GI119943100, Length=516, Percent_Identity=37.015503875969, Blast_Score=315, Evalue=1e-85,
Organism=Homo sapiens, GI295821216, Length=536, Percent_Identity=35.8208955223881, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI11545863, Length=487, Percent_Identity=37.9876796714579, Blast_Score=296, Evalue=4e-80,
Organism=Homo sapiens, GI134142062, Length=342, Percent_Identity=24.5614035087719, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17552936, Length=498, Percent_Identity=34.3373493975904, Blast_Score=305, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI25147362, Length=510, Percent_Identity=35.4901960784314, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI25147359, Length=510, Percent_Identity=35.4901960784314, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI133931226, Length=311, Percent_Identity=24.4372990353698, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24586065, Length=516, Percent_Identity=36.6279069767442, Blast_Score=312, Evalue=4e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YNGE_BACSU (O31825)

Other databases:

- EMBL:   AL009126
- EMBL:   Y13917
- RefSeq:   NP_389703.2
- HSSP:   P96885
- ProteinModelPortal:   O31825
- SMR:   O31825
- EnsemblBacteria:   EBBACT00000003909
- GeneID:   939528
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU18210
- GenoList:   BSU18210
- GeneTree:   EBGT00050000000003
- HOGENOM:   HBG461319
- ProtClustDB:   CLSK872937
- BioCyc:   BSUB:BSU18210-MONOMER
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762

Pfam domain/function: PF01039 Carboxyl_trans

EC number: 6.4.1.3

Molecular weight: Translated: 56183; Mature: 56183

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS50989 COA_CT_CTER; PS50980 COA_CT_NTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMS
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLV
CCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVVM
CCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEE
VDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLS
ECCCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHH
YFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFA
HCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHH
PELLTGLARIHGQPVGIVANQPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGF
HHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCH
MIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCLALPT
HHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCC
AQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPA
CEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSLRDELAKRLKAYMTKEMTFTNRKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLFDDDIELEDAFFAECMS
CCCCCHHHHHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
DGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKIIRIQEIAEKLNCPLIYLV
CCCCCCHHHHHHHHCCCCEEEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEE
DSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLLFGPSAAGGAYIPAFCDIVVM
CCCCCEEEEEEEECCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEEE
VDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSISGCGDILAETEEEAIQLVRAYLS
ECCCCEEEECCCHHHHHHHCCCCCHHHCCCCEEEEEECCHHHHHHCCHHHHHHHHHHHHH
YFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAPFDMHELIERVIDEDSFFEIKALFA
HCCCCCCCCCCCCCCCCCCHHCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEHHHHHH
PELLTGLARIHGQPVGIVANQPKVKGGVLFHDSADKAAKFITLCDAFHIPLLFLADIPGF
HHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCH
MIGTKVEQAGIIRHGAKMISAMSEATVPKLSVIVRKAYGAGLYAMAGPAFEPDCCLALPT
HHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEECCC
AQIAVMGPEAAVNAVYAKKIAELPEEERAAFISSKREEYKEDINIYRLASEMIIDAVIPA
CEEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NSLRDELAKRLKAYMTKEMTFTNRKHPVYPV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222