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The map label for this gene is cheA

Identifier: 255767374

GI number: 255767374

Start: 1712815

End: 1714833

Strand: Direct

Name: cheA

Synonym: BSU16430

Alternate gene names: 255767374

Gene position: 1712815-1714833 (Clockwise)

Preceding gene: 255767373

Following gene: 16078707

Centisome position: 40.63

GC content: 41.95

Gene sequence:

>2019_bases
ATGGATATGAATCAGTATTTAGATGTCTTTATTGATGAGAGTAAAGAACATTTACAAACATGTAATGAAAAGCTTCTTCT
TTTAGAGAAAGACCCGACTGATCTTCAGCTCGTACATGATATATTCAGGGCTGCCCATACATTAAAAGGAATGAGCGCAA
CGATGGGCTACACGGATTTAGCACATCTTACCCATCTGCTTGAAAACGTGCTGGATGCAATCCGAAACGGAGACATGGAA
GTCACCTCAGACTGGCTGGATATTTTGTTTGAAGCTCTGGATCACCTGGAAACAATGGTTCAGTCTATTATTGATGGCGG
GGATGGTAAAAGAGATATCTCAGAAGTGAGTGCCAAGCTTGATGTGAATGGTGCGCACGCTGAATCCGCTGCCTCCGCTG
AACCTGCAGAAGCACAGAGTTCAGCATCTGATTGGGAATATGATGAATTTGAACGCACAGTTATACAAGAAGCGGAGGAG
CAAGGCTTCAAACGATATGAAATCAAGATTTCTCTGAACGAAAACTGTATGTTAAAAGCAGTTCGTGTCTATATGGTGTT
TGAAAAACTAAATGAAGTCGGAGAAGTAGCCAAAACAATTCCAAGTGCTGAAGTGCTTGAAACAGAAGATTTTGGAACTG
ACTTTCAAGTTTGTTTCTTAACACATCAATCAGCGGAAGACATTGAACAATTAATCAATGGCGTGTCGGAAATTGAGCAT
GTTGAAGTCATTCAAGGGGCTCCTTTAACATCAGCTGAAAAGCCTGAAGAATCTAAGCAAGAAGATTCACCAGCAGCAGC
TGTACCTGCGAAGCAGGAGAAACAAAAACAGCCTGCTAAAAACGATGAACAGGCGAAGCATTCAGCCGGCGGATCTAAAA
CAATTCGTGTCAACATTGACAGGCTTGATTCTTTAATGAACTTATTTGAAGAGCTTGTCATTGACCGCGGGCGTCTCGAG
CAGATTGCGAAAGAGCTTGAGCATAATGAACTGACTGAAACGGTTGAACGAATGACGAGAATTTCCGGAGATTTGCAATC
GATTATTCTGAATATGAGAATGGTCCCGGTTGAAACTGTTTTTAACAGATTCCCGAGAATGATTCGCCAGCTTCAGAAAG
AGCTGAATAAAAAAATTGAACTCTCGATCATCGGTGCGGAAACTGAACTGGATCGTACAGTAATTGATGAAATCGGAGAT
CCACTCGTTCACTTGATCAGAAACAGTATTGACCATGGTATCGAGGCGCCGGAAACACGTTTGCAAAAGGGAAAACCGGA
ATCAGGAAAAGTTGTGCTTAAAGCTTATCACAGCGGCAACCATGTCTTTATCGAAGTAGAGGATGACGGCGCAGGCCTTA
ATCGAAAAAAAATTCTGGAAAAAGCGCTTGAGCGCGGGGTCATAACGGAAAAAGAAGCTGAAACCTTAGAAGACAACCAA
ATTTACGAATTGATTTTTGCTCCGGGGTTCTCAACTGCTGACCAAATTTCTGATATTTCCGGCCGCGGTGTAGGACTTGA
CGTTGTAAAAAACAAACTGGAGTCTCTTGGCGGTTCAGTCAGTGTGAAATCAGCCGAGGGTCAAGGCTCTCTATTCAGCA
TCCAGCTGCCGCTTACCTTGTCTATTATTTCAGTTCTGCTGATTAAGTTGGAAGAAGAGACATTTGCCATTCCGATTTCT
TCAATCATTGAGACAGCAGTTATTGACAGAAAAGACATTTTGCAAACGCATGACCGTGAAGTGATTGACTTTAGAGGGCA
TATTGTCCCTGTCGTTTATTTAAAAGAAGAGTTTAAAATAGAAGATACAAGAAAAGATGCGGAACAGCTCCATATCATTG
TCGTGAAAAAAGGCGACAAACCTACTGCATTTGTGGTGGACTCCTTTATTGGCCAGCAGGAAGTTGTGCTGAAATCACTC
GGAGATTATTTAACAAACGTCTTTGCAATTTCCGGAGCTACTATTTTAGGAGACGGAGAAGTAGCGCTCATTATTGATTG
TAATGCACTGATTATTTAA

Upstream 100 bases:

>100_bases
AAGCTGCTGTTAAAGCGGGTCTCATTCATGAGATTAAACATGTGGAAGATATCGCAGCATCCATCACAAGCTGTGTGAAA
AAAGAGAGGGTGTGATTCAA

Downstream 100 bases:

>100_bases
CCATTCGAGGAGGTGTCTCACATGACTGCAGAAATTAAAACAGGCGAAAAAATGATAGTCTTTATGGTAAATGGCAAAGA
ATATGCCATTTCCGTCACTC

Product: chemotactic two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 672; Mature: 672

Protein sequence:

>672_residues
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDME
VTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE
QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEH
VEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLE
QIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGD
PLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQ
IYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPIS
SIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSL
GDYLTNVFAISGATILGDGEVALIIDCNALII

Sequences:

>Translated_672_residues
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDME
VTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE
QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEH
VEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLE
QIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGD
PLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQ
IYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPIS
SIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSL
GDYLTNVFAISGATILGDGEVALIIDCNALII
>Mature_672_residues
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDME
VTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE
QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEH
VEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLE
QIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGD
PLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQ
IYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPIS
SIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSL
GDYLTNVFAISGATILGDGEVALIIDCNALII

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain

Homologues:

Organism=Escherichia coli, GI1788197, Length=681, Percent_Identity=34.654919236417, Blast_Score=388, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CHEA_BACSU (P29072)

Other databases:

- EMBL:   M57894
- EMBL:   AL009126
- PIR:   A41653
- RefSeq:   NP_389525.2
- ProteinModelPortal:   P29072
- IntAct:   P29072
- EnsemblBacteria:   EBBACT00000001730
- GeneID:   939600
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU16430
- NMPDR:   fig|224308.1.peg.1646
- GenoList:   BSU16430
- GeneTree:   EBGT00050000002175
- HOGENOM:   HBG705053
- ProtClustDB:   CLSK873472
- BioCyc:   BSUB:BSU16430-MONOMER
- BRENDA:   2.7.13.3
- GO:   GO:0005737
- GO:   GO:0016020
- GO:   GO:0006935
- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:1.20.120.160
- Gene3D:   G3DSA:1.10.287.560
- PRINTS:   PR00344
- SMART:   SM00260
- SMART:   SM00387
- SMART:   SM00073

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2; SSF55874 ATP_bd_ATPase; SSF50341 CheW; SSF47384 His_kin_homodim; SSF47226 Hpt

EC number: =2.7.13.3

Molecular weight: Translated: 74813; Mature: 74813

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS50851 CHEW; PS50109 HIS_KIN; PS50894 HPT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDL
CCHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCHHHH
AHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKL
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEEQGFKRYEIKISLNENCMLKA
CCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHH
VRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEH
HHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
VEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNID
HHHHCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHCCCCCCEEEEEHH
RLDSLMNLFEELVIDRGRLEQIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
FNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGDPLVHLIRNSIDHGIEAPETR
HHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHH
LQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQ
HHCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCC
IYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTL
EEEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHH
SIISVLLIKLEEETFAIPISSIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKI
HHHHHHHHHCCCCCEECCHHHHHHHHHCCHHHHHHHCCCHHEECCCCEEEEEEECCHHCC
EDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGE
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEECCCC
VALIIDCNALII
EEEEEECCEEEC
>Mature Secondary Structure
MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRAAHTLKGMSATMGYTDL
CCHHHHHHHHHCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCHHHCCHHHH
AHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQSIIDGGDGKRDISEVSAKL
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHC
DVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEEQGFKRYEIKISLNENCMLKA
CCCCCCCCCCCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHH
VRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVCFLTHQSAEDIEQLINGVSEIEH
HHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHH
VEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQKQPAKNDEQAKHSAGGSKTIRVNID
HHHHCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHCCCCCCEEEEEHH
RLDSLMNLFEELVIDRGRLEQIAKELEHNELTETVERMTRISGDLQSIILNMRMVPVETV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
FNRFPRMIRQLQKELNKKIELSIIGAETELDRTVIDEIGDPLVHLIRNSIDHGIEAPETR
HHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHH
LQKGKPESGKVVLKAYHSGNHVFIEVEDDGAGLNRKKILEKALERGVITEKEAETLEDNQ
HHCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCCC
IYELIFAPGFSTADQISDISGRGVGLDVVKNKLESLGGSVSVKSAEGQGSLFSIQLPLTL
EEEEEEECCCCCHHHHHCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCEEEEECCHHH
SIISVLLIKLEEETFAIPISSIIETAVIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKI
HHHHHHHHHCCCCCEECCHHHHHHHHHCCHHHHHHHCCCHHEECCCCEEEEEEECCHHCC
EDTRKDAEQLHIIVVKKGDKPTAFVVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGE
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCEEECCCC
VALIIDCNALII
EEEEEECCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377