The gene/protein map for NC_000964 is currently unavailable.
Definition Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome.
Accession NC_000964
Length 4,215,606

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The map label for this gene is pyrC

Identifier: 255767363

GI number: 255767363

Start: 1621374

End: 1622660

Strand: Direct

Name: pyrC

Synonym: BSU15500

Alternate gene names: 255767363

Gene position: 1621374-1622660 (Clockwise)

Preceding gene: 255767362

Following gene: 16078615

Centisome position: 38.46

GC content: 46.39

Gene sequence:

>1287_bases
ATGTCATATCTCATTAAAAACGGCTGGATACTAAACGAAAATGGTGAAAAAACACAAGCGGATATCCGAGTGACTGGAGA
AACCATCACCGCAATCGGCAAGCTTGATGCAACGGATAATGAAACGGTAATTGATGCAAAAGGTTTGCTCGTTTCACCTG
GGTTTGTTGATCTCCACGTGCATTTCAGAGAGCCGGGCGGAGAGAAAAAAGAAACTATTGAAACCGGGGCAAAAGCAGCG
GCGCGCGGCGGCTATACTACAGTAGCAGCAATGCCGAATACGCGGCCGGTTCCTGATACAAAGGAGCAGATGGAATGGGT
GCAAAACAGAATTAAAGAAACATCATGCGTAAGAGTTCTTCCATATGCATCCATTACGATCAGACAAATCGGCGATGAAA
TGACAAACTTTGAAGCGTTAAAAGAAGCCGGGGCATTTGCTTTTACAGATGACGGCGTTGGTATACAGACAGCAGGAATG
ATGTATGAAGCGATGAAACGGGCAGCCGCAATTGACAAAGCGATTGTTGCACATTGCGAGGACAACTCCTTAATTTACGG
AGGGAGCGTACATGAGGGGACATTCTCCAAAGCGAACGGGCTAAACGGCATTCCTTCTGTGTGTGAATCGGTTCATATTG
CTCGCGATGTGCTGCTGGCTGAGGCGGCAAACTGCCATTATCATGTATGCCATATCAGCACAAAAGAATCTGTCAGAGTT
GTACGCGATGCGAAAAAAGCGGGAATCAGAGTGACAGCAGAAGTATCGCCGCATCATTTGCTGCTTTGTGATGAGGACAT
CCCGGGGCTGGACACAAACTATAAAATGAATCCTCCGCTCCGCAGCCCAGAAGACAGAGCTGCTTTAATTGAAGGTCTTT
TAGACGGAACAATTGATTTTATCGCAACAGACCATGCACCGCATACGGAAGAAGAGAAGAACACAGAAATGAAGCTGGCG
CCATTCGGAATTGTCGGCTTAGAAACAGCATTCCCGCTTCTTTACACACACTTTGTCAAAAATGGCAGCTGGTCACTGAA
GCAGCTGATTGACTACATGACAATCAAGCCATGCGAAGCGTTCGGTCTCCCATATGGAACATTACAAACGGGGCAAGCTG
CGGACATTACGTTAATCGATTTAGAAAAAGAAGCAGTTATAGACAAAGAGACATTTTTATCAAAAGGAAAAAATACACCA
TTCAACGGCATCAGTTGCACCGGCTGGCCGGTCGCTACAATTGCGGCAGGGAAGCTTGCTTATGAAGAGGGGAGACTTGT
CAAATGA

Upstream 100 bases:

>100_bases
AAATCAAGAATCTTCAAGCAAATGAAAAATGGCGTATTTATCAGAATGGCAGTGATACAGCGTGCCTTACAAACCAATGT
GAAAAGAGGAGAAGCAGCGT

Downstream 100 bases:

>100_bases
AGAGACGATTAGTACTGGAAAACGGAGCGGTATTCGAGGGAGAAGCTTTCGGAAGCTTAGAACACAACATGGGAGAAGTC
GTTTTTAATACTGGGATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAA
ARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM
MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRV
VRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLA
PFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTP
FNGISCTGWPVATIAAGKLAYEEGRLVK

Sequences:

>Translated_428_residues
MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAA
ARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM
MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRV
VRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLA
PFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTP
FNGISCTGWPVATIAAGKLAYEEGRLVK
>Mature_427_residues
SYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAA
RGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMM
YEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRVV
RDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAP
FGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPF
NGISCTGWPVATIAAGKLAYEEGRLVK

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI18105007, Length=417, Percent_Identity=31.1750599520384, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4503375, Length=453, Percent_Identity=24.5033112582781, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI19923821, Length=448, Percent_Identity=23.4375, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=23.568281938326, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=29.9319727891156, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI87082175, Length=448, Percent_Identity=25, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI193204318, Length=425, Percent_Identity=34.3529411764706, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71989490, Length=449, Percent_Identity=23.8307349665924, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539558, Length=450, Percent_Identity=23.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=22.3476297968397, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6322218, Length=391, Percent_Identity=28.3887468030691, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24642586, Length=403, Percent_Identity=29.7766749379653, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI18859883, Length=423, Percent_Identity=26.241134751773, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRC_BACSU (P25995)

Other databases:

- EMBL:   M59757
- EMBL:   AL009126
- PIR:   D39845
- RefSeq:   NP_389433.2
- ProteinModelPortal:   P25995
- SMR:   P25995
- MEROPS:   M38.972
- EnsemblBacteria:   EBBACT00000000984
- GeneID:   937095
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU15500
- NMPDR:   fig|224308.1.peg.1552
- GenoList:   BSU15500
- GeneTree:   EBGT00050000001626
- HOGENOM:   HBG724623
- ProtClustDB:   CLSK887279
- BioCyc:   BSUB:BSU15500-MONOMER
- BRENDA:   3.5.2.3
- HAMAP:   MF_00220_B
- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059
- TIGRFAMs:   TIGR00857

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.3

Molecular weight: Translated: 46533; Mature: 46402

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00482 DIHYDROOROTASE_1; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHV
CCEEEECCEEECCCCCCEEEEEEEECCEEEEEEECCCCCCCEEEECCCEEECCCEEEEEE
HFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVL
EEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
PYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMMYEAMKRAAAIDKAIVAHCE
CCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHEEEEC
DNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRV
CCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
VRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDF
HHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEA
EEECCCCCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
FGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLA
HCCCCCCCCCCCCCCEEEEECCHHHHHCHHHHHHCCCCCCCCCEEECCCCHHHHHHCCEE
YEEGRLVK
CCCCCCCC
>Mature Secondary Structure 
SYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVIDAKGLLVSPGFVDLHV
CEEEECCEEECCCCCCEEEEEEEECCEEEEEEECCCCCCCEEEECCCEEECCCEEEEEE
HFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKEQMEWVQNRIKETSCVRVL
EEECCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEE
PYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGMMYEAMKRAAAIDKAIVAHCE
CCCEEHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHEEEEC
DNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVLLAEAANCHYHVCHISTKESVRV
CCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHH
VRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKMNPPLRSPEDRAALIEGLLDGTIDF
HHHHHHCCEEEEEECCCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLLYTHFVKNGSWSLKQLIDYMTIKPCEA
EEECCCCCCCCCCCCCEEECCCCEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHH
FGLPYGTLQTGQAADITLIDLEKEAVIDKETFLSKGKNTPFNGISCTGWPVATIAAGKLA
HCCCCCCCCCCCCCCEEEEECCHHHHHCHHHHHHCCCCCCCCCEEECCCCHHHHHHCCEE
YEEGRLVK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1709162; 9384377