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The map label for this gene is ykcC

Identifier: 255767299

GI number: 255767299

Start: 1356447

End: 1357418

Strand: Direct

Name: ykcC

Synonym: BSU12890

Alternate gene names: 255767299

Gene position: 1356447-1357418 (Clockwise)

Preceding gene: 255767298

Following gene: 16078356

Centisome position: 32.18

GC content: 43.0

Gene sequence:

>972_bases
ATGAGCAGACATATTCAATATTCAATTGTTGTACCTGTGTATAATGAAGAGCTTGTCATTCATGAAACCTATCAGCGCTT
AAAAGAGGTCATGGATCAAACGAAGGAAAACTACGAGCTGCTTTTTGTCAACGATGGCAGCAAAGACCGCAGTATTGAGA
TTTTAAGAGAGCACAGCCTGATCGATCCGAGAGTGAAAATTATTGATTTTTCAAGGAATTTTGGACATCAGATCGCCATT
ACGGCAGGTATGGATTATGCACAGGGGAATGCAATCGTCGTCATTGACGCCGATTTGCAGGACCCTCCTGAACTGATTTT
AGAAATGATTGAAAAGTGGAAGGAAGGCTATGAAGTCGTGTACGCCGTACGGACTAAACGAAAAGGGGAAACCTTTTTCA
AAAAACAAACCGCGGCTATGTTTTACCGGCTTCTCAGCGGTATGACAGATATTGATATCCCGATTGATACGGGGGATTTT
CGCCTCATGGACAGAAAAGTCTGTGATGAAATGAAGAGATTAAAAGAAAAAAATCCATTTGTAAGAGGGCTAGTCAGCTG
GGTGGGTTTCAAACAGACAGCGGTCGAGTATGTACGTGATGAAAGGCTCGCCGGAGAAACAAAGTACCCGCTCAAGAAAA
TGCTGAAGCTGTCAATGGACGGCATCACGACATTTTCACATAAACCGCTGAAGCTGGCAAGCTATGCGGGGATTTTAATG
TCAGGTACTGGATTTCTGTATATGTTTATCGTGCTGTATCTGAAGCTATTCACAGACAGCACGATTACCGGCTGGTCATC
ACTTATTGTGATCCAGCTCCTGTTCAGCGGCATTGTCCTTCTGATTTTGGGCGTGATTGGCGAATATATCGGCAGAATCT
ACGATGAAGCCAAAGACAGGCCGCTTTACATCGTCCAAAAATCGTATGGAATTGAAAATAAAAGACTCTATAGAGACCAG
CATATGTCATAA

Upstream 100 bases:

>100_bases
GCAAGGCTTCAGGTGAAAACGGCAAAATGGGCGGACCTGGCGGAATGAATCAGTCAGCAACATTATACGAACTACATGCT
GATGAATAGGAGGCAAAAAC

Downstream 100 bases:

>100_bases
CCTCAAACCCCCTGTCCGTAATGGACAGGGGGTTTTTATGCTCTGAGCACGATCTAAAGCAAAAGATGCTGATAGATATA
TGGAAATTGGGTAAAGAAGA

Product: glycosyltransferase

Products: GDP; dolichyl D-mannosyl phosphate

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVNDGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAI
TAGMDYAQGNAIVVIDADLQDPPELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF
RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLSMDGITTFSHKPLKLASYAGILM
SGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFSGIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQ
HMS

Sequences:

>Translated_323_residues
MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVNDGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAI
TAGMDYAQGNAIVVIDADLQDPPELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF
RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLSMDGITTFSHKPLKLASYAGILM
SGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFSGIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQ
HMS
>Mature_322_residues
SRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVNDGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAIT
AGMDYAQGNAIVVIDADLQDPPELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDFR
LMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLSMDGITTFSHKPLKLASYAGILMS
GTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFSGIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQH
MS

Specific function: Involved In O Antigen Modification. Catalyzes The Transfer Of The Glucose Residue From Udp-Glucose To A Lipid Carrier (By Similarity). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family. GtrB subfamily

Homologues:

Organism=Homo sapiens, GI4503363, Length=181, Percent_Identity=28.1767955801105, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788692, Length=303, Percent_Identity=41.2541254125413, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1788588, Length=307, Percent_Identity=31.9218241042345, Blast_Score=163, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325441, Length=108, Percent_Identity=36.1111111111111, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24585265, Length=173, Percent_Identity=30.0578034682081, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): YKCC_BACSU (O34319)

Other databases:

- EMBL:   AJ002571
- EMBL:   AL009126
- PIR:   E69855
- RefSeq:   NP_389172.2
- ProteinModelPortal:   O34319
- EnsemblBacteria:   EBBACT00000002878
- GeneID:   936326
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU12890
- NMPDR:   fig|224308.1.peg.1291
- GenoList:   BSU12890
- GeneTree:   EBGT00050000000544
- HOGENOM:   HBG752660
- ProtClustDB:   CLSK887150
- BioCyc:   BSUB:BSU12890-MONOMER
- InterPro:   IPR001173

Pfam domain/function: PF00535 Glycos_transf_2

EC number: 2.4.1.83

Molecular weight: Translated: 37434; Mature: 37303

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc87ecec)-; HASH(0xe934a84)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVNDGSKDRSIEILREHSL
CCCEEEEEEEEEEECCCEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCC
IDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDPPELILEMIEKWKEGYEVV
CCCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEE
YAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDFRLMDRKVCDEMKRLKEKNPF
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCHH
VRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLSMDGITTFSHKPLKLASYAGILM
HHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
SGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFSGIVLLILGVIGEYIGRIYDEAKDR
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLYIVQKSYGIENKRLYRDQHMS
CEEEEEECCCCCHHHHHHHCCCH
>Mature Secondary Structure 
SRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVNDGSKDRSIEILREHSL
CCEEEEEEEEEEECCCEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHCCC
IDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDPPELILEMIEKWKEGYEVV
CCCCEEEEEECCCCCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCEEE
YAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDFRLMDRKVCDEMKRLKEKNPF
EEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCHH
VRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLSMDGITTFSHKPLKLASYAGILM
HHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHC
SGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFSGIVLLILGVIGEYIGRIYDEAKDR
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PLYIVQKSYGIENKRLYRDQHMS
CEEEEEECCCCCHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDPmannose; dolichyl phosphate

Specific reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377