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The map label for this gene is ntdC

Identifier: 255767240

GI number: 255767240

Start: 1126400

End: 1127452

Strand: Reverse

Name: ntdC

Synonym: BSU10530

Alternate gene names: 255767240

Gene position: 1127452-1126400 (Counterclockwise)

Preceding gene: 255767241

Following gene: 16078116

Centisome position: 26.74

GC content: 37.23

Gene sequence:

>1053_bases
ATGAAGAAGATAGGCATCATAGGTGCAGGTGGTATTGCAAGAGCGCATGCAACTGCTTTATCTACAATAAAAAATGCAGA
GTTAGTAGGGGTATATGACATAAATCAACAAAATGCGGAAAGCTTTGTGAAAACTTTCGGCGGGAAGTCATTTGAAAACG
TAGATGAACTAATTGATGCCTCAGAAGGTTTAATTGTAGCATCACCAAACTTTTGCCATAAAGAACATGCTTTGCAAGCA
TTAGGAAAACATAAGCATGTATTATGTGAAAAGCCTATGGCTATTTCTCTTGAAGAAGCAAGCATAATGAAAGATACTGC
TGAAAGGTTGAGCGTAAGAGCCAGTATGGGATTTAATTATAGATATTTATCTTACGTAAATATCTTAAAAAGCTTAATTA
TCAATAATGAACTAGGTAACATACTGTCCATAAAAGTACACTTCAAGAAAAATAGTGCACTTAGACGTAAGAAGTTTACT
TGGAGAGATGACGCTAATAGTAAGAAGACGAGTGGATCATTGGGGGATCTGGGTATTCACCTTATTGACATGGTATGGTA
TTTGTTCGAGAGTGATTTCATCACAGAATCAGTAAGGGCAAAGATGAACACAAATGTAAAAACAAAAGAGGATAAACAGG
TACTTGTAGATGACTATGCAGAAATTTATGGCCAGCTGAAGAACAAGGTATTTGTAAATATCATCACATCAAAGTGTTCT
GTACCTGAAGACTGTGGTTTTAGCATTGAGGTAGTTGGACACAAAAAAGAGTTTAAATACCACACAGGTAATCCTCACGT
TTACAAGCTCATAGATGGCTTGAACGTGGTAGACTGCCCAGTACCGCAAAGCCTATTAAACGATCCGCCAAACGAGTTTT
ATGGATGGGCTGATTCTTTTAGAAGCGAGTTAATCAATTGGATTGCATCAACTCAGAATGATTGGGTTGAGATCCCTTCT
TTTAGTGATGGTTTTAGATCTCAGGAAGTATTAGAAATGTTCTTTGAGAAAGACAGCAACTCTCAACCCATGTCTGTTTC
AGCAGTCAACTAG

Upstream 100 bases:

>100_bases
GAAGCCAAAAACTTGCACAACCTTATAACTGATAGTGAGTACTCAAAAGGAATTACTAATACCTTAAAAAAATTAATTGG
ATCATGAGGAGGAAATAAAA

Downstream 100 bases:

>100_bases
TATTTCAAAGAGAGAAGTTACTAAAAAAGCAGGAATTTACTTTCCTGCTTTTTCATATAGGGGTGTAATGAATGTTAAGA
GGGACATATTTATTTGGATA

Product: neotrehalosadiamine biosyntehsis dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDASEGLIVASPNFCHKEHALQA
LGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT
WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCS
VPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPS
FSDGFRSQEVLEMFFEKDSNSQPMSVSAVN

Sequences:

>Translated_350_residues
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDASEGLIVASPNFCHKEHALQA
LGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT
WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCS
VPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPS
FSDGFRSQEVLEMFFEKDSNSQPMSVSAVN
>Mature_350_residues
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDASEGLIVASPNFCHKEHALQA
LGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT
WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCS
VPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPS
FSDGFRSQEVLEMFFEKDSNSQPMSVSAVN

Specific function: Part of the ntdABC operon that biosynthesizes the NTD (3,3'-neotrehalosadiamine) antibiotic

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family

Homologues:

Organism=Escherichia coli, GI1787574, Length=193, Percent_Identity=32.6424870466321, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI87082405, Length=192, Percent_Identity=28.6458333333333, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTDC_BACSU (O07564)

Other databases:

- EMBL:   Y14081
- EMBL:   AL009126
- PIR:   A69834
- RefSeq:   NP_388934.2
- ProteinModelPortal:   O07564
- SMR:   O07564
- EnsemblBacteria:   EBBACT00000002713
- GeneID:   936337
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU10530
- NMPDR:   fig|224308.1.peg.1053
- GenoList:   BSU10530
- GeneTree:   EBGT00050000000829
- HOGENOM:   HBG338975
- ProtClustDB:   CLSK887019
- BioCyc:   BSUB:BSU10530-MONOMER
- GO:   GO:0005488
- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104
- Gene3D:   G3DSA:3.40.50.720

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C

EC number: 1.-.-.- [C]

Molecular weight: Translated: 39273; Mature: 39273

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDA
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCC
SEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNY
CCCEEEECCCCHHHHHHHHHHCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCC
RYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFTWRDDANSKKTSGSLGDLGIH
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
VPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSF
CCCCCCCEEEEEECCCCCCEECCCCEEEEEECCCCEECCCCCHHHHCCCCHHHHHHHHHH
RSELINWIASTQNDWVEIPSFSDGFRSQEVLEMFFEKDSNSQPMSVSAVN
HHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECC
>Mature Secondary Structure
MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVKTFGGKSFENVDELIDA
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHCC
SEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASIMKDTAERLSVRASMGFNY
CCCEEEECCCCHHHHHHHHHHCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCCC
RYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFTWRDDANSKKTSGSLGDLGIH
HHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDDYAEIYGQLKNKVFVNIITSKCS
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEECCCC
VPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNVVDCPVPQSLLNDPPNEFYGWADSF
CCCCCCCEEEEEECCCCCCEECCCCEEEEEECCCCEECCCCCHHHHCCCCHHHHHHHHHH
RSELINWIASTQNDWVEIPSFSDGFRSQEVLEMFFEKDSNSQPMSVSAVN
HHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377