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The map label for this gene is hutH

Identifier: 16080986

GI number: 16080986

Start: 4042051

End: 4043577

Strand: Direct

Name: hutH

Synonym: BSU39350

Alternate gene names: 16080986

Gene position: 4042051-4043577 (Clockwise)

Preceding gene: 16080985

Following gene: 16080987

Centisome position: 95.88

GC content: 49.51

Gene sequence:

>1527_bases
ATGGTGACTTTAGACGGTTCTTCATTGACAACAGCCGACGTCGCTCGTGTGCTGTTTGATTTTGAGGAGGCAGCGGCTTC
TGAGGAAAGTATGGAGCGCGTGAAAAAAAGCAGAGCAGCAGTGGAACGGATTGTACGCGACGAAAAGACAATCTACGGCA
TCAACACCGGATTTGGCAAATTCAGCGATGTCCTGATTCAGAAAGAAGACTCGGCGGCGCTGCAGCTGAATTTAATCCTT
TCTCATGCCTGCGGAGTCGGCGACCCTTTTCCTGAGTGTGTTTCCAGGGCAATGCTGCTTTTGCGCGCCAATGCGCTGTT
AAAAGGCTTTTCCGGTGTACGCGCTGAGCTGATCGAGCAGTTGCTTGCTTTTTTAAATAAACGCGTCCATCCTGTCATCC
CTCAGCAAGGATCACTTGGCGCAAGCGGAGATCTGGCGCCGCTTTCCCACTTGGCGCTTGCGCTGATCGGACAAGGAGAA
GTCTTTTTTGAGGGGGAAAGAATGCCGGCAATGACAGGCTTGAAAAAAGCAGGTATTCAACCGGTAACGCTGACATCCAA
GGAAGGGCTTGCCTTGATTAACGGGACTCAGGCCATGACTGCAATGGGGGTGGTCGCCTACATCGAAGCTGAGAAACTAG
CCTATCAAACAGAACGAATTGCCAGCTTAACGATTGAGGGGTTGCAGGGAATTATCGATGCATTTGACGAGGATATTCAC
TTAGCCCGCGGCTATCAGGAGCAGATCGATGTCGCAGAACGAATTCGCTTTTATCTATCTGACAGCGGCCTGACAACCTC
CCAGGGAGAACTGCGGGTACAGGATGCCTATTCATTGCGCTGTATTCCGCAAGTACACGGTGCGACTTGGCAGACACTAG
GATATGTCAAAGAAAAATTAGAGATTGAAATGAACGCAGCTACAGACAATCCACTCATTTTCAATGACGGTGACAAAGTG
ATTTCCGGCGGAAACTTTCACGGACAGCCAATCGCCTTTGCCATGGATTTTCTGAAAATCGCAATATCAGAGCTTGCGAA
TATCGCAGAGCGTAGGATCGAACGACTTGTGAATCCGCAGCTGAATGACCTGCCGCCGTTCCTGAGCCCTCATCCCGGTC
TGCAATCCGGTGCAATGATCATGCAGTACGCCGCGGCCTCACTCGTTTCTGAAAATAAAACACTGGCCCATCCTGCAAGT
GTGGATTCCATTCCGTCATCCGCCAACCAAGAGGACCATGTCAGCATGGGAACCATCGCCGCTCGGCATGCTTATCAGGT
GATCGCAAATACAAGGAGAGTCATTGCGATCGAAGCCATTTGCGCATTGCAGGCTGTTGAATACAGAGGCATAGAACATG
CAGCGTCCTATACGAAACAGCTTTTTCAAGAAATGAGAAAAGTCGTGCCGTCCATTCAGCAGGACCGTGTTTTTTCCTAT
GACATTGAACGCTTGACTGACTGGCTGAAGAAAGAATCTTTAATACCTGATCATCAGAATAAAGAACTAAGGGGGATGAA
CATATGA

Upstream 100 bases:

>100_bases
ATCTTAGACGATAGGGGGCTATGCGTGAAAACAGAAGTTCACAGCATAGCTCCTTTTTGTATGGGCGCTTTACCAAAGTA
AAGAAAAAGGAGTTGGGCTT

Downstream 100 bases:

>100_bases
CTGATGTAAAAAAATCAATCCGTGCCAACAGAGGAACAGAGCTTGAATGCTTAGGATGGGAGCAAGAGGCAGTGCTTCGG
ATGCTTCGAAACAACCTTGA

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERIVRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLIL
SHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE
VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDAFDEDIH
LARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDAYSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKV
ISGGNFHGQPIAFAMDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRGIEHAASYTKQLFQEMRKVVPSIQQDRVFSY
DIERLTDWLKKESLIPDHQNKELRGMNI

Sequences:

>Translated_508_residues
MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERIVRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLIL
SHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE
VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDAFDEDIH
LARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDAYSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKV
ISGGNFHGQPIAFAMDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRGIEHAASYTKQLFQEMRKVVPSIQQDRVFSY
DIERLTDWLKKESLIPDHQNKELRGMNI
>Mature_508_residues
MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERIVRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLIL
SHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE
VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDAFDEDIH
LARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDAYSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKV
ISGGNFHGQPIAFAMDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSENKTLAHPAS
VDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRGIEHAASYTKQLFQEMRKVVPSIQQDRVFSY
DIERLTDWLKKESLIPDHQNKELRGMNI

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=44.4672131147541, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17567831, Length=507, Percent_Identity=43.9842209072978, Blast_Score=396, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_BACSU (P10944)

Other databases:

- EMBL:   M20659
- EMBL:   D31856
- EMBL:   AL009126
- PIR:   S18810
- RefSeq:   NP_391814.1
- ProteinModelPortal:   P10944
- SMR:   P10944
- EnsemblBacteria:   EBBACT00000002434
- GeneID:   937541
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU39350
- NMPDR:   fig|224308.1.peg.3940
- GenoList:   BSU39350
- GeneTree:   EBGT00050000001273
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- ProtClustDB:   PRK09367
- BioCyc:   BSUB:BSU39350-MONOMER
- BioCyc:   MetaCyc:MONOMER-11609
- BRENDA:   4.3.1.3
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55675; Mature: 55675

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERIVRDEKTIYGINTGFGK
CEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
FSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELIEQ
HHHHHEECCCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGEVFFEGERMPAMTGLKKAGIQ
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCC
PVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDAFDEDIH
CEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDAYSLRCIPQVHGATWQTLGYVKEKL
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECHHCCCHHHHHHHHHHHH
EIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFAMDFLKIAISELANIAERRIERLVNPQ
EEEEECCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LNDLPPFLSPHPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARHAYQVIANTRRVIAIEAICALQAVEYRGIEHAASYTKQLFQEMRKVVPSIQQDRVFSY
HHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHH
DIERLTDWLKKESLIPDHQNKELRGMNI
HHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERIVRDEKTIYGINTGFGK
CEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
FSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLRANALLKGFSGVRAELIEQ
HHHHHEECCCCCEEEEHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGEVFFEGERMPAMTGLKKAGIQ
HHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHCCCC
PVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTERIASLTIEGLQGIIDAFDEDIH
CEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDAYSLRCIPQVHGATWQTLGYVKEKL
HHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCEEEECHHCCCHHHHHHHHHHHH
EIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFAMDFLKIAISELANIAERRIERLVNPQ
EEEEECCCCCCEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LNDLPPFLSPHPGLQSGAMIMQYAAASLVSENKTLAHPASVDSIPSSANQEDHVSMGTIA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
ARHAYQVIANTRRVIAIEAICALQAVEYRGIEHAASYTKQLFQEMRKVVPSIQQDRVFSY
HHHHHHHHHCCCCEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHCCHHHH
DIERLTDWLKKESLIPDHQNKELRGMNI
HHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454913; 7704263; 9384377