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The map label for this gene is menA

Identifier: 16080900

GI number: 16080900

Start: 3950726

End: 3951661

Strand: Reverse

Name: menA

Synonym: BSU38490

Alternate gene names: 16080900

Gene position: 3951661-3950726 (Counterclockwise)

Preceding gene: 16080907

Following gene: 16080899

Centisome position: 93.74

GC content: 47.54

Gene sequence:

>936_bases
ATGAACCAAACAAATAAGGGTGAGGGTCAGACAGCGCCGCAAAAAGAAAGCATGGGGCAGATCCTTTGGCAGTTAACCCG
TCCTCATACGTTAACCGCATCGTTTGTGCCTGTGCTGCTCGGAACCGTTTTGGCGATGTTTTATGTGAAGGTTGATCTGC
TGCTGTTTTTGGCTATGCTGTTTTCTTGCCTATGGATCCAGATCGCGACGAACTTATTTAATGAATACTATGATTTTAAA
CGCGGATTAGATACAGCAGAATCAGTCGGAATCGGAGGGGCCATTGTACGCCACGGAATGAAGCCTAAAACGATTTTGCA
ATTAGCTCTTGCCTCATACGGGATTGCCATTTTGCTCGGTGTCTATATTTGTGCCAGCAGCAGCTGGTGGCTTGCGCTGA
TCGGCCTTGTCGGCATGGCGATCGGCTACCTGTATACAGGCGGGCCGCTGCCGATTGCGTACACGCCGTTCGGTGAATTA
TTCTCAGGCATTTGCATGGGTTCGGTGTTTGTGCTGATTTCGTTTTTCATTCAGACAGATAAGATCAATATGCAGAGCAT
TTTGATTTCCATCCCGATTGCGATTCTTGTCGGCGCGATTAACCTGTCGAACAACATTCGTGATATTGAAGAGGACAAAA
AAGGCGGACGCAAAACATTGGCGATTTTGATGGGGCATAAGGGAGCTGTTACTCTGTTAGCTGCGTCGTTTGCCGTCGCT
TATATCTGGGTTGTCGGCTTGGTTATTACCGGTGCCGCAAGCCCATGGCTGTTTGTCGTCTTTTTGAGCGTGCCTAAGCC
GGTTCAGGCAGTGAAGGGCTTCGTCCAGAACGAAATGCCGATGAATATGATTGTCGCAATGAAATCAACAGCCCAAACAA
ATACATTTTTCGGATTCCTGCTCTCGATCGGATTATTGATCAGCTATTTCCGATAA

Upstream 100 bases:

>100_bases
TAAGGGAGAAGTCATTATGATAGATAAGGAAGCAAAAGGAGTTTTTTATTAAGCTGCCGGCTGAAAAAAAGTAAGCCTTT
TAATAGAAAGGAAGAGGAAG

Downstream 100 bases:

>100_bases
TAAAAAAGACCGCTCGTTTCATGCGGTCTTTTTTTGTTACAATCGACCGCATTTTGTAAAAAAATTCATAGAACCTTGCA
GCAGACAGGGACGTCTAGTA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFK
RGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL
FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVA
YIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR

Sequences:

>Translated_311_residues
MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFK
RGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL
FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVA
YIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR
>Mature_311_residues
MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFK
RGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL
FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVA
YIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family

Homologues:

Organism=Homo sapiens, GI7019551, Length=234, Percent_Identity=30.3418803418803, Blast_Score=98, Evalue=9e-21,
Organism=Escherichia coli, GI1790365, Length=305, Percent_Identity=25.5737704918033, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI17737429, Length=292, Percent_Identity=30.8219178082192, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MENA_BACSU (P39582)

Other databases:

- EMBL:   X73124
- EMBL:   AL009126
- PIR:   S39661
- RefSeq:   NP_391728.1
- ProteinModelPortal:   P39582
- EnsemblBacteria:   EBBACT00000001245
- GeneID:   937356
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU38490
- NMPDR:   fig|224308.1.peg.3854
- GenoList:   BSU38490
- GeneTree:   EBGT00050000002907
- HOGENOM:   HBG313998
- OMA:   NDYGDAI
- PhylomeDB:   P39582
- ProtClustDB:   PRK06080
- BioCyc:   BSUB:BSU38490-MONOMER
- BioCyc:   MetaCyc:MONOMER-13813
- InterPro:   IPR004657
- InterPro:   IPR000537
- TIGRFAMs:   TIGR00751

Pfam domain/function: PF01040 UbiA

EC number: =2.5.1.74

Molecular weight: Translated: 33839; Mature: 33839

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1286909c)-; HASH(0x121336fc)-; HASH(0x13387d68)-; HASH(0x134d84e8)-; HASH(0x13337094)-; HASH(0x1335232c)-; HASH(0x12db1374)-; HASH(0x12e8c5ec)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAML
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGELFSGICMGSVFVLISFFIQTD
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHC
KINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVA
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHH
YIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHEEECCCCHHHHHHHHH
LSIGLLISYFR
HHHHHHHHHCH
>Mature Secondary Structure
MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVLAMFYVKVDLLLFLAML
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKPKTILQLALASYGIAILLG
HHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGELFSGICMGSVFVLISFFIQTD
HHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHC
KINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRKTLAILMGHKGAVTLLAASFAVA
CCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHEEEEEECCCCHHHHHHHHHHHH
YIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQNEMPMNMIVAMKSTAQTNTFFGFL
HHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHEEECCCCHHHHHHHHH
LSIGLLISYFR
HHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377