Click here to switch to the map view.

The map label for this gene is ung

Identifier: 16080848

GI number: 16080848

Start: 3897685

End: 3898362

Strand: Reverse

Name: ung

Synonym: BSU37970

Alternate gene names: 16080848

Gene position: 3898362-3897685 (Counterclockwise)

Preceding gene: 16080849

Following gene: 255767800

Centisome position: 92.47

GC content: 48.53

Gene sequence:

>678_bases
TTGAAACAGCTTTTACAAGACAGCTGGTGGAATCAGCTAAAGGAAGAGTTTGAGAAACCGTATTATCAAGAGCTCAGAGA
GATGCTGAAGAGGGAATACGCGGAGCAAACGATTTATCCGGACAGCCGGGATATTTTCAACGCGCTGCATTATACATCAT
ATGATGATGTCAAGGTCGTCATTTTGGGTCAAGATCCGTATCACGGGCCGGGACAGGCTCAAGGTTTAAGCTTCTCTGTC
AAGCCCGGTGTAAAGCAGCCGCCTTCGTTAAAAAATATCTTTCTTGAGCTGCAGCAGGACATCGGGTGCAGCATCCCGAA
TCACGGGTCGCTTGTGAGCTGGGCAAAGCAAGGCGTTCTTTTGCTGAATACTGTGCTGACAGTAAGGCGCGGACAGGCGA
ATTCCCATAAGGGAAAAGGCTGGGAGCGACTGACGGACCGAATTATTGACGTGCTGAGTGAAAGAGAGCGGCCGGTTATC
TTTATTTTGTGGGGACGGCATGCTCAAATGAAAAAAGAACGGATCGACACCTCCAAGCATTTTATCATTGAATCGACGCA
TCCCAGCCCGTTTTCTGCGAGAAACGGATTTTTCGGGAGCAGACCGTTTTCCCGGGCGAATGCCTATTTGGAGAAAATGG
GAGAGGCGCCGATTGATTGGTGTATTAAGGATTTGTAA

Upstream 100 bases:

>100_bases
GAAGAGCCTGAGATGAAGAGGCGGGAAGCAAAAAGTGAAATGGTTTGGGATGGCGAGCCTGTCTATTCCAGACTTCATCG
TTCGTAAGGAGGCCTGAATC

Downstream 100 bases:

>100_bases
AAAGCGCAGGTGATCTGCGCTTTTTTATTTGAGTATTTTTCGAATCATTCGCAGCCCGTTTTTGGAGGAAGGATAACGAA
ATGCGAAGTCGAAACGGTTC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSV
KPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI
FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL

Sequences:

>Translated_225_residues
MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSV
KPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI
FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL
>Mature_225_residues
MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSV
KPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI
FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=50.2325581395349, Blast_Score=220, Evalue=9e-58,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=50.2325581395349, Blast_Score=220, Evalue=9e-58,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=53.4883720930233, Blast_Score=241, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17556304, Length=225, Percent_Identity=46.6666666666667, Blast_Score=211, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=237, Percent_Identity=42.6160337552743, Blast_Score=192, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_BACSU (P39615)

Other databases:

- EMBL:   X73124
- EMBL:   AL009126
- PIR:   S39712
- RefSeq:   NP_391676.1
- ProteinModelPortal:   P39615
- SMR:   P39615
- EnsemblBacteria:   EBBACT00000002582
- GeneID:   937265
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU37970
- NMPDR:   fig|224308.1.peg.3802
- GenoList:   BSU37970
- GeneTree:   EBGT00050000000847
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   P39615
- ProtClustDB:   PRK05254
- BioCyc:   BSUB:BSU37970-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 26047; Mature: 26047

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 65-65

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEE
ILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHH
LLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVIFILWGRHAQMKKERIDTSKH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCE
FIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCC
>Mature Secondary Structure
MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRDIFNALHYTSYDDVKVV
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEE
ILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIGCSIPNHGSLVSWAKQGVL
EECCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCHH
LLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVIFILWGRHAQMKKERIDTSKH
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCE
FIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPIDWCIKDL
EEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7934828; 9384377