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The map label for this gene is acdA

Identifier: 16080770

GI number: 16080770

Start: 3813246

End: 3814385

Strand: Reverse

Name: acdA

Synonym: BSU37170

Alternate gene names: 16080770

Gene position: 3814385-3813246 (Counterclockwise)

Preceding gene: 16080771

Following gene: 16080769

Centisome position: 90.48

GC content: 48.95

Gene sequence:

>1140_bases
ATGAATTTTTCATTATCAGAAGAACATGAGATGATACGAAAATTGGTGCGCGATTTTGCGAAGCATGAGGTGGCCCCGAC
AGCGGCTGAACGGGACGAACAAGAACGCTTCGATCGCGAGCTGTTTCGGGAAATGGCAAATCTGGGCCTGACGGGAATTC
CATGGCCTGAAGATTACGGCGGAATTGGAAGTGACTATTTAGCCTACGTCATCGCGGTGGAAGAGCTGTCAAAAGTGTGC
GCCTCCACCGGTGTGACGCTTTCCGCCCATATCTCTCTTTGCAGCTGGCCGCTGTTTGCCTTTGGGACAGAGGAACAGAA
GACAGAGTACTTAACACAGCTGGCTCTCGGAGAGAAAATCGGCGCATTCGCTTTGACCGAAGCAGGGTCTGGCTCTGACG
CCGGCAGCATGAAAACAACTGCTGAACGAATCGGCGATGACTATGTGTTAAATGGTTCCAAAGTGTTTATCACAAACGGC
GGCGTTGCTGATATTTACATTGTTTTTGCCGTCACCGATCCCGAGAAAAAGAAAAAAGGCGTTACCGCTTTTATAGTAGA
AAAGGATTTTGAAGGATTTTTTACAGGCAAGAAAGAAAAGAAGCTGGGCATCCGTTCTTCACCGACAACGGAAATCATGT
TCGAAGATTGTGTAGTGCCCGCATCAAAGCGTCTCGGAGAAGAAGGAGAAGGCTTCAAAATCGCGATGAAGACGCTTGAC
GGAGGCAGAAACGGCATAGCTGCACAAGCTGTAGGCATCGCCCAAGGAGCGCTTGATGCGGCGCTTCAATATGCAAAAGA
GCGAAAGCAATTCGGAAAATCGATCGCCGAGCAGCAGGGCATCGCTTTTAAACTCGCGGATATGGCGACAATGATAGAAG
CTTCAAGGCTACTGACCTATCAGGCTGCATGGTTAGAATCATCGGGCCTTCCATATGGAAAAGCTTCCGCCATGTCCAAA
CTGATGGCTGGGGATACGGCGATGAAGGTAACGACCGAAGCCGTGCAGATTTTCGGCGGCTACGGCTATACAAAAGATTA
TCCGGTAGAACGCTATATGCGTGATGCAAAAATCACGCAAATCTATGAAGGCACTCAAGAAATTCAAAGACTGGTCATCT
CCAGAATGCTCGCGGATTAA

Upstream 100 bases:

>100_bases
CAAAGGCGAAGGAAGCCGAAGACCAAGTCAAAACGTACGACGTCGTCGAGCTTCTGGCTCAATCCGTTTTAGGCGCTGAT
CTGAAAATGGGGGAGAAGCA

Downstream 100 bases:

>100_bases
CGGAAAACATCTCTCAGTCGGATCACTCTTGTAAAATTATTTAAATTAACGCTGTTAAGGGTAGCATATTCTGTTTTATT
TTGTTTATAATGAGAGGTAT

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVC
ASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG
GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLD
GGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSK
LMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD

Sequences:

>Translated_379_residues
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVC
ASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG
GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLD
GGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSK
LMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD
>Mature_379_residues
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVC
ASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG
GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLD
GGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSK
LMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD

Specific function: Involved in the degradation of long-chain fatty acids

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family

Homologues:

Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=50.9383378016086, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=43.3155080213904, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI7656849, Length=374, Percent_Identity=41.9786096256684, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=41.8848167539267, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=41.8848167539267, Blast_Score=289, Evalue=2e-78,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=41.8666666666667, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI226958414, Length=345, Percent_Identity=42.3188405797101, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI21361497, Length=351, Percent_Identity=42.7350427350427, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI4501857, Length=374, Percent_Identity=36.3636363636364, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI76496475, Length=377, Percent_Identity=38.7267904509284, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4557235, Length=377, Percent_Identity=38.7267904509284, Blast_Score=240, Evalue=1e-63,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=31.758530183727, Blast_Score=182, Evalue=3e-46,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=31.6216216216216, Blast_Score=171, Evalue=9e-43,
Organism=Homo sapiens, GI211971008, Length=322, Percent_Identity=29.5031055900621, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI48976061, Length=322, Percent_Identity=29.5031055900621, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI38505218, Length=291, Percent_Identity=29.2096219931272, Blast_Score=104, Evalue=2e-22,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=33.8541666666667, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1786223, Length=376, Percent_Identity=29.5212765957447, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI87081702, Length=311, Percent_Identity=28.2958199356913, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=27.3062730627306, Blast_Score=85, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=43.1635388739946, Blast_Score=310, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=45.6692913385827, Blast_Score=306, Evalue=9e-84,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=42.6315789473684, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17506239, Length=375, Percent_Identity=39.4666666666667, Blast_Score=293, Evalue=8e-80,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=41.1140583554377, Blast_Score=290, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=44.6194225721785, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17533517, Length=375, Percent_Identity=42.1333333333333, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI71990804, Length=275, Percent_Identity=46.5454545454545, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=37.3937677053824, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=38.4615384615385, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=32, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=41.7391304347826, Blast_Score=194, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=31.5508021390374, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17505929, Length=374, Percent_Identity=31.0160427807487, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71985192, Length=280, Percent_Identity=38.9285714285714, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17531909, Length=243, Percent_Identity=33.7448559670782, Blast_Score=157, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI17562446, Length=319, Percent_Identity=27.5862068965517, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17531913, Length=195, Percent_Identity=28.7179487179487, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI86563383, Length=309, Percent_Identity=27.831715210356, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI86563381, Length=309, Percent_Identity=27.831715210356, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=51.4824797843666, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24646207, Length=371, Percent_Identity=47.1698113207547, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=44.0633245382586, Blast_Score=302, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24666513, Length=373, Percent_Identity=40.7506702412869, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=42.4802110817942, Blast_Score=276, Evalue=2e-74,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=38.1201044386423, Blast_Score=242, Evalue=3e-64,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=31.5649867374005, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDA_BACSU (P45867)

Other databases:

- EMBL:   Z49782
- EMBL:   AL009126
- PIR:   S55421
- RefSeq:   NP_391598.1
- ProteinModelPortal:   P45867
- SMR:   P45867
- EnsemblBacteria:   EBBACT00000000554
- GeneID:   938457
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU37170
- NMPDR:   fig|224308.1.peg.3724
- GenoList:   BSU37170
- GeneTree:   EBGT00070000031843
- HOGENOM:   HBG699365
- OMA:   ALFDQMA
- PhylomeDB:   P45867
- ProtClustDB:   CLSK2752542
- BioCyc:   BSUB:BSU37170-MONOMER
- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100
- Gene3D:   G3DSA:2.40.110.10
- Gene3D:   G3DSA:1.10.540.10
- Gene3D:   G3DSA:1.20.140.10

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N; SSF56645 AcylCoA_dehyd_NM; SSF47203 AcylCoADH_C_like

EC number: NA

Molecular weight: Translated: 41447; Mature: 41447

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00072 ACYL_COA_DH_1; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYG
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCHHCCCCCHHHHHHHHHHHHHHHC
GAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNGGVADIYIVFAVTDPEKKKKG
CCEEEECCCCCCCCCCHHHHHHHCCCCEEECCCEEEEECCCCEEEEEEEEECCCHHHHCC
VTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLD
CEEEEEEECCCHHHCCCHHHCCCCCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQ
HHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLAD
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFREMANLGLTGIPWPEDYG
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFGTEEQKTEYLTQLALGEKI
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCHHCCCCCHHHHHHHHHHHHHHHC
GAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNGGVADIYIVFAVTDPEKKKKG
CCEEEECCCCCCCCCCHHHHHHHCCCCEEECCCEEEEECCCCEEEEEEEEECCCHHHHCC
VTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCVVPASKRLGEEGEGFKIAMKTLD
CEEEEEEECCCHHHCCCHHHCCCCCCCCCHHHHHHHHCCCHHHHCCCCCCCEEEEEEECC
GGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIAEQQGIAFKLADMATMIEASRLLTY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHH
QAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEAVQIFGGYGYTKDYPVERYMRDAKITQ
HHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
IYEGTQEIQRLVISRMLAD
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377