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The map label for this gene is tdk

Identifier: 16080759

GI number: 16080759

Start: 3802405

End: 3802992

Strand: Reverse

Name: tdk

Synonym: BSU37060

Alternate gene names: 16080759

Gene position: 3802992-3802405 (Counterclockwise)

Preceding gene: 16080760

Following gene: 16080758

Centisome position: 90.21

GC content: 46.77

Gene sequence:

>588_bases
ATGTACATAATGAAACAAAGCGGGTGGCTTGAGCTGATTTGCGGCAGCATGTTCTCGGGGAAATCTGAAGAGCTGATCAG
AAGAGTGAAGAGAGCAACTTATGCCAAGCAGGAAGTCAGGGTATTTAAGCCTGTAATTGATAACCGATACAGCGAAGCTG
CTGTTGTCTCCCATAATGGAACATCGATGACGAGCTATGCCATTTCGTCTGCTGCGGACATTTGGGATCACATCAGTGAA
AGTACAGATGTGGTTGCGGTTGATGAAGTGCAGTTTTTTGATCAGGAAATTGTTGAGGTTTTATCATCTCTTGCCGATAA
AGGCTACCGTGTGATAGCAGCAGGCCTTGATATGGATTTTAGGGGAGAGCCGTTCGGTGTCGTCCCGAATATCATGGCGA
TTGCGGAAAGTGTGACAAAGCTGCAAGCCGTCTGTTCTGTTTGCGGATCACCGGCGAGCAGAACACAGCGCCTCATTGAC
GGCAAACCTGCTTCTTACGATGATCCGGTCATTTTGGTTGGTGCAGCTGAATCATATGAAGCAAGATGCAGACATCATCA
CGAAGTCCCAGGTAAATCTAAAAAATAG

Upstream 100 bases:

>100_bases
GGTCTTAAGTAATAATAGATTTCTCAACAGGCAAGCAGCAGTCTTGCCTGTTTTTTATATTGTCTAAAACACAGCTGGCA
GAGAGAGGGGAGCGAAGCCT

Downstream 100 bases:

>100_bases
TCCAAAACATGGGTATAAAGATAGAATGCACCGGCTAAAAACACCGGTGTTTTTTTTATATTCTGATAATATTCAATTAA
AAAATTTAAATAAGTATATT

Product: thymidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 195; Mature: 195

Protein sequence:

>195_residues
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISE
STDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID
GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK

Sequences:

>Translated_195_residues
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISE
STDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID
GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK
>Mature_195_residues
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISE
STDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID
GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK

Specific function: Phosphorylates Both Thymidine And Deoxyuridine. [C]

COG id: COG1435

COG function: function code F; Thymidine kinase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine kinase family

Homologues:

Organism=Homo sapiens, GI164698438, Length=180, Percent_Identity=37.2222222222222, Blast_Score=110, Evalue=9e-25,
Organism=Escherichia coli, GI1787490, Length=184, Percent_Identity=29.8913043478261, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17543396, Length=184, Percent_Identity=30.4347826086957, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KITH_BACSU (Q03221)

Other databases:

- EMBL:   M97678
- EMBL:   Z49782
- EMBL:   AL009126
- PIR:   S55432
- RefSeq:   NP_391587.1
- ProteinModelPortal:   Q03221
- SMR:   Q03221
- EnsemblBacteria:   EBBACT00000001921
- GeneID:   937033
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU37060
- NMPDR:   fig|224308.1.peg.3713
- GenoList:   BSU37060
- GeneTree:   EBGT00050000002762
- HOGENOM:   HBG522108
- OMA:   NEIRSTP
- PhylomeDB:   Q03221
- ProtClustDB:   PRK04296
- BioCyc:   BSUB:BSU37060-MONOMER
- BRENDA:   2.7.1.21
- GO:   GO:0005737
- HAMAP:   MF_00124
- InterPro:   IPR001267
- InterPro:   IPR020633
- InterPro:   IPR020634
- PANTHER:   PTHR11441
- PIRSF:   PIRSF035805

Pfam domain/function: PF00265 TK

EC number: =2.7.1.21

Molecular weight: Translated: 21451; Mature: 21451

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00603 TK_CELLULAR_TYPE

Important sites: ACT_SITE 89-89

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNG
CEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
TSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDF
CCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC
RGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLIDGKPASYDDPVILVGAAESYE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHH
ARCRHHHEVPGKSKK
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKPVIDNRYSEAAVVSHNG
CEEECCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
TSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLSSLADKGYRVIAAGLDMDF
CCHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCC
RGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLIDGKPASYDDPVILVGAAESYE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCHH
ARCRHHHEVPGKSKK
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8423140; 9353933; 9384377