| Definition | Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome. |
|---|---|
| Accession | NC_000964 |
| Length | 4,215,606 |
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The map label for this gene is yvgN
Identifier: 16080393
GI number: 16080393
Start: 3426749
End: 3427579
Strand: Reverse
Name: yvgN
Synonym: BSU33400
Alternate gene names: 16080393
Gene position: 3427579-3426749 (Counterclockwise)
Preceding gene: 16080395
Following gene: 16080390
Centisome position: 81.31
GC content: 41.16
Gene sequence:
>831_bases GTGCCAACAAGTTTAAAAGATACTGTAAAGTTACATAACGGAGTTGAAATGCCTTGGTTCGGTCTGGGCGTTTTTAAAGT AGAAAATGGTAATGAAGCGACTGAATCAGTGAAAGCGGCAATTAAAAATGGCTATCGCAGTATTGATACAGCAGCGATCT ACAAAAATGAAGAAGGCGTTGGCATCGGGATTAAAGAATCCGGTGTGGCAAGAGAAGAGCTCTTCATCACATCAAAAGTG TGGAATGAAGATCAAGGCTATGAAACAACGCTTGCTGCCTTTGAAAAAAGCCTAGAAAGACTGCAGCTTGATTACTTAGA TTTATATTTGATCCATTGGCCTGGCAAAGATAAATATAAAGATACATGGCGCGCGCTTGAAAAGCTGTACAAAGACGGCA AAATTCGCGCGATCGGCGTCAGCAATTTCCAAGTTCATCATTTAGAAGAGCTGTTGAAAGATGCTGAAATCAAACCGATG GTGAACCAAGTTGAATTTCACCCTCGCTTGACGCAAAAAGAATTAAGAGATTACTGCAAAGGGCAAGGCATTCAGCTGGA AGCGTGGTCTCCGCTCATGCAGGGACAGCTTTTGGATAACGAAGTACTGACACAGATTGCTGAAAAACACAATAAATCTG TGGCTCAAGTGATTTTGCGCTGGGATCTGCAGCATGGAGTTGTAACCATTCCAAAATCCATTAAAGAACACCGTATCATC GAAAACGCTGATATTTTTGATTTCGAATTGTCTCAAGAAGACATGGACAAAATTGACGCATTAAATAAAGATGAGCGTGT CGGTCCAAATCCTGATGAGCTTCTGTTTTAA
Upstream 100 bases:
>100_bases AAGAAGCAAAAAGAGGGTCTTAAGCGTATTATTGGTATCGGCTGAGAGGAATGTGAGATAATATAGACGCTTACATTTCA GTGAAAGGGTGGAGGTTCAA
Downstream 100 bases:
>100_bases TCAAAAAACTCCCCGTTATGGGGAGTTTTTTTAGTGCGTTTTTTTCTGTTGAATGAAAAACAGCATCAAAAAGGAAATGA CAACAATACAGACGACCCAC
Product: glyoxal/methylglyoxal reductase
Products: NA
Alternate protein names: GR; Methylglyoxal reductase
Number of amino acids: Translated: 276; Mature: 275
Protein sequence:
>276_residues MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKV WNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRII ENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF
Sequences:
>Translated_276_residues MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKV WNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRII ENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF >Mature_275_residues PTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVW NEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMV NQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRIIE NADIFDFELSQEDMDKIDALNKDERVGPNPDELLF
Specific function: Reduces glyoxal and methylglyoxal. Is not involved in the vitamin B6 biosynthesis
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family
Homologues:
Organism=Homo sapiens, GI24497577, Length=295, Percent_Identity=41.3559322033898, Blast_Score=226, Evalue=1e-59, Organism=Homo sapiens, GI5174391, Length=295, Percent_Identity=41.3559322033898, Blast_Score=226, Evalue=1e-59, Organism=Homo sapiens, GI223468663, Length=294, Percent_Identity=40.8163265306122, Blast_Score=208, Evalue=4e-54, Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=39.0163934426229, Blast_Score=199, Evalue=2e-51, Organism=Homo sapiens, GI310109922, Length=278, Percent_Identity=40.2877697841727, Blast_Score=198, Evalue=4e-51, Organism=Homo sapiens, GI5453543, Length=298, Percent_Identity=38.9261744966443, Blast_Score=197, Evalue=1e-50, Organism=Homo sapiens, GI310109920, Length=298, Percent_Identity=38.9261744966443, Blast_Score=196, Evalue=1e-50, Organism=Homo sapiens, GI45446745, Length=298, Percent_Identity=38.9261744966443, Blast_Score=196, Evalue=2e-50, Organism=Homo sapiens, GI4503285, Length=298, Percent_Identity=38.9261744966443, Blast_Score=196, Evalue=2e-50, Organism=Homo sapiens, GI4502049, Length=293, Percent_Identity=42.6621160409556, Blast_Score=194, Evalue=9e-50, Organism=Homo sapiens, GI24497585, Length=297, Percent_Identity=38.7205387205387, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI291291012, Length=269, Percent_Identity=40.5204460966543, Blast_Score=190, Evalue=1e-48, Organism=Homo sapiens, GI24497583, Length=296, Percent_Identity=38.1756756756757, Blast_Score=187, Evalue=7e-48, Organism=Homo sapiens, GI5174695, Length=298, Percent_Identity=37.248322147651, Blast_Score=184, Evalue=9e-47, Organism=Homo sapiens, GI300116273, Length=277, Percent_Identity=35.3790613718412, Blast_Score=159, Evalue=3e-39, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=35.8695652173913, Blast_Score=152, Evalue=3e-37, Organism=Homo sapiens, GI310109924, Length=154, Percent_Identity=39.6103896103896, Blast_Score=111, Evalue=8e-25, Organism=Homo sapiens, GI310109926, Length=113, Percent_Identity=44.2477876106195, Blast_Score=96, Evalue=4e-20, Organism=Homo sapiens, GI207028673, Length=113, Percent_Identity=44.2477876106195, Blast_Score=96, Evalue=5e-20, Organism=Escherichia coli, GI87082198, Length=271, Percent_Identity=45.0184501845018, Blast_Score=255, Evalue=2e-69, Organism=Escherichia coli, GI1786400, Length=257, Percent_Identity=36.9649805447471, Blast_Score=174, Evalue=6e-45, Organism=Escherichia coli, GI1788081, Length=271, Percent_Identity=35.0553505535055, Blast_Score=142, Evalue=3e-35, Organism=Escherichia coli, GI1788070, Length=217, Percent_Identity=28.110599078341, Blast_Score=74, Evalue=1e-14, Organism=Escherichia coli, GI87081735, Length=278, Percent_Identity=24.8201438848921, Blast_Score=68, Evalue=7e-13, Organism=Escherichia coli, GI1789199, Length=235, Percent_Identity=30.6382978723404, Blast_Score=67, Evalue=9e-13, Organism=Caenorhabditis elegans, GI71998625, Length=268, Percent_Identity=44.0298507462687, Blast_Score=226, Evalue=1e-59, Organism=Caenorhabditis elegans, GI17564128, Length=300, Percent_Identity=39, Blast_Score=211, Evalue=4e-55, Organism=Caenorhabditis elegans, GI17537077, Length=295, Percent_Identity=40.3389830508475, Blast_Score=202, Evalue=1e-52, Organism=Caenorhabditis elegans, GI17537075, Length=300, Percent_Identity=40.3333333333333, Blast_Score=201, Evalue=3e-52, Organism=Caenorhabditis elegans, GI17537079, Length=307, Percent_Identity=37.785016286645, Blast_Score=190, Evalue=6e-49, Organism=Caenorhabditis elegans, GI17561298, Length=274, Percent_Identity=36.1313868613139, Blast_Score=190, Evalue=7e-49, Organism=Caenorhabditis elegans, GI17538386, Length=272, Percent_Identity=38.9705882352941, Blast_Score=186, Evalue=1e-47, Organism=Caenorhabditis elegans, GI17550248, Length=298, Percent_Identity=36.9127516778523, Blast_Score=182, Evalue=1e-46, Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=32.6007326007326, Blast_Score=174, Evalue=5e-44, Organism=Caenorhabditis elegans, GI17561300, Length=277, Percent_Identity=36.4620938628159, Blast_Score=168, Evalue=3e-42, Organism=Caenorhabditis elegans, GI17562292, Length=275, Percent_Identity=33.8181818181818, Blast_Score=166, Evalue=9e-42, Organism=Caenorhabditis elegans, GI17566692, Length=294, Percent_Identity=34.3537414965986, Blast_Score=159, Evalue=2e-39, Organism=Caenorhabditis elegans, GI17550246, Length=81, Percent_Identity=48.1481481481481, Blast_Score=67, Evalue=1e-11, Organism=Saccharomyces cerevisiae, GI6324694, Length=300, Percent_Identity=40.6666666666667, Blast_Score=210, Evalue=2e-55, Organism=Saccharomyces cerevisiae, GI6320576, Length=298, Percent_Identity=40.6040268456376, Blast_Score=206, Evalue=2e-54, Organism=Saccharomyces cerevisiae, GI6322556, Length=261, Percent_Identity=38.6973180076628, Blast_Score=184, Evalue=1e-47, Organism=Saccharomyces cerevisiae, GI6321896, Length=312, Percent_Identity=34.9358974358974, Blast_Score=176, Evalue=4e-45, Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=37.2013651877133, Blast_Score=162, Evalue=5e-41, Organism=Saccharomyces cerevisiae, GI6320079, Length=249, Percent_Identity=34.9397590361446, Blast_Score=143, Evalue=3e-35, Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=40.2684563758389, Blast_Score=206, Evalue=2e-53, Organism=Drosophila melanogaster, GI20129731, Length=295, Percent_Identity=37.9661016949153, Blast_Score=191, Evalue=5e-49, Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=38.2252559726962, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI24657054, Length=293, Percent_Identity=38.9078498293515, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI24644950, Length=301, Percent_Identity=36.2126245847176, Blast_Score=179, Evalue=2e-45, Organism=Drosophila melanogaster, GI24662781, Length=295, Percent_Identity=41.0169491525424, Blast_Score=178, Evalue=3e-45, Organism=Drosophila melanogaster, GI21356425, Length=295, Percent_Identity=36.6101694915254, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI24662785, Length=291, Percent_Identity=40.893470790378, Blast_Score=176, Evalue=1e-44, Organism=Drosophila melanogaster, GI45553081, Length=295, Percent_Identity=34.5762711864407, Blast_Score=175, Evalue=4e-44, Organism=Drosophila melanogaster, GI221378297, Length=321, Percent_Identity=33.9563862928349, Blast_Score=172, Evalue=3e-43, Organism=Drosophila melanogaster, GI281366140, Length=256, Percent_Identity=33.984375, Blast_Score=149, Evalue=2e-36,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): GR_BACSU (O32210)
Other databases:
- EMBL: AJ223978 - EMBL: AL009126 - PIR: C70040 - RefSeq: NP_391220.1 - PDB: 3D3F - PDB: 3F7J - PDBsum: 3D3F - PDBsum: 3F7J - ProteinModelPortal: O32210 - SMR: O32210 - EnsemblBacteria: EBBACT00000003783 - GeneID: 936001 - GenomeReviews: AL009126_GR - KEGG: bsu:BSU33400 - NMPDR: fig|224308.1.peg.3346 - GenoList: BSU33400 - GeneTree: EBGT00070000031808 - HOGENOM: HBG605727 - OMA: NKDERVG - PhylomeDB: O32210 - ProtClustDB: CLSK887872 - BioCyc: BSUB:BSU33400-MONOMER - InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 - Gene3D: G3DSA:3.20.20.100 - PANTHER: PTHR11732 - PIRSF: PIRSF000097 - PRINTS: PR00069
Pfam domain/function: PF00248 Aldo_ket_red; SSF51430 Aldo/ket_red
EC number: =1.1.1.283
Molecular weight: Translated: 31663; Mature: 31532
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1; PS00062 ALDOKETO_REDUCTASE_2; PS00063 ALDOKETO_REDUCTASE_3
Important sites: ACT_SITE 54-54 BINDING 112-112
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.8 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGV CCCCHHHHHHHHCCCCCCEECEEEEEECCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCC GIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYK EECCCCCCCCHHHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHH DTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVNQVEFHPRLTQKELRDYCK HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHC GQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRII CCCEEEECCCHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEECCHHHHHHHHH ENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF CCCCEEEEECCHHHHHHHHCCCCCCCCCCCHHHCCC >Mature Secondary Structure PTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNGYRSIDTAAIYKNEEGV CCCHHHHHHHHCCCCCCEECEEEEEECCCCHHHHHHHHHHHHCCCCCCHHEEEECCCCC GIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQLDYLDLYLIHWPGKDKYK EECCCCCCCCHHHHEEEHHHCCCCCCHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCCHH DTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPMVNQVEFHPRLTQKELRDYCK HHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHC GQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVILRWDLQHGVVTIPKSIKEHRII CCCEEEECCCHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCEEECCHHHHHHHHH ENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF CCCCEEEEECCHHHHHHHHCCCCCCCCCCCHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9639930; 9384377