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The map label for this gene is nhaK

Identifier: 16080395

GI number: 16080395

Start: 3428331

End: 3430343

Strand: Reverse

Name: nhaK

Synonym: BSU33420

Alternate gene names: 16080395

Gene position: 3430343-3428331 (Counterclockwise)

Preceding gene: 16080396

Following gene: 16080393

Centisome position: 81.37

GC content: 44.71

Gene sequence:

>2013_bases
TTGGACATATTTTTAGTTGTGCTCGTATTATTAACGATTATTGCGATTTCTAATATCGTGAACCGGTTTATTCCGTTTAT
TCCGGTGCCGCTGATTCAAGTGGCTCTTGGGATTCTTGCCGCCTCATTTCCACAGGGACTTCATTTTGAATTAAACACCG
AATTGTTTTTTGTTCTTTTTATCGCGCCTCTGCTATTTAATGATGGAAAGAGGACACCGCGGGCAGAGCTTTGGAATTTA
AGGGCTCCGATTTTATTGCTTGCACTCGGCCTTGTATTTGCGACTGTGATTGTAGGCGGCTACACGATTCACTGGATGAT
TCCTGCTATTCCGCTGGCAGCGGCCTTTGGACTTGCGGCCATTCTTTCACCGACTGATGTCGTCGCTGTCAGCGCATTAT
CAGGAAGAGTGAAAATGCCAAAAGGGATTCTTCGCCTGCTGGAAGGTGAGGGGCTGATGAATGATGCATCAGGTCTGGTG
GCCTTTAAGTTTGCGATTGCAGCGGCAGTGACTGGTGCATTTTCATTAGCACAAGCGGCTGTCAGCTTTGTCTTTATTTC
TCTCGGAGGCTTGCTGTGCGGGGTTGTCATTTCATTTTTGATTATTCGTTTTCGCCTATTTCTGCGCCGCCTTGGCATGC
AGGATGTCACGATGCATATGCTGATTCAAATTCTGACGCCGTTTGTGATTTATTTGGCAGCTGAAGAAATCGGCGTTTCG
GGCATTTTAGCTGTTGTAGCTGGCGGTATTACCCATGCGGTTGAACAGGATCGTCTGGAATCAACGATGATCAAGCTGCA
AATCGTCTCCTCAAGTACGTGGAACATTATTTTATTTATTTTGAACGGCCTGGTCTTCGTTATTCTCGGCACGCAAATCC
CTGATGTTATTTCTGTTATCTTTAACGACACTGCCATCAGCAACATGAAGGTGATCGGCTATATCCTAGTCATCACATTT
ACATTAATGCTCCTTAGATTCCTGTGGGTGCTGTTCTTCTGGAACGGCAAATGGTTCTTTAATAAAGATCAGAACATCTA
TAAACCGGGTCTTCGTTCGACGCTGTTAATTTCGATTTCCGGTGTGCGTGGAGCAGTAACGCTTGCAGGTTCTTTTTCCA
TTCCGTATTTCCTGGAGGACGGTACGCCGTTTCCGGAAAGAAATCTGATTCTCTTTTTAGCAGCCGGCGTCATTTTATGC
ACGCTTGTCATTGCCACCGTTGTGCTGCCAATTCTGACTGAAAAAGAAGAAGAGGACGAGGAACGAAATAAGAAGCTGCT
GACGGCGAGACGCAAGTTGATCAAAACAGCCCTTCAAACGATTAAAGAGGACATGAATGAGACAAACAAAACGGCCTCTC
TTGCGGTGATAGCTGAATACAATGAGAAAATGAAAAATCTTCGTTTTCAGCAGTATACATCATCTAATCGCATTAAGAAG
CACGAGCGAAAAGTCCGTGCGCAGGGGGTTAAGGCTGAGCAAGAGGCGCTGATGAAAATGCTGGAGCGGGGAGACATCCC
GGAAGAAACAGCAAATGTGCTGCAAGAACGATTTAACGAGTTGGAAATTTTGTATGCCAACCCGTTTAAAGTCGGGTTAT
CAAAAACAAGGCTCAAGAGGCTGATGTATTGGATTTTCTTCGGTGAACATAAAAAGCCGGAGATGTCGATTTTAAATGAA
GCGGGATTGATACGGGCAACAAGAGTGAAAACGGCAAAAGCAGCGATAGAATATCTGGAAAAACATAAGACGGATGAGCA
TAAAGAAGTGTTTTTATCTGTCATTACATTCTATAAGCAGTTAATTTTCAGGCTGGAGCACAGCCATCATGAGTTAAAAT
CAAGTGCCCATTTTGAAAATCAGAAGCTGGAAGTGAAGCTGAAGGCTGTGCAGGCGATCAGAAATGAAATTCAAACGCTC
TTCGAAGAGAGGGAAATTTCCCGGGACATCTCCCATGAGCTTCGCCAATACATTAATGATGTCGAAGCCGCCATGCTTGA
AGGCGGCGAATAA

Upstream 100 bases:

>100_bases
CACATAGCGGATGCAAGGCCACCCTAGCTCAAGGGCTTTTAGACAAACAGATTTTTTGGCTCATCATGCCGACACACAAC
AGACGAAGGAGGTCATGCAT

Downstream 100 bases:

>100_bases
ATGCAGAAAAAAAGCTGGCGTTAGAGCGCCAGCTTTTTTTATATTAAGGGCGATGAAATGCGACAGTGCTGCCATCCCGG
TCGAACCAGCCTCTGAAGGC

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 670; Mature: 670

Protein sequence:

>670_residues
MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNL
RAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV
AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVS
GILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITF
TLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILC
TLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKK
HERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNE
AGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTL
FEEREISRDISHELRQYINDVEAAMLEGGE

Sequences:

>Translated_670_residues
MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNL
RAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV
AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVS
GILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITF
TLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILC
TLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKK
HERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNE
AGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTL
FEEREISRDISHELRQYINDVEAAMLEGGE
>Mature_670_residues
MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNL
RAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV
AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVS
GILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITF
TLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILC
TLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKK
HERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNE
AGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTL
FEEREISRDISHELRQYINDVEAAMLEGGE

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily

Homologues:

Organism=Homo sapiens, GI41872703, Length=511, Percent_Identity=24.26614481409, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=551, Percent_Identity=38.475499092559, Blast_Score=313, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAK_BACSU (O32212)

Other databases:

- EMBL:   AL009126
- PIR:   E70040
- RefSeq:   NP_391222.1
- ProteinModelPortal:   O32212
- EnsemblBacteria:   EBBACT00000002379
- GeneID:   936025
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU33420
- NMPDR:   fig|224308.1.peg.3348
- GenoList:   BSU33420
- GeneTree:   EBGT00050000001157
- HOGENOM:   HBG648988
- OMA:   RETAIIS
- PhylomeDB:   O32212
- ProtClustDB:   CLSK887874
- BioCyc:   BSUB:BSU33420-MONOMER
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- PANTHER:   PTHR10110
- PANTHER:   PTHR10110:SF3
- TIGRFAMs:   TIGR00831

Pfam domain/function: PF00999 Na_H_Exchanger

EC number: NA

Molecular weight: Translated: 75229; Mature: 75229

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11787fd4)-; HASH(0x126f6288)-; HASH(0x12030474)-; HASH(0x117d4154)-; HASH(0x125d9d1c)-; HASH(0x1235a394)-; HASH(0x12062cfc)-; HASH(0x1218e9d8)-; HASH(0x127385a4)-; HASH(0x11782808)-; HASH(0x117ff6d0)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
IAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAA
HHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHH
ILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLVAFKFAIAAAVTGAFSLAQAA
HCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
GILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVI
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
FNDTAISNMKVIGYILVITFTLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISIS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEEE
GVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILCTLVIATVVLPILTEKEEEDE
CCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCHHHHHCCCCHHHH
HERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKR
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHHHCCHHHHHHH
LMYWIFFGEHKKPEMSILNEAGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQ
HHHHHHCCCCCCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTLFEEREISRDISHELRQYIND
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAAMLEGGE
HHHHHHCCCH
>Mature Secondary Structure
MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFPQGLHFELNTELFFVLF
CHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
IAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYTIHWMIPAIPLAAAFGLAA
HHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHH
ILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLVAFKFAIAAAVTGAFSLAQAA
HCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTMHMLIQILTPFVIYLAAEEIGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCHH
GILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNIILFILNGLVFVILGTQIPDVISVI
HHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
FNDTAISNMKVIGYILVITFTLMLLRFLWVLFFWNGKWFFNKDQNIYKPGLRSTLLISIS
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCEEEEEEE
GVRGAVTLAGSFSIPYFLEDGTPFPERNLILFLAAGVILCTLVIATVVLPILTEKEEEDE
CCCEEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
ERNKKLLTARRKLIKTALQTIKEDMNETNKTASLAVIAEYNEKMKNLRFQQYTSSNRIKK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHEEEHHHHHHHHHCCHHHHHCCCCHHHH
HERKVRAQGVKAEQEALMKMLERGDIPEETANVLQERFNELEILYANPFKVGLSKTRLKR
HHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCEEEEEECCHHHCCHHHHHHH
LMYWIFFGEHKKPEMSILNEAGLIRATRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQ
HHHHHHCCCCCCCHHHHHHHCCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
LIFRLEHSHHELKSSAHFENQKLEVKLKAVQAIRNEIQTLFEEREISRDISHELRQYIND
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VEAAMLEGGE
HHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377