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The map label for this gene is fhuB

Identifier: 16080385

GI number: 16080385

Start: 3417222

End: 3418376

Strand: Reverse

Name: fhuB

Synonym: BSU33310

Alternate gene names: 16080385

Gene position: 3418376-3417222 (Counterclockwise)

Preceding gene: 16080387

Following gene: 16080384

Centisome position: 81.09

GC content: 49.09

Gene sequence:

>1155_bases
ATGCATTTTCATTTTTGTTCAAAACACTCTATTAAATCAGCTGAAAAAAGTGATATACTGAAACAGCAATTGATAATCAT
TATCAGTAACAGAAAGGAAGTACGGCAGTTGAGTCAACATAAAAATATACGGACTGCATCAGAAGAAATCCAATGGACGT
CAAGGACATATGGCGCGGTCATCGTCCTTATCGCAGGTCTATGCCTGCTTTGCCTTGGCGCATTTTTATCCATATCCCTA
GGTGCAGCGGATATTCATTTGCGCACTGTATGGGAGGCCATTTTTCATTATCAGCCGACAAAGACATCTCACCAAATTAT
ACATGATCTTCGGCTTCCGAGAACGGCGGCTGCCGCGCTTGTAGGCGCATTGTTGGCAGTGTCGGGAGCAATCATGCAGG
GGATGACGAGAAACCCTTTGGCAGAGCCTTCGATTATGGGTGTGACATCAGGCTCTGCGTTTGCGGTTTCGATTGCGTTT
GCCTTTTTTCCCGGACTTTCTGCAATGGGGCTTGTGCTATGGTCCTTTGCGGGAGCGGGGCTGGGGGCATCGACGGTAAT
GGGCATAGGCATGTTTTCAAGGGGCGGACTTACGCCTGTAAAGCTTGCTCTGGCGGGTACGGCAGTTACTTATTTCTTTA
CCGGCATTTCAACTGCCATTGCAATCCGCTTTGATGTCGCTCAGGATATCAGCTTTTGGTACGCAGGCGGGGTAGCGGGT
GTGAAATGGTCGGGGGTCCAGCTTTTGCTTATTGCAGGGGCTGTCGGTTTAACGCTCGCGTTTTTCATCGCCCGGTCTGT
TACAGTGTTAAGTCTCGGTGACGATCTGGCAAAAGGGCTTGGACAATATACATCAGCGGTGAAACTGGTTGGCATGCTTA
TTGTAGTAATTCTGACCGGAGCTGCGGTTTCCATTGCCGGCACCATTGCATTTATCGGGCTGATCATTCCGCATATTACC
CGTTTTTTGGTCGGTGTGGATTATCGGTGGATCATTCCTTGCTCGGCGGTGCTCGGTGCTGTTTTGCTTGTTTTTGCTGA
CATAGCGGCCAGACTCGTAAATGCGCCCTTTGAAACGCCTGTCGGCGCGCTGACTTCTCTTATCGGCGTTCCCTTTTTCT
TTTATTTGGCACGTCGTGAAAGGAGAGGGCTGTAA

Upstream 100 bases:

>100_bases
CATATCTCATACCTTCTTTCTAAAAGATAGATGAAAAAGAGAATCATTATCATCTGTGATTATACCACTGCAAGTGCCGG
TTGACACGATATTTTTGCAA

Downstream 100 bases:

>100_bases
TGAAAACAAAAACAAACAAACCGCTCATTGTAATGGCTGTGACCTTTTTGCTTATCGTGGTGGTCTTTTTTATCAGTCTC
AATTTGGGCGTTATCAAAAT

Product: ferrichrome ABC transporter permease

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISL
GAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF
AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAG
VKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHIT
RFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL

Sequences:

>Translated_384_residues
MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISL
GAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF
AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAG
VKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHIT
RFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL
>Mature_384_residues
MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISL
GAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF
AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAG
VKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHIT
RFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily

Homologues:

Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=37.6623376623377, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI1790741, Length=324, Percent_Identity=35.1851851851852, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1790740, Length=312, Percent_Identity=34.6153846153846, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1786347, Length=293, Percent_Identity=34.4709897610922, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=35.8885017421603, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786804, Length=312, Percent_Identity=31.7307692307692, Blast_Score=99, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FHUB_BACSU (P49936)

Other databases:

- EMBL:   X93092
- EMBL:   AJ223978
- EMBL:   AL009126
- EMBL:   M87283
- PIR:   A69622
- RefSeq:   NP_391212.1
- ProteinModelPortal:   P49936
- SMR:   P49936
- EnsemblBacteria:   EBBACT00000000155
- GeneID:   937085
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU33310
- NMPDR:   fig|224308.1.peg.3338
- GenoList:   BSU33310
- GeneTree:   EBGT00070000031782
- HOGENOM:   HBG700016
- OMA:   DGSITHH
- PhylomeDB:   P49936
- ProtClustDB:   CLSK2301484
- BioCyc:   BSUB:BSU33310-MONOMER
- InterPro:   IPR000522

Pfam domain/function: PF01032 FecCD

EC number: NA

Molecular weight: Translated: 40721; Mature: 40721

Theoretical pI: Translated: 10.30; Mature: 10.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x11fdc178)-; HASH(0x124a1050)-; HASH(0x11b58c24)-; HASH(0x11e6d70c)-; HASH(0xeead800)-; HASH(0xf008e10)-; HASH(0xeead938)-; HASH(0x126b4a08)-; HASH(0x120a268c)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAV
CCCCCCCCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
VGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAFAFFPGLSAMGLVLWSFAGAG
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
LGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAG
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCCCCCC
VKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTG
CEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VGALTSLIGVPFFFYLARRERRGL
HHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIRTASEEIQWTSRTYGAV
CCCCCCCCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
IVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKTSHQIIHDLRLPRTAAAAL
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
VGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAFAFFPGLSAMGLVLWSFAGAG
HHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCC
LGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGISTAIAIRFDVAQDISFWYAGGVAG
CCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHCCCCCC
VKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDLAKGLGQYTSAVKLVGMLIVVILTG
CEECCCHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHC
AAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPCSAVLGAVLLVFADIAARLVNAPFETP
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
VGALTSLIGVPFFFYLARRERRGL
HHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528