Click here to switch to the map view.

The map label for this gene is comA

Identifier: 16080219

GI number: 16080219

Start: 3252804

End: 3253448

Strand: Reverse

Name: comA

Synonym: BSU31680

Alternate gene names: 16080219

Gene position: 3253448-3252804 (Counterclockwise)

Preceding gene: 255767724

Following gene: 255767723

Centisome position: 77.18

GC content: 41.55

Gene sequence:

>645_bases
ATGAAAAAGATACTAGTGATTGATGACCATCCGGCTGTCATGGAAGGCACCAAGACAATTTTGGAAACGGATTCGAATTT
GTCTGTTGATTGTCTCAGTCCTGAACCGAGCGAACAGTTTATCAAGCAGCATGATTTCTCGTCATATGATCTCATTTTAA
TGGATCTGAATCTAGGCGGCGAGGTCAATGGGATGGAGCTTTCTAAACAGATTTTACAAGAGAATCCTCATTGTAAAATT
ATCGTGTATACCGGTTATGAGGTCGAGGATTATTTCGAGGAAGCGATTCGTGCGGGTCTGCACGGTGCCATCAGCAAAAC
GGAATCTAAAGAAAAGATCACCCAATACATATACCACGTACTCAACGGAGAAATTTTAGTCGATTTTGCTTACTTTAAAC
AGCTGATGACTCAGCAAAAAACAAAGCCGGCTCCTTCCTCTCAAAAAGAACAAGATGTGCTCACACCTAGAGAATGCCTG
ATTCTTCAAGAAGTTGAAAAGGGATTTACAAACCAAGAAATCGCAGATGCCCTTCATTTAAGCAAGCGGTCCATTGAATA
CAGCTTGACATCGATTTTCAATAAGCTGAATGTCGGTTCACGGACGGAAGCGGTTTTGATTGCGAAATCAGACGGTGTAC
TTTAA

Upstream 100 bases:

>100_bases
ATATTGAAATCGAATTGTAATGGATTTATAACGGAAACGACTTGGCACAGGCCAAGTCTTTTTTATAAAATGGAAAAGAG
TGAGTAAAAGGGAGGAAAAC

Downstream 100 bases:

>100_bases
ATGTTGGGGGGTGTAGAGATGGATATGAAGCACACATTGCTTGAAGCGCTTGGTATTGAGATTGTTGAAAACACAGCGGA
ACGATGCGTTGCGGTCATGC

Product: two-component response regulator

Products: NA

Alternate protein names: Competence protein A

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKI
IVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL
ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL

Sequences:

>Translated_214_residues
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKI
IVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL
ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL
>Mature_214_residues
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKI
IVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL
ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL

Specific function: Response regulator in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Regulates directly the expression of over 20 genes, including genes of the srfA operon, d

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1786747, Length=207, Percent_Identity=26.5700483091787, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788521, Length=226, Percent_Identity=26.1061946902655, Blast_Score=70, Evalue=7e-14,
Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=26.5116279069767, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CMPA_BACSU (P14204)

Other databases:

- EMBL:   M22856
- EMBL:   Z93932
- EMBL:   AL009126
- PIR:   A33591
- RefSeq:   NP_391046.1
- PDB:   2KRF
- PDBsum:   2KRF
- ProteinModelPortal:   P14204
- SMR:   P14204
- EnsemblBacteria:   EBBACT00000002592
- GeneID:   937179
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU31680
- GenoList:   BSU31680
- GeneTree:   EBGT00070000032004
- HOGENOM:   HBG753323
- OMA:   YDVYLID
- ProtClustDB:   CLSK887804
- BioCyc:   BSUB:BSU31680-MONOMER
- GO:   GO:0005737
- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00038
- SMART:   SM00421
- SMART:   SM00448

Pfam domain/function: PF00196 GerE; PF00072 Response_reg; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 24129; Mature: 24129

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00622 HTH_LUXR_1; PS50043 HTH_LUXR_2; PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGG
CCEEEEECCCCCHHHCCHHHEECCCCCEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCC
EVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHV
CCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECLILQEVEKGFTNQEIADALHL
HCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHH
SKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQHDFSSYDLILMDLNLGG
CCEEEEECCCCCHHHCCHHHEECCCCCEEEECCCCCHHHHHHHCCCCCCEEEEEEECCCC
EVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHGAISKTESKEKITQYIYHV
CCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECLILQEVEKGFTNQEIADALHL
HCCCEEEEHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHH
SKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL
HHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2507523; 9274030; 9384377