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The map label for this gene is comP

Identifier: 255767724

GI number: 255767724

Start: 3253529

End: 3255838

Strand: Reverse

Name: comP

Synonym: BSU31690

Alternate gene names: 255767724

Gene position: 3255838-3253529 (Counterclockwise)

Preceding gene: 16080221

Following gene: 16080219

Centisome position: 77.23

GC content: 34.94

Gene sequence:

>2310_bases
TTGAAGAACTTAATAAAAAAATTCACAATAGCTGTAATTGTTTTGAGTATCCTTTATATAAGCTATACAACTTATATCAG
TATGAATGGAATTATTATTGGGACTAAGATTCATAAAAATGATAAAAGTCAATTTATGATAGAAGAAATATCGGAATCTT
CATATGGACAATTTGTTGGTCTGAGACAGGGAGACATCATATTAAAAATTAATAAAGAAAAACCTTCAGACAAACATTTG
AAATGGGGATATTTGAGTCATATTAACAGTCTGGATATTTTGAGAAGTGGAAAAAAGATTCATCTCAAAGATTTTGATTT
AGTTACTCTAAATAGACCTTATAGTTTTTTTCTGTTCGTACTTCCTTTGTTTTTTTATTTTTTAAGCATAATATGTATTT
TTTATATACTTAAAGTAAATAAAAAAAGGAGATCATTTGCTGCCTATATTCTTATTCTATTGTTATTAGACATTTCGATA
GCATATATAAGTGCAGGCGGACCATTTAGAGGACATATAATCAATCGGTATATTAACTTGTTTACTTTTATATCTTCTCC
TATTCTTTATCTTCAATTTATACAAAGATACCTTGGAGAAATAGGTAAAACTTTTTTGAATAGAATTTCTTTTCTTTATA
TCATACCAATATTTAATCTTGGTATTGAGTTTTTTCAAGACTATTTACAAGTAGATATTGATTTTTTAGCAACTCTTAAT
TTGGTTTCTTTTGCAACTTTGACTCTATTTTCTTTTTCAGCGATATACTTACATCTTAATAAATATAAATATGCTGAGCA
TTCGTTTATTCTTAAATTACTAATTTTAACAAACACTCTTTCATTTGCGCCTTTTTTGATATTTTTTGTTCTTCCAATAA
TATTTACAGGTAATTATATTTTCCCGGCATTAGCTTCGGCGTCATTACTAGTACTAATTCCGTTCGGGTTAGTATACCAA
TTTGTAGCCAATAAGATGTTTGATATAGAGTTTATCTTAGGAAGAATGAGATACTATGCTCTACTTGCCATGATACCAAC
TCTTCTAATAGTTGGTGCATTAGTTCTGTTTGATGTAATGGACATCCAGATGAACCCTGTGCGTCAAACTGTATTTTTTT
TCGTTGTCATGTTCGCTGTCTTTTATTTTAAAGAGGTCATGGATTTTAAATTTCGGTTAAAACGTTTCTCCGAAAAATTC
AACTATCAGGACAGTATTTTTAAATATACTCAGCTAATGAGGGGTGTAACTTCTCTTCAACAAGTTTTTAAAGAACTGAA
AAATACTATACTGGATGTTTTGCTTGTAAGCAAAGCTTATACCTTTGAGGTTACTCCTGATCACAAAGTGATATTTTTAG
ATAAGCATGAAGTTGGACCGGACTGGAATTTTTATCAAGAGGAATTTGAAAACGTAACTTCAGAAATTGGGAAAATTATA
GAAGTCAATCAAGGCTTTCTTATGAAAGTTGGTGAACGAGGCGGTAGTTCTTATGTTCTGCTTTGTTTATCTAATATTAA
CACTCCCCGGCTAACACGTGATGAAATATCGTGGCTGAAAACACTGTCTTTTTATACAAGTGTGTCCATGGAAAATGTCC
TGCATATTGAGGAGCTCATGGAACATTTGAAGGACTTAAAACAAGAGGGAACCAACCCCATCTGGCTGAAAAAGCTAATG
TTTGCAATCGAAGAAAAACAGCGTTCAGGACTCGCCCGCGATCTCCACGATTCGGTTCTTCAGGATTTGATTTCCTTAAA
ACGCCAGTGTGAGCTGTTTTTGGGTGATTTCAAGAAGGATGATAATCCGTGCCGTGAAGAGGTGCAGGACAAGCTTGTAC
AGATGAATGAGCAGATGTCTGATGTGATTTCGATGACGAGGGAGACGTGTCATGAGCTGCGGCCGCAGCTTCTGTATGAT
CTTGGATTGGTGAAGGCGCTGTCGAAGCTGGTGGCGCAGCAGCAGGAGCGGGTTCCGTTTCATATCCGTTTAAATACCGG
GAGATTTACGGCTTCCCTTGATCTGGATTCGCAGCTGAATTTGTACCGGATCATTCAAGAGTTTCTGTCTAATGCGGTCA
AGCACTCTCAGGCGACGGATGTGCTGATTATGCTCATCAGTATTCAAAACAAAATCGTTCTTCATTATGAGGACGATGGC
GTTGGGTTTGATCAAGAAAAAAATACTGAGCATTCCATGAGCATGGGGCTTTCTGGCATTAAGGAGAGAGTCAGGGCTTT
AGATGGGCGCCTTCGGATTGAAACAAGTGAAGGAAAGGGCTTTAAGGCTGATATTGAAATCGAATTGTAA

Upstream 100 bases:

>100_bases
TTGATGTGCAAGAAACTGAAACAATAATTAAAGCTTATAATGATTATTATCTGGCTGATCCAATAACCCGTCAATGGGGT
GATTAATAGGTGGATTAATA

Downstream 100 bases:

>100_bases
TGGATTTATAACGGAAACGACTTGGCACAGGCCAAGTCTTTTTTATAAAATGGAAAAGAGTGAGTAAAAGGGAGGAAAAC
ATGAAAAAGATACTAGTGAT

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHL
KWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI
AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLN
LVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQ
FVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKF
NYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKII
EVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLM
FAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYD
LGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDG
VGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL

Sequences:

>Translated_769_residues
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHL
KWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI
AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLN
LVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQ
FVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKF
NYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKII
EVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLM
FAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYD
LGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDG
VGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL
>Mature_769_residues
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHL
KWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI
AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLN
LVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQ
FVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKF
NYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKII
EVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLM
FAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYD
LGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDG
VGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL

Specific function: Sensor in the two-component regulatory system ComP/ComA involved in a major quorum response pathway that regulates the development of genetic competence. Plays a role in sporulation, at least partly interchangeable with that of SpoIIJ. Probably activates

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1787474, Length=200, Percent_Identity=28, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1788812, Length=196, Percent_Identity=26.0204081632653, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082311, Length=227, Percent_Identity=27.7533039647577, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COMP_BACSU (Q99027)

Other databases:

- EMBL:   X54010
- EMBL:   M22856
- EMBL:   Z93932
- EMBL:   AL009126
- EMBL:   M71283
- PIR:   A35848
- PIR:   B69604
- RefSeq:   NP_391047.2
- ProteinModelPortal:   Q99027
- EnsemblBacteria:   EBBACT00000002553
- GeneID:   938866
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU31690
- NMPDR:   fig|224308.1.peg.3172
- GenoList:   BSU31690
- GeneTree:   EBGT00070000032202
- HOGENOM:   HBG338265
- ProtClustDB:   CLSK887805
- BioCyc:   BSUB:BSU31690-MONOMER
- BRENDA:   2.7.13.3
- InterPro:   IPR003594
- InterPro:   IPR011712
- InterPro:   IPR005467
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 89310; Mature: 89310

Theoretical pI: Translated: 8.36; Mature: 8.36

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x110f0a80)-; HASH(0x11d8c694)-; HASH(0x117c1550)-; HASH(0x11e60f8c)-; HASH(0x11c6fed0)-; HASH(0x120ff080)-; HASH(0x11f6039c)-; HASH(0x12079e04)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVG
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEECCCCHHHHHHHHCCCCCCCEEE
LRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFV
EECCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHCCCEEEEECCEEEEECCCHHHHHHH
LPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISIAYISAGGPFRGHIINRYINL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
FTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYI
HHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FPALASASLLVLIPFGLVYQFVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVM
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKFNYQDSIFKYTQLMRGVTSLQ
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKII
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHE
EVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELM
ECCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHLKDLKQEGTNPIWLKKLMFAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
HIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDG
EEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCEEEEEECCCC
VGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL
CCCCCCCCCHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEH
>Mature Secondary Structure
MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQFMIEEISESSYGQFVG
CHHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEECCCCHHHHHHHHCCCCCCCEEE
LRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHLKDFDLVTLNRPYSFFLFV
EECCCEEEEECCCCCCCCCCCCHHHHHCCHHHHHHCCCEEEEECCEEEEECCCHHHHHHH
LPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISIAYISAGGPFRGHIINRYINL
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
FTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIFNLGIEFFQDYLQVDIDFLATLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLILTNTLSFAPFLIFFVLPIIFTGNYI
HHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
FPALASASLLVLIPFGLVYQFVANKMFDIEFILGRMRYYALLAMIPTLLIVGALVLFDVM
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFRLKRFSEKFNYQDSIFKYTQLMRGVTSLQ
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
QVFKELKNTILDVLLVSKAYTFEVTPDHKVIFLDKHEVGPDWNFYQEEFENVTSEIGKII
HHHHHHHHHHHHHHHHHCCEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHE
EVNQGFLMKVGERGGSSYVLLCLSNINTPRLTRDEISWLKTLSFYTSVSMENVLHIEELM
ECCCCCEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EHLKDLKQEGTNPIWLKKLMFAIEEKQRSGLARDLHDSVLQDLISLKRQCELFLGDFKKD
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DNPCREEVQDKLVQMNEQMSDVISMTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
HIRLNTGRFTASLDLDSQLNLYRIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDG
EEEEECCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHEEECCCEEEEEECCCC
VGFDQEKNTEHSMSMGLSGIKERVRALDGRLRIETSEGKGFKADIEIEL
CCCCCCCCCHHHHHHCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEEH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2116363; 9274030; 9384377; 1715859