Click here to switch to the map view.

The map label for this gene is bceR

Identifier: 16080092

GI number: 16080092

Start: 3113187

End: 3113882

Strand: Reverse

Name: bceR

Synonym: BSU30400

Alternate gene names: 16080092

Gene position: 3113882-3113187 (Counterclockwise)

Preceding gene: 16080093

Following gene: 16080091

Centisome position: 73.87

GC content: 45.4

Gene sequence:

>696_bases
TTGTTTAAACTTTTGCTGATTGAAGATGATGAATCGCTGTTTCATGAAATCAAGGATCGTTTAACGGGATGGTCCTATGA
TGTATACGGCATTCAGGATTTCAGTCAGGTGCTGCAGGAATTTGCGGCGGTTAATCCTGATTGTGTCATTATTGATGTGC
AGCTGCCTAAATTTGACGGCTTTCATTGGTGCCGTCTGATCCGCTCCCGGTCAAATGTTCCGATTCTCTTTTTATCCTCC
CGGGATCATCCTGCTGATATGGTGATGTCCATGCAGCTCGGGGCAGATGACTTTATTCAAAAGCCATTTCATTTTGATGT
GCTGATCGCGAAAATCCAAGCGATGTTCCGGCGTGTGCACCATTATAATACGGAGCCGAGTACGATTAAAACGTGGTGCG
GCGCTGCTGTAGACGCGGAGCAGAACCTCGTCAGCAATGACAAAGGATCTGTTGAACTGACCAAAAATGAAATGTTCATT
CTAAAACAATTAATAGAGCAAAAAAACAAGATCGTCAGCCGGGAAGAGCTGATCAGAAGCTTGTGGAACGATGAGCGTTT
TGTTAGTGATAATACGCTGACCGTCAATGTCAATCGCCTGCGAAAAAAACTGGACGCCCTGCAGCTTGGTGCATATATCG
AGACAAAGGTGGGCCAGGGCTACATCGCGAAGGAAGAGGACAAGTTCTATGATTAA

Upstream 100 bases:

>100_bases
ATAATGCGAACGAGCCGGCTGAGACAGCCGGCTTTTTCTATAGCGCATGCTGGCGTTTTGCTATACACTTGATAAAAAAG
GAAAAAGTGCGGTGAGTCGA

Downstream 100 bases:

>100_bases
AGCATTCCTTATCGAAAGGCGGAGCTGGATTGCCGCGTTTTTGTTTCAGCAGGCTTTGATGCTGTTCATTGCTTTTGTCG
ATCCTTCCATATCATTTGGG

Product: two-component response regulator controlling resistance to antibiotics affecting the envelope YtsB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAVNPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSS
RDHPADMVMSMQLGADDFIQKPFHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI
LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVGQGYIAKEEDKFYD

Sequences:

>Translated_231_residues
MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAVNPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSS
RDHPADMVMSMQLGADDFIQKPFHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI
LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVGQGYIAKEEDKFYD
>Mature_231_residues
MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAVNPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSS
RDHPADMVMSMQLGADDFIQKPFHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI
LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVGQGYIAKEEDKFYD

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1788394, Length=228, Percent_Identity=29.8245614035088, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=28.2511210762332, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.25, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1790860, Length=218, Percent_Identity=29.3577981651376, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=30.1801801801802, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=25.2252252252252, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=27.1111111111111, Blast_Score=97, Evalue=8e-22,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=25.9911894273128, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790552, Length=231, Percent_Identity=29.8701298701299, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=28.9473684210526, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1786784, Length=232, Percent_Identity=28.0172413793103, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=24.4444444444444, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=25, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCER_BACSU (O34951)

Other databases:

- EMBL:   AF008220
- EMBL:   AL009126
- PIR:   G70000
- RefSeq:   NP_390918.1
- ProteinModelPortal:   O34951
- SMR:   O34951
- EnsemblBacteria:   EBBACT00000000941
- GeneID:   936307
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU30400
- NMPDR:   fig|224308.1.peg.3043
- GenoList:   BSU30400
- GeneTree:   EBGT00070000031831
- HOGENOM:   HBG753323
- OMA:   IETKVGQ
- ProtClustDB:   CLSK873746
- BioCyc:   BSUB:BSU30400-MONOMER
- GO:   GO:0005737
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF46894 Bipartite_resp_reg_C-effector; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 26867; Mature: 26867

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAVNPDCVIIDVQLPKFDG
CEEEEEEECCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
FHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKPFHFDVLIAKIQAMFRRVH
HHHHHHHHCCCCCCEEEEECCCCCHHHHEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
HYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFILKQLIEQKNKIVSREELIRS
HCCCCCCHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHH
LWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVGQGYIAKEEDKFYD
HCCCCEEECCCEEEEEHHHHHHHHHHHHHCHHHHHCCCCCCEECCCCCCCC
>Mature Secondary Structure
MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAVNPDCVIIDVQLPKFDG
CEEEEEEECCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCC
FHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKPFHFDVLIAKIQAMFRRVH
HHHHHHHHCCCCCCEEEEECCCCCHHHHEEHHCCCHHHHCCCCHHHHHHHHHHHHHHHHH
HYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFILKQLIEQKNKIVSREELIRS
HCCCCCCHHHHHHCCCCCCHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHH
LWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVGQGYIAKEEDKFYD
HCCCCEEECCCEEEEEHHHHHHHHHHHHHCHHHHHCCCCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377; 14612242; 12890034