| Definition | Bacillus subtilis subsp. subtilis str. 168 chromosome, complete genome. |
|---|---|
| Accession | NC_000964 |
| Length | 4,215,606 |
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The map label for this gene is ytbE
Identifier: 16079957
GI number: 16079957
Start: 2970038
End: 2970880
Strand: Direct
Name: ytbE
Synonym: BSU29050
Alternate gene names: 16079957
Gene position: 2970038-2970880 (Clockwise)
Preceding gene: 16079956
Following gene: 16079968
Centisome position: 70.45
GC content: 44.01
Gene sequence:
>843_bases ATGACAACACATTTACAAGCAAAAGCAACACTTCATAATGGGGTAGAAATGCCTTGGTTCGGCCTCGGCGTGTTCCAAGT GGAAGAAGGATCTGAACTGGTAAACGCAGTTAAAACTGCCATTGTTCACGGGTACCGCAGTATTGATACTGCAGCAATCT ATGGAAATGAAGCTGGAGTCGGAGAAGGGATTCGGGAAGGCATTGAAGAAGCAGGCATTTCAAGAGAGGATCTGTTTATC ACATCGAAAGTATGGAATGCGGATTTAGGCTACGAAGAAACACTCGCCGCGTTTGAAACAAGTCTGTCCAAACTCGGTCT GGATTATTTGGATCTATACCTCATCCACTGGCCTGTAGAAGGAAAGTATAAAGAAGCTTGGAGAGCGCTTGAAACGCTGT ATAAAGAAGGCCGTATCAAAGCGATTGGCGTAAGCAACTTCCAAATTCACCATCTTGAAGATCTGATGACGGCAGCTGAA ATTAAGCCTATGATTAACCAAGTGGAATTTCACCCGCGCCTCACACAAAAAGAGTTGATAAGATACTGCCAAAATCAGGG CATCCAGATGGAGGCTTGGTCACCTTTAATGCAGGGACAGCTGCTGGATCACCCTGTATTGGCTGACATCGCTCAAACAT ATAATAAATCTGTCGCACAAATTATTTTGCGCTGGGATCTGCAGCATGGCATTATAACGATTCCTAAATCAACGAAGGAA CACCGCATTAAAGAAAATGCAAGCGTATTTGACTTTGAATTAACGCAGGATGACATGAACCGAATCGATGCACTGAATGA AAACTTGCGCGTCGGTCCTGATCCGGACAACTTTGATTTTTAA
Upstream 100 bases:
>100_bases GATTAATGGTGGTCGGTGCAGTCATTTTAACAGGCTGGAGCCGCTTGATGGAAAAACGAGATCGGCAGGAAGCCTGACAA TTTTAAAGGAGGAAATAAAC
Downstream 100 bases:
>100_bases TGGCCAAAAAACACCGTTCAATATGAACGGTGTTTTTTGTATTATGCCCAGCTGTTCATGATTTCATCAAGCTGCCTTTT GGTCTCTTCAAGCGTGCCGC
Product: aldo/keto reductase
Products: 2-keto-L-gulonate; NADP [C]
Alternate protein names: NA
Number of amino acids: Translated: 280; Mature: 279
Protein sequence:
>280_residues MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFI TSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKE HRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF
Sequences:
>Translated_280_residues MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFI TSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKE HRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF >Mature_279_residues TTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFIT SKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAEI KPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKEH RIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF
Specific function: Reduction [C]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family
Homologues:
Organism=Homo sapiens, GI24497577, Length=291, Percent_Identity=40.5498281786942, Blast_Score=229, Evalue=2e-60, Organism=Homo sapiens, GI5174391, Length=291, Percent_Identity=40.5498281786942, Blast_Score=229, Evalue=2e-60, Organism=Homo sapiens, GI223468663, Length=292, Percent_Identity=41.0958904109589, Blast_Score=210, Evalue=1e-54, Organism=Homo sapiens, GI93277124, Length=305, Percent_Identity=39.344262295082, Blast_Score=201, Evalue=6e-52, Organism=Homo sapiens, GI291291012, Length=277, Percent_Identity=40.4332129963899, Blast_Score=195, Evalue=4e-50, Organism=Homo sapiens, GI310109922, Length=290, Percent_Identity=38.6206896551724, Blast_Score=194, Evalue=6e-50, Organism=Homo sapiens, GI5174695, Length=299, Percent_Identity=37.4581939799331, Blast_Score=193, Evalue=2e-49, Organism=Homo sapiens, GI5453543, Length=310, Percent_Identity=36.7741935483871, Blast_Score=192, Evalue=2e-49, Organism=Homo sapiens, GI310109920, Length=310, Percent_Identity=36.7741935483871, Blast_Score=192, Evalue=3e-49, Organism=Homo sapiens, GI45446745, Length=310, Percent_Identity=36.7741935483871, Blast_Score=192, Evalue=4e-49, Organism=Homo sapiens, GI4503285, Length=310, Percent_Identity=36.7741935483871, Blast_Score=192, Evalue=4e-49, Organism=Homo sapiens, GI24497585, Length=298, Percent_Identity=36.5771812080537, Blast_Score=188, Evalue=4e-48, Organism=Homo sapiens, GI24497583, Length=294, Percent_Identity=36.734693877551, Blast_Score=184, Evalue=9e-47, Organism=Homo sapiens, GI4502049, Length=299, Percent_Identity=39.4648829431438, Blast_Score=183, Evalue=1e-46, Organism=Homo sapiens, GI300116273, Length=278, Percent_Identity=36.3309352517986, Blast_Score=167, Evalue=1e-41, Organism=Homo sapiens, GI300116271, Length=277, Percent_Identity=35.7400722021661, Blast_Score=165, Evalue=4e-41, Organism=Homo sapiens, GI310109924, Length=169, Percent_Identity=35.5029585798817, Blast_Score=109, Evalue=3e-24, Organism=Homo sapiens, GI310109926, Length=114, Percent_Identity=44.7368421052632, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI207028673, Length=114, Percent_Identity=44.7368421052632, Blast_Score=93, Evalue=3e-19, Organism=Escherichia coli, GI87082198, Length=272, Percent_Identity=47.0588235294118, Blast_Score=248, Evalue=2e-67, Organism=Escherichia coli, GI1786400, Length=263, Percent_Identity=36.5019011406844, Blast_Score=166, Evalue=2e-42, Organism=Escherichia coli, GI1788081, Length=265, Percent_Identity=33.2075471698113, Blast_Score=129, Evalue=1e-31, Organism=Escherichia coli, GI1788070, Length=283, Percent_Identity=23.6749116607774, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1787674, Length=270, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI87081735, Length=190, Percent_Identity=27.8947368421053, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17564128, Length=296, Percent_Identity=38.8513513513513, Blast_Score=208, Evalue=2e-54, Organism=Caenorhabditis elegans, GI71998625, Length=271, Percent_Identity=41.3284132841328, Blast_Score=205, Evalue=2e-53, Organism=Caenorhabditis elegans, GI17537077, Length=292, Percent_Identity=39.3835616438356, Blast_Score=196, Evalue=8e-51, Organism=Caenorhabditis elegans, GI17537075, Length=301, Percent_Identity=38.8704318936877, Blast_Score=190, Evalue=7e-49, Organism=Caenorhabditis elegans, GI17552492, Length=273, Percent_Identity=34.4322344322344, Blast_Score=185, Evalue=2e-47, Organism=Caenorhabditis elegans, GI17561298, Length=270, Percent_Identity=35.1851851851852, Blast_Score=181, Evalue=4e-46, Organism=Caenorhabditis elegans, GI17550248, Length=295, Percent_Identity=36.9491525423729, Blast_Score=180, Evalue=8e-46, Organism=Caenorhabditis elegans, GI17538386, Length=271, Percent_Identity=35.0553505535055, Blast_Score=166, Evalue=1e-41, Organism=Caenorhabditis elegans, GI17562292, Length=274, Percent_Identity=32.4817518248175, Blast_Score=165, Evalue=2e-41, Organism=Caenorhabditis elegans, GI17566692, Length=287, Percent_Identity=35.191637630662, Blast_Score=165, Evalue=3e-41, Organism=Caenorhabditis elegans, GI17537079, Length=308, Percent_Identity=32.1428571428571, Blast_Score=162, Evalue=2e-40, Organism=Caenorhabditis elegans, GI17561300, Length=270, Percent_Identity=31.4814814814815, Blast_Score=147, Evalue=4e-36, Organism=Caenorhabditis elegans, GI17550246, Length=77, Percent_Identity=48.0519480519481, Blast_Score=70, Evalue=1e-12, Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=35.9621451104101, Blast_Score=192, Evalue=5e-50, Organism=Saccharomyces cerevisiae, GI6324694, Length=290, Percent_Identity=36.551724137931, Blast_Score=191, Evalue=1e-49, Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=36.5384615384615, Blast_Score=189, Evalue=5e-49, Organism=Saccharomyces cerevisiae, GI6319625, Length=297, Percent_Identity=36.3636363636364, Blast_Score=174, Evalue=1e-44, Organism=Saccharomyces cerevisiae, GI6320576, Length=294, Percent_Identity=34.3537414965986, Blast_Score=171, Evalue=9e-44, Organism=Saccharomyces cerevisiae, GI6320079, Length=302, Percent_Identity=33.112582781457, Blast_Score=141, Evalue=1e-34, Organism=Drosophila melanogaster, GI24662789, Length=293, Percent_Identity=39.9317406143345, Blast_Score=211, Evalue=6e-55, Organism=Drosophila melanogaster, GI24663317, Length=298, Percent_Identity=38.5906040268456, Blast_Score=203, Evalue=8e-53, Organism=Drosophila melanogaster, GI24657054, Length=302, Percent_Identity=39.7350993377483, Blast_Score=200, Evalue=1e-51, Organism=Drosophila melanogaster, GI24644950, Length=300, Percent_Identity=34.3333333333333, Blast_Score=189, Evalue=2e-48, Organism=Drosophila melanogaster, GI20129731, Length=295, Percent_Identity=36.271186440678, Blast_Score=185, Evalue=3e-47, Organism=Drosophila melanogaster, GI221378297, Length=320, Percent_Identity=32.1875, Blast_Score=181, Evalue=4e-46, Organism=Drosophila melanogaster, GI24662785, Length=297, Percent_Identity=40.0673400673401, Blast_Score=179, Evalue=1e-45, Organism=Drosophila melanogaster, GI24662781, Length=293, Percent_Identity=40.2730375426621, Blast_Score=177, Evalue=6e-45, Organism=Drosophila melanogaster, GI21356425, Length=292, Percent_Identity=35.958904109589, Blast_Score=173, Evalue=1e-43, Organism=Drosophila melanogaster, GI45553081, Length=298, Percent_Identity=33.2214765100671, Blast_Score=163, Evalue=1e-40, Organism=Drosophila melanogaster, GI281366140, Length=259, Percent_Identity=32.8185328185328, Blast_Score=143, Evalue=1e-34,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): YTBE_BACSU (O34678)
Other databases:
- EMBL: AF008220 - EMBL: AL009126 - PIR: D69988 - RefSeq: NP_390783.1 - PDB: 3B3D - PDBsum: 3B3D - ProteinModelPortal: O34678 - SMR: O34678 - EnsemblBacteria: EBBACT00000003708 - GeneID: 937384 - GenomeReviews: AL009126_GR - KEGG: bsu:BSU29050 - NMPDR: fig|224308.1.peg.2908 - GenoList: BSU29050 - GeneTree: EBGT00070000031808 - HOGENOM: HBG605727 - OMA: ETTIAAY - PhylomeDB: O34678 - ProtClustDB: CLSK2518259 - BioCyc: BSUB:BSU29050-MONOMER - InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 - Gene3D: G3DSA:3.20.20.100 - PANTHER: PTHR11732 - PIRSF: PIRSF000097 - PRINTS: PR00069
Pfam domain/function: PF00248 Aldo_ket_red; SSF51430 Aldo/ket_red
EC number: NA
Molecular weight: Translated: 31768; Mature: 31637
Theoretical pI: Translated: 4.72; Mature: 4.72
Prosite motif: PS00798 ALDOKETO_REDUCTASE_1; PS00062 ALDOKETO_REDUCTASE_2; PS00063 ALDOKETO_REDUCTASE_3
Important sites: ACT_SITE 54-54 BINDING 116-116
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.2 %Met (Mature Protein) 2.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGV CCCCCCHHHHHHCCCCCCEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC GEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVE CHHHHHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEEECCCC GKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAEIKPMINQVEFHPRLTQKELI CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH RYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKE HHHHCCCCEEHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHH HRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF HHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCC >Mature Secondary Structure TTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHGYRSIDTAAIYGNEAGV CCCCCHHHHHHCCCCCCEECCEEEEECCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCC GEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSLSKLGLDYLDLYLIHWPVE CHHHHHHHHHHCCCHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHCHHHEEEEEEECCCC GKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAEIKPMINQVEFHPRLTQKELI CCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH RYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSVAQIILRWDLQHGIITIPKSTKE HHHHCCCCEEHHCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHH HRIKENASVFDFELTQDDMNRIDALNENLRVGPDPDNFDF HHHHCCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: 2,5-diketo-D-gluconate; NADPH [C]
Specific reaction: 2,5-diketo-D-gluconate + NADPH = 2-keto-L-gulonate + NADP [C]
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9387221; 9384377