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The map label for this gene is trxA

Identifier: 16079902

GI number: 16079902

Start: 2913024

End: 2913338

Strand: Reverse

Name: trxA

Synonym: BSU28500

Alternate gene names: 16079902

Gene position: 2913338-2913024 (Counterclockwise)

Preceding gene: 255767658

Following gene: 255767657

Centisome position: 69.11

GC content: 42.54

Gene sequence:

>315_bases
ATGGCTATCGTAAAAGCAACTGATCAATCTTTCTCAGCTGAAACAAGCGAAGGCGTCGTACTGGCAGACTTCTGGGCTCC
TTGGTGCGGACCTTGTAAAATGATTGCACCTGTTCTTGAAGAATTGGATCAAGAAATGGGAGACAAACTGAAAATCGTAA
AAATCGATGTAGACGAAAACCAAGAAACTGCCGGAAAATACGGCGTTATGAGCATCCCGACTCTTCTTGTGTTAAAAGAC
GGCGAAGTAGTTGAAACTTCAGTCGGCTTCAAACCAAAAGAAGCGCTTCAAGAGCTTGTAAACAAACATCTTTAA

Upstream 100 bases:

>100_bases
GCTGTGATCAGGAAAAAATAATTTGTAAGCATTAAAATAGCGTGAACGAATGGGAGATGCTATACTAAAAATCATCATTT
CACATTGGAGGAATTCAATA

Downstream 100 bases:

>100_bases
TTTTCCGCTGCTTACATGCCAGAGCGATTCCGATTGAGGGATCGCTTTTTTTATTCGCCAATTGTGAACCATAGAGAAAA
ACAAACGTTCGTGTTAAACT

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 104; Mature: 103

Protein sequence:

>104_residues
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKD
GEVVETSVGFKPKEALQELVNKHL

Sequences:

>Translated_104_residues
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKD
GEVVETSVGFKPKEALQELVNKHL
>Mature_103_residues
AIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDG
EVVETSVGFKPKEALQELVNKHL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=88, Percent_Identity=38.6363636363636, Blast_Score=75, Evalue=9e-15,
Organism=Homo sapiens, GI42794771, Length=101, Percent_Identity=32.6732673267327, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI224493972, Length=101, Percent_Identity=32.6732673267327, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=36.9047619047619, Blast_Score=67, Evalue=2e-12,
Organism=Homo sapiens, GI38505222, Length=104, Percent_Identity=31.7307692307692, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=48.0769230769231, Blast_Score=108, Evalue=8e-26,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=40, Blast_Score=89, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71998175, Length=96, Percent_Identity=36.4583333333333, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17509965, Length=84, Percent_Identity=44.047619047619, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=36.9047619047619, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=84, Percent_Identity=36.9047619047619, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=85, Percent_Identity=43.5294117647059, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=35.8024691358025, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507705, Length=85, Percent_Identity=30.5882352941176, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144092, Length=97, Percent_Identity=34.020618556701, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=39.7727272727273, Blast_Score=71, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6323072, Length=81, Percent_Identity=43.2098765432099, Blast_Score=71, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=41.0958904109589, Blast_Score=64, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24639826, Length=87, Percent_Identity=43.6781609195402, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17648013, Length=91, Percent_Identity=39.5604395604396, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583090, Length=91, Percent_Identity=39.5604395604396, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573567, Length=88, Percent_Identity=38.6363636363636, Blast_Score=76, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=49.1803278688525, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_BACSU (P14949)

Other databases:

- EMBL:   J03294
- EMBL:   Z75208
- EMBL:   AL009126
- EMBL:   X79976
- EMBL:   X99275
- PIR:   B37192
- RefSeq:   NP_390728.1
- PDB:   2GZY
- PDB:   2GZZ
- PDB:   2IPA
- PDB:   2VOC
- PDBsum:   2GZY
- PDBsum:   2GZZ
- PDBsum:   2IPA
- PDBsum:   2VOC
- ProteinModelPortal:   P14949
- SMR:   P14949
- EnsemblBacteria:   EBBACT00000002625
- GeneID:   938187
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU28500
- NMPDR:   fig|224308.1.peg.2853
- GenoList:   BSU28500
- GeneTree:   EBGT00050000000762
- HOGENOM:   HBG493509
- OMA:   TLMLFKG
- PhylomeDB:   P14949
- ProtClustDB:   CLSK2460947
- BioCyc:   BSUB:BSU28500-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11393; Mature: 11262

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDEN
CCEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNKHL
CCCCCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQEMGDKLKIVKIDVDEN
CEEECCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCC
QETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNKHL
CCCCCCCCCCCCCEEEEEECCCEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892