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The map label for this gene is uvrC

Identifier: 255767657

GI number: 255767657

Start: 2911116

End: 2912888

Strand: Reverse

Name: uvrC

Synonym: BSU28490

Alternate gene names: 255767657

Gene position: 2912888-2911116 (Counterclockwise)

Preceding gene: 16079902

Following gene: 16079899

Centisome position: 69.1

GC content: 45.35

Gene sequence:

>1773_bases
ATGAACAAACAACTGAAAGAAAAACTCGCCCTCCTTCCTGATCAACCGGGTTGTTATCTCATGAAGGACCGGCAGCAGAC
TGTGATCTACGTAGGGAAAGCAAAAGTGCTGAAAAACAGAGTGCGCTCCTACTTCACCGGTTCTCACGACGCGAAAACCC
AAAGGCTTGTGACGGAAATCGAGGATTTTGAATATATTGTGACGTCCTCCAATCTTGAAGCGCTTATTTTAGAAATGAAT
CTGATCAAAAAGCATGATCCGAAATACAACGTCATGCTCAAAGACGACAAAACCTATCCTTTCATAAAACTCACCCATGA
ACGCCACCCAAGGCTGATTGTCACCCGCAATGTCAAAAAAGACAAAGGGCGCTATTTCGGGCCGTATCCGAATGTACAGG
CAGCAAGGGAAACAAAAAAACTGCTCGACCGTCTGTATCCTCTCAGAAAATGCTCCAAGCTCCCGGACAGAGTGTGCCTT
TACTATCATCTGGGCCAATGCCTTGCTCCGTGTGTAAAGGATATTTCCGAAGAGACGAACAGAGAGCTGGTTGAAAGCAT
TACACGTTTCTTAAGGGGCGGCTATAATGAGGTCAAAAAAGAGCTTGAAGAGAAAATGCATGAAGCTGCTGAGAATCTTG
AGTTTGAACGAGCAAAAGAGCTTCGTGACCAAATTGCCCATATTGAATCAACGATGGAAAAACAAAAAATGACGATGAAC
GATCTAGTCGACCGTGATGTGTTCGCGTACGCGTACGATAAGGGCTGGATGTGCGTGCAGGTCTTTTTCATCCGCCAAGG
AAAGCTCATTGAACGCGATGTCAGCATGTTCCCGCTTTATCAGGAAGCAGATGAAGAGTTCCTCACGTTCATCGGGCAGT
TCTATTCAAAAAACAACCACTTCCTTCCGAAGGAGATTTTAGTTCCGGACAGCATAGATCAATCTATGATCGAGCAGCTA
CTGGAAACAAACGTTCACCAGCCGAAAAAAGGCCCGAAAAAAGAACTGCTCATGCTTGCCCATAAAAATGCGAAAATCGC
ATTGAAAGAAAAATTCTCTTTAATCGAACGGGACGAGGAGCGTTCAATCGGGGCAGTGCAGAAACTAGGTGAGGCATTAA
ATATTTATACGCCGCACAGAATTGAAGCGTTTGATAACTCAAATATACAGGGGACAAACCCGGTTTCCGCGATGATTGTG
TTTATCGATGGCAAACCATACAAAAAGGAATACCGCAAATATAAAATCAAAACTGTTACAGGGCCGGATGATTACGGTTC
TATGAGAGAGGTTGTCAGAAGACGCTATACGAGAGTGCTTCGTGAGAATCTGCCGCTGCCCGATCTGATTATCATTGACG
GAGGAAAAGGGCAGATCAACGCAGCAAGGGATGTCATTGAAAATGAACTCGGCTTGGATATCCCGATCGCCGGTTTAGCG
AAAGATGAAAAACACAGAACCTCAAATTTACTGATCGGTGATCCGCTGGAGGTGGCGTATCTGGAACGAAACAGCCAGGA
ATTTTACCTCCTGCAGCGCATTCAGGACGAGGTGCACCGTTTTGCAATCAGTTTTCACAGGCAAATCCGGGGAAAAAGCG
CGTTTCAATCCGTTTTGGACGACATCCCGGGTATCGGAGAGAAAAGAAAGAAAATGCTGTTAAAGCATTTCGGTTCCGTT
AAAAAAATGAAGGAAGCAAGCCTTGAGGACATCAAAAAAGCCGGTGTTCCCGCAGCGGCGGCTCAGCTCCTTTACGACAA
ATTGCAAAAATAA

Upstream 100 bases:

>100_bases
GAGGGATCGCTTTTTTTATTCGCCAATTGTGAACCATAGAGAAAAACAAACGTTCGTGTTAAACTGGAAATAAAGGATTA
AACATAAGGAAGGGTAACAT

Downstream 100 bases:

>100_bases
TGTTGTCCTTTTAAATAAGATCTGATAAAATGTGAACTAATTTCATAGTTAGATCGTGTTATATGGTGAAGATAGAGGTG
CGAACTTCAAGAGTATGCCT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYFTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMN
LIKKHDPKYNVMLKDDKTYPFIKLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL
YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELRDQIAHIESTMEKQKMTMN
DLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQL
LETNVHQPKKGPKKELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMIV
FIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQINAARDVIENELGLDIPIAGLA
KDEKHRTSNLLIGDPLEVAYLERNSQEFYLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSV
KKMKEASLEDIKKAGVPAAAAQLLYDKLQK

Sequences:

>Translated_590_residues
MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYFTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMN
LIKKHDPKYNVMLKDDKTYPFIKLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL
YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELRDQIAHIESTMEKQKMTMN
DLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQL
LETNVHQPKKGPKKELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMIV
FIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQINAARDVIENELGLDIPIAGLA
KDEKHRTSNLLIGDPLEVAYLERNSQEFYLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSV
KKMKEASLEDIKKAGVPAAAAQLLYDKLQK
>Mature_590_residues
MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYFTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMN
LIKKHDPKYNVMLKDDKTYPFIKLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL
YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELRDQIAHIESTMEKQKMTMN
DLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQL
LETNVHQPKKGPKKELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMIV
FIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQINAARDVIENELGLDIPIAGLA
KDEKHRTSNLLIGDPLEVAYLERNSQEFYLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSV
KKMKEASLEDIKKAGVPAAAAQLLYDKLQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=619, Percent_Identity=38.610662358643, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 68473; Mature: 68473

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYFTGSHDAKTQRLVTEI
CCHHHHHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFIKLTHERHPRLIVTRNVKK
HHCEEEEECCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEEEECCCC
DKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCLYYHLGQCLAPCVKDISEETN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELRDQIAHIESTMEKQKMTMN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQEADEEFLTFIGQFYSKNNH
HHHHHHHHEEEECCCCEEEEEEHHHCCCHHHHCHHHCCCHHHHHHHHHHHHHHHHCCCCC
FLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKKELLMLAHKNAKIALKEKFSLIERDEE
CCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHCCHH
RSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMIVFIDGKPYKKEYRKYKIKTVT
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHEEEEEEEC
GPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQINAARDVIENELGLDIPIAGLA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
KDEKHRTSNLLIGDPLEVAYLERNSQEFYLLQRIQDEVHRFAISFHRQIRGKSAFQSVLD
CCHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DIPGIGEKRKKMLLKHFGSVKKMKEASLEDIKKAGVPAAAAQLLYDKLQK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSYFTGSHDAKTQRLVTEI
CCHHHHHHHHCCCCCCCEEEEECCCCEEEEECHHHHHHHHHHHHHCCCCCHHHHHHHHHH
EDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFIKLTHERHPRLIVTRNVKK
HHCEEEEECCCCCEEHHHHHHHHCCCCCEEEEEECCCCCCEEEEECCCCCEEEEEECCCC
DKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCLYYHLGQCLAPCVKDISEETN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERAKELRDQIAHIESTMEKQKMTMN
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSMFPLYQEADEEFLTFIGQFYSKNNH
HHHHHHHHEEEECCCCEEEEEEHHHCCCHHHHCHHHCCCHHHHHHHHHHHHHHHHCCCCC
FLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKKELLMLAHKNAKIALKEKFSLIERDEE
CCCHHCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEHHHHHHHHHCCHH
RSIGAVQKLGEALNIYTPHRIEAFDNSNIQGTNPVSAMIVFIDGKPYKKEYRKYKIKTVT
HHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHEEEEEEEC
GPDDYGSMREVVRRRYTRVLRENLPLPDLIIIDGGKGQINAARDVIENELGLDIPIAGLA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
KDEKHRTSNLLIGDPLEVAYLERNSQEFYLLQRIQDEVHRFAISFHRQIRGKSAFQSVLD
CCHHHCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
DIPGIGEKRKKMLLKHFGSVKKMKEASLEDIKKAGVPAAAAQLLYDKLQK
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA