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The map label for this gene is nadC

Identifier: 16079838

GI number: 16079838

Start: 2847048

End: 2847917

Strand: Reverse

Name: nadC

Synonym: BSU27860

Alternate gene names: 16079838

Gene position: 2847917-2847048 (Counterclockwise)

Preceding gene: 16079839

Following gene: 16079837

Centisome position: 67.56

GC content: 43.45

Gene sequence:

>870_bases
ATGAATCATTTACAGCTGAAAAAATTACTGAATCACTTTTTTCTTGAGGATATTGGGACAGGGGATCTTACATCGCAGTC
TATTTTTGGAGAACAGAGCTGTGAAGCGGAGATTGTTGCAAAGTCAGAGGGTATTTTTGCAGGAGCAGCGATCATAAAAG
AAGGCTTTTCGTTATTGGACGAAAATGTTCAAAGCATTTTACACAAAAAAGATGGGGACATGTTGCATAAAGGTGAAGTG
ATTGCCGAGTTACACGGTCCCGCAGCTGCGCTCCTTTCAGGAGAGCGGGTCGTATTAAATCTTATTCAGAGGCTGTCAGG
AATTGCGACAATGACAAGAGAGGCTGTTCGGTGTCTGGATGATGAACAGATTAAAATTTGTGACACGAGAAAAACAACAC
CGGGGCTCAGAATGCTGGAGAAATATGCTGTCAGAGCCGGCGGCGGGTATAATCATCGATTCGGTTTGTATGACGGCATC
ATGATTAAAGATAATCATATCGCAGCATGCGGCTCTATTTTAGAGGCGTGCAAAAAAGCCCGTCAGGCCGCAGGGCACAT
GGTAAATATCGAGGTGGAAATTGAAACGGAGGAACAGCTGCGGGAAGCAATTGCAGCTGGAGCGGATGTTATTATGTTTG
ACAACTGTCCGCCTGATACGGTCCGTCATTTTGCAAAGCTCACACCGGCTAATATAAAAACTGAAGCCTCTGGCGGGATT
ACGTTAGAATCTTTGCCTGCTTTTAAAGGGACGGGTGTGAATTATATTTCATTAGGATTTCTGACTCATTCCGTCAAAAG
TTTAGATATCAGCATGGATGTTACGTTATCAAATGAATCTGTGGAGGAATGCTGTTATGTCAATTCTTGA

Upstream 100 bases:

>100_bases
CGCACCGATTTTCCTCATGCTGAGGTGAGCTGGCAAGGAAGACAAATTGTCCATACAAAAAAAGGAACGAAGATCAGAAA
AAACGAGGGGATTTGGAACA

Downstream 100 bases:

>100_bases
TGTGATCAAACAATCGAATGATATGATGCCCGAAAGTTATAAAGAACTATCGAGAAAGGATATGGAAACGCGCGTTGCCG
CCATTAAGAAAAAGTTCGGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEV
IAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI
MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGI
TLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS

Sequences:

>Translated_289_residues
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEV
IAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI
MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGI
TLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS
>Mature_289_residues
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEV
IAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI
MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGI
TLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS

Specific function: Involved in the catabolism of quinolinic acid (QA)

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family

Homologues:

Organism=Homo sapiens, GI45269149, Length=279, Percent_Identity=36.2007168458781, Blast_Score=161, Evalue=6e-40,
Organism=Escherichia coli, GI1786299, Length=263, Percent_Identity=41.06463878327, Blast_Score=179, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=33.8078291814947, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADC_BACSU (P39666)

Other databases:

- EMBL:   AL009126
- EMBL:   M98822
- PIR:   G69663
- RefSeq:   NP_390664.1
- ProteinModelPortal:   P39666
- SMR:   P39666
- EnsemblBacteria:   EBBACT00000000487
- GeneID:   936245
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU27860
- NMPDR:   fig|224308.1.peg.2789
- GenoList:   BSU27860
- GeneTree:   EBGT00050000000838
- HOGENOM:   HBG751540
- OMA:   IATIEGP
- PhylomeDB:   P39666
- ProtClustDB:   PRK08072
- BioCyc:   BSUB:BSU27860-MONOMER
- BRENDA:   2.4.2.19
- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00078

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N; SSF51690 Q_phspho_trans

EC number: =2.4.2.19

Molecular weight: Translated: 31393; Mature: 31393

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: BINDING 96-96 BINDING 153-153 BINDING 163-163 BINDING 193-193 BINDING 214-214

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLD
CCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLD
HHHHHHHHCCCCCCEECCCCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKA
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
RQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGI
HHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCEECCCCCE
TLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS
EEECCCCCCCCCCCEEEHHHHHHHHHHEEEEEEEEECCCCHHHHHCCCC
>Mature Secondary Structure
MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEGIFAGAAIIKEGFSLLD
CCHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHH
ENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLIQRLSGIATMTREAVRCLD
HHHHHHHHCCCCCCEECCCCCEECCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCC
DEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGIMIKDNHIAACGSILEACKKA
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHH
RQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPPDTVRHFAKLTPANIKTEASGGI
HHHCCCEEEEEEEECCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCCCEECCCCCE
TLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTLSNESVEECCYVNS
EEECCCCCCCCCCCEEEHHHHHHHHHHEEEEEEEEECCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659