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The map label for this gene is dxs

Identifier: 16079483

GI number: 16079483

Start: 2523713

End: 2525614

Strand: Reverse

Name: dxs

Synonym: BSU24270

Alternate gene names: 16079483

Gene position: 2525614-2523713 (Counterclockwise)

Preceding gene: 255767538

Following gene: 255767537

Centisome position: 59.91

GC content: 47.74

Gene sequence:

>1902_bases
TTGGATCTTTTATCAATACAGGACCCGTCGTTTTTAAAAAACATGTCCATTGATGAATTAGAGAAATTAAGTGATGAAAT
CCGTCAGTTTTTAATTACAAGTTTATCCGCTTCCGGCGGCCACATCGGCCCAAACTTAGGTGTCGTAGAGCTTACTGTTG
CCCTGCATAAGGAATTTAACAGCCCGAAAGACAAATTTTTATGGGATGTAGGCCATCAGTCGTATGTCCATAAGCTGCTG
ACAGGACGCGGAAAAGAATTTGCGACGCTTCGCCAGTACAAAGGGCTTTGCGGATTTCCAAAGCGGAGTGAAAGCGAGCA
CGATGTTTGGGAAACCGGGCACAGCTCGACTTCTCTGTCAGGCGCGATGGGAATGGCAGCTGCCCGTGATATTAAAGGAA
CGGATGAATATATTATTCCGATCATTGGTGACGGCGCGCTGACCGGCGGTATGGCGCTCGAAGCCCTTAACCACATCGGC
GACGAGAAAAAAGACATGATTGTCATCCTTAATGATAATGAAATGAGTATTGCGCCAAACGTCGGTGCCATTCACTCTAT
GCTCGGACGGCTCCGCACTGCGGGGAAATACCAGTGGGTCAAAGATGAGCTTGAATACTTATTTAAAAAGATTCCGGCAG
TTGGGGGCAAGCTTGCCGCCACGGCGGAACGGGTCAAAGACAGCCTGAAATACATGCTCGTCTCCGGAATGTTTTTCGAG
GAGCTCGGTTTTACGTATTTGGGCCCAGTGGACGGACATTCTTATCATGAGCTGATTGAGAATCTTCAATACGCCAAAAA
AACGAAAGGCCCTGTTCTTCTGCACGTCATTACGAAAAAAGGGAAGGGGTACAAACCGGCTGAGACCGATACGATTGGGA
CATGGCATGGTACCGGACCATATAAAATTAATACCGGTGACTTTGTAAAGCCGAAAGCCGCAGCTCCTTCGTGGAGCGGT
CTTGTCAGCGGAACTGTGCAGCGAATGGCGCGCGAGGACGGACGCATTGTAGCCATTACGCCGGCTATGCCTGTCGGTTC
AAAGCTTGAAGGCTTCGCAAAGGAATTCCCTGACCGGATGTTCGACGTAGGAATCGCAGAACAGCATGCCGCAACAATGG
CTGCAGCTATGGCAATGCAGGGTATGAAGCCGTTTTTGGCGATTTACTCAACCTTCCTGCAAAGGGCATATGACCAAGTT
GTTCATGACATCTGCCGCCAAAACGCTAATGTGTTTATTGGAATTGACCGTGCTGGACTCGTTGGCGCTGATGGAGAGAC
ACATCAAGGCGTGTTTGATATTGCGTTTATGCGCCACATTCCAAACATGGTCTTAATGATGCCGAAAGACGAAAATGAAG
GCCAGCACATGGTTCATACAGCACTTAGCTATGACGAAGGCCCGATAGCAATGCGTTTTCCGCGCGGAAACGGACTCGGC
GTAAAAATGGATGAACAGTTGAAAACGATTCCGATCGGTACGTGGGAGGTGCTGCGTCCAGGGAACGATGCTGTCATCTT
AACATTCGGCACAACAATCGAAATGGCGATTGAAGCAGCCGAAGAGCTGCAGAAAGAAGGCCTTTCCGTGCGCGTTGTGA
ATGCGCGTTTTATTAAGCCGATTGATGAAAAGATGATGAAGAGTATCCTAAAAGAAGGCTTGCCAATTTTAACAATTGAA
GAAGCGGTCTTAGAAGGCGGTTTCGGAAGCTCGATTTTAGAATTCGCTCATGATCAAGGTGAATATCATACTCCGATTGA
CAGAATGGGTATACCTGATCGGTTTATTGAACACGGAAGTGTAACAGCGCTTCTTGAGGAAATTGGACTGACAAAACAGC
AGGTGGCAAATCGTATTAGATTACTGATGCCACCAAAGACACACAAAGGAATTGGATCATGA

Upstream 100 bases:

>100_bases
AGCGCGTTTGTCTTTTTTTATGTCTGAGATTATTGTCAGCTCGGCATGCAAAAGACATGTATCATTGCAGAAATTCATGC
TGAAAGTGAGTTGATCCGCT

Downstream 100 bases:

>100_bases
CGTCAAAGAAAGAACGATTAGATGTATTATTAGTGGAAAGAGGGCTGGCGGAAACGCGTGAAAAAGCCAAAAGAGCCATT
ATGGCGGGGATCGTCTATTC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 633; Mature: 633

Protein sequence:

>633_residues
MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLL
TGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLG
VKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIE
EAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS

Sequences:

>Translated_633_residues
MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLL
TGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLG
VKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIE
EAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS
>Mature_633_residues
MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLL
TGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG
DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFE
ELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSG
LVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQV
VHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLG
VKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIE
EAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=670, Percent_Identity=23.2835820895522, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI4507521, Length=670, Percent_Identity=23.2835820895522, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI225637463, Length=282, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637459, Length=282, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI225637461, Length=282, Percent_Identity=27.6595744680851, Blast_Score=93, Evalue=9e-19,
Organism=Homo sapiens, GI133778974, Length=439, Percent_Identity=26.4236902050114, Blast_Score=89, Evalue=2e-17,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=45.4991816693944, Blast_Score=535, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI17539652, Length=418, Percent_Identity=24.8803827751196, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666278, Length=628, Percent_Identity=23.2484076433121, Blast_Score=106, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24645119, Length=533, Percent_Identity=24.015009380863, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45551847, Length=533, Percent_Identity=24.015009380863, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550715, Length=533, Percent_Identity=24.015009380863, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21358145, Length=262, Percent_Identity=24.8091603053435, Blast_Score=74, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650940, Length=262, Percent_Identity=24.8091603053435, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 69560; Mature: 69560

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFN
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHCC
SPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPN
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGP
HCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRM
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHH
FDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
VGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCC
VKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKP
CEECCCCCEECCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCH
IDEKMMKSILKEGLPILTIEEAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHCCH
VTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS
HHHHHHHHCCCHHHHHHHHEEEECCCCCCCCCC
>Mature Secondary Structure
MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGPNLGVVELTVALHKEFN
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHCC
SPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKRSESEHDVWETGHSSTSLS
CCHHHHEECCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHCCCCCCCCH
GAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIGDEKKDMIVILNDNEMSIAPN
HHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCC
VGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKLAATAERVKDSLKYMLVSGMFFE
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHVITKKGKGYKPAETDTIGTWHGTGP
HCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCC
YKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDGRIVAITPAMPVGSKLEGFAKEFPDRM
EEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHH
FDVGIAEQHAATMAAAMAMQGMKPFLAIYSTFLQRAYDQVVHDICRQNANVFIGIDRAGL
HHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCE
VGADGETHQGVFDIAFMRHIPNMVLMMPKDENEGQHMVHTALSYDEGPIAMRFPRGNGLG
ECCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCC
VKMDEQLKTIPIGTWEVLRPGNDAVILTFGTTIEMAIEAAEELQKEGLSVRVVNARFIKP
CEECCCCCEECCCCCEEECCCCCEEEEEECCHHHHHHHHHHHHHHCCCEEEEECHHHCCH
IDEKMMKSILKEGLPILTIEEAVLEGGFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGS
HHHHHHHHHHHCCCCEEEEHHHHHCCCCCHHHHHHHHCCCCCCCCHHHCCCCHHHHHCCH
VTALLEEIGLTKQQVANRIRLLMPPKTHKGIGS
HHHHHHHHCCCHHHHHHHHEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA