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The map label for this gene is mmgA

Identifier: 16079473

GI number: 16079473

Start: 2512861

End: 2514042

Strand: Reverse

Name: mmgA

Synonym: BSU24170

Alternate gene names: 16079473

Gene position: 2514042-2512861 (Counterclockwise)

Preceding gene: 255767532

Following gene: 255767531

Centisome position: 59.64

GC content: 51.78

Gene sequence:

>1182_bases
ATGAGGAAAACAGTCATTGTAAGTGCTGCAAGAACTCCATTTGGCAAATTCGGCGGAGTTTTGAAAGAGGTGAAAGCTGC
TGAGCTTGGGGGCATTGTGATGAAGGAGGCGCTGCAACAGGCTGGAGTCTCTGGAGATGATGTAGAAGGAAACGTCATGG
GCATGGTTGTCCAGGCCGGCTCAGGGCAGATACCTTCCCGTCAAGCTGCCCGTCTGGCGGGAATGCCTTGGAGTGTGCCG
TCAGAAACACTGAATAAAGTCTGTGCTTCCGGCCTTCGCGCTGTCACTTTATGTGATCAAATGATTCGGGCGCAGGATGC
GGACATACTTGTTGCGGGGGGGATGGAAAGCATGAGCAATATTCCGTATGCCGTTCCCGCCGGGCGCTGGGGAGCACGGA
TGGGGGACGGCGAGCTTAGGGACTTAATGGTGTATGACGGATTAACGTGCGCATTTGACGAGGTGCACATGGCTGTTCAC
GGAAATACAGCTGCCAAGGAATATGCAATCTCACGAAGAGAGCAGGACGAATGGGCGTTGAGAAGTCATGCAAGGGCAGC
TAAGGCCGCCGATGAAGGGAAGTTTCAGGATGAAATTGTTCCCGTCAACTGGATCGGTCGAAAAGGAAAACCAAACGTTG
TTGATAAAGATGAAGCGATTCGCCGTGACACAAGTCTGGATCAGCTCGCAAAACTTGCTCCGATTTATGCAAGTGACGGT
TCTATCACAGCCGGCAATGCTCCTGGAGTCAATGACGGAGCCGGCGCGTTCGTGCTGATGTCTGAGGAAAAAGCTGCTGA
GCTTGGCAAACGGCCTCTGGCTACAATTCTTGGTTTTTCAACTACGGGAATGCCAGCGCACGAGCTGGCGGCAGCGCCAG
GGTTTGCTATTAACAAGCTCCTGAAAAAGAATGGTTTAACTGTCCAAGATATTGACTTGTTTGAAGTAAATGAAGCTTTT
GCTTCAGTTGTTTTGACATGTGAAAAAATCGTAGGTTTCGATCTTGAAAAAGTAAATGTGAATGGCGGTGCGATCGCGCT
CGGCCACCCGATCGGCGCGAGCGGTGCGAGAATTCTCATGACGCTTGTTTATGAATTAAAGCGACGGGGAGGGGGTCTGG
GCGTTGCCGCTATTTGCAGCGGGGCAGCACAGGGAGACGCCGTCTTAGTGCAGGTTCATTAA

Upstream 100 bases:

>100_bases
GCCTTCTTTTTTCATTCATTCATGCCCGTTTCAAAGCATACATTCATAGAAGACAACTAGAAATTGTAAGCGCTGTCTAT
CTTCTGAATGAGGTGAAACC

Downstream 100 bases:

>100_bases
AACATGATGAAAAAGGGGATTTGAATGGAAATCAAACAAATCATGGTAGCTGGCGCAGGTCAGATGGGGAGCGGAATTGC
TCAAACAGCCGCCGACGCGG

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVP
SETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH
GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDG
SITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAF
ASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH

Sequences:

>Translated_393_residues
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVP
SETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH
GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDG
SITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAF
ASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH
>Mature_393_residues
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVP
SETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH
GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDG
SITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAF
ASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family

Homologues:

Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=42.3469387755102, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI148539872, Length=389, Percent_Identity=44.4730077120823, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=41.1616161616162, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI4501853, Length=393, Percent_Identity=38.4223918575064, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI4504327, Length=428, Percent_Identity=33.1775700934579, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI194353979, Length=390, Percent_Identity=29.7435897435897, Blast_Score=135, Evalue=6e-32,
Organism=Escherichia coli, GI87082165, Length=391, Percent_Identity=45.2685421994885, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1788554, Length=392, Percent_Identity=46.9387755102041, Blast_Score=321, Evalue=4e-89,
Organism=Escherichia coli, GI1787663, Length=399, Percent_Identity=38.3458646616541, Blast_Score=251, Evalue=4e-68,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=35.8208955223881, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1788683, Length=408, Percent_Identity=30.8823529411765, Blast_Score=174, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25147385, Length=390, Percent_Identity=41.2820512820513, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI133906874, Length=387, Percent_Identity=40.0516795865633, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=37.7215189873418, Blast_Score=240, Evalue=9e-64,
Organism=Caenorhabditis elegans, GI17551802, Length=428, Percent_Identity=32.0093457943925, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17535917, Length=402, Percent_Identity=32.5870646766169, Blast_Score=178, Evalue=4e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=395, Percent_Identity=41.2658227848101, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=35.7868020304569, Blast_Score=208, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24655093, Length=391, Percent_Identity=45.7800511508951, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24640423, Length=390, Percent_Identity=42.8205128205128, Blast_Score=298, Evalue=3e-81,
Organism=Drosophila melanogaster, GI17648125, Length=388, Percent_Identity=37.6288659793814, Blast_Score=238, Evalue=7e-63,
Organism=Drosophila melanogaster, GI17137578, Length=430, Percent_Identity=33.4883720930233, Blast_Score=195, Evalue=5e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): THL_BACSU (P45855)

Other databases:

- EMBL:   U29084
- EMBL:   D84432
- EMBL:   AL009126
- PIR:   B69658
- RefSeq:   NP_390297.1
- ProteinModelPortal:   P45855
- SMR:   P45855
- EnsemblBacteria:   EBBACT00000000262
- GeneID:   938662
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU24170
- NMPDR:   fig|224308.1.peg.2421
- GenoList:   BSU24170
- GeneTree:   EBGT00050000001410
- HOGENOM:   HBG370930
- OMA:   TINDGAC
- PhylomeDB:   P45855
- ProtClustDB:   PRK08235
- BioCyc:   BSUB:BSU24170-MONOMER
- BRENDA:   2.3.1.9
- GO:   GO:0005737
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616
- Gene3D:   G3DSA:3.40.47.10
- PANTHER:   PTHR18919
- PIRSF:   PIRSF000429
- TIGRFAMs:   TIGR01930

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N; SSF53901 Thiolase-like

EC number: =2.3.1.9

Molecular weight: Translated: 41180; Mature: 41180

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00098 THIOLASE_1; PS00737 THIOLASE_2; PS00099 THIOLASE_3

Important sites: ACT_SITE 88-88 ACT_SITE 349-349 ACT_SITE 379-379

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAG
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC
SGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
IPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVHGNTAAKEYAISRREQDEWAL
CCEECCCCCCCCCCCCCCHHEEHEECCCEEEHHHEEEEEECCCHHHHHHHHCCCCHHHHH
RSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHCCEEECCC
SITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKL
CEECCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHHCCCCCCCCHHHHHCCCCHHHHHH
LKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILM
HHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHH
TLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH
HHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure
MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVSGDDVEGNVMGMVVQAG
CCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC
SGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMIRAQDADILVAGGMESMSN
CCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHC
IPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVHGNTAAKEYAISRREQDEWAL
CCEECCCCCCCCCCCCCCHHEEHEECCCEEEHHHEEEEEECCCHHHHHHHHCCCCHHHHH
RSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDEAIRRDTSLDQLAKLAPIYASDG
HHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHHCCCHHHHHHHCCEEECCC
SITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATILGFSTTGMPAHELAAAPGFAINKL
CEECCCCCCCCCCCCEEEEECCHHHHHHCCCCHHHHHCCCCCCCCHHHHHCCCCHHHHHH
LKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFDLEKVNVNGGAIALGHPIGASGARILM
HHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCHHHHHH
TLVYELKRRGGGLGVAAICSGAAQGDAVLVQVH
HHHHHHHHCCCCCCHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377