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The map label for this gene is ribA

Identifier: 16079383

GI number: 16079383

Start: 2428389

End: 2429585

Strand: Reverse

Name: ribA

Synonym: BSU23260

Alternate gene names: 16079383

Gene position: 2429585-2428389 (Counterclockwise)

Preceding gene: 16079384

Following gene: 16079382

Centisome position: 57.63

GC content: 46.12

Gene sequence:

>1197_bases
ATGTTTCATCCGATAGAAGAAGCACTGGACGCTTTAAAAAAAGGCGAAGTCATCATCGTTGTAGATGATGAAGACAGAGA
AAATGAAGGAGACTTTGTGGCTCTTGCCGAGCATGCAACGCCGGAAGTCATTAACTTTATGGCGACACATGGGAGAGGAC
TGATCTGCACGCCGCTCAGTGAGGAAATCGCAGACAGGCTTGATCTTCACCCTATGGTTGAGCATAATACAGACTCTCAC
CACACTGCATTTACCGTAAGCATAGACCATCGTGAAACGAAGACAGGTATCAGCGCTCAAGAAAGATCTTTTACCGTTCA
AGCATTGCTGGACAGCAAATCCGTGCCATCTGATTTTCAGCGTCCGGGGCACATTTTTCCACTGATTGCGAAAAAAGGAG
GTGTCCTGAAAAGAGCGGGCCATACAGAAGCTGCTGTTGATCTTGCTGAAGCTTGCGGATCTCCAGGAGCCGGCGTCATT
TGTGAAATTATGAATGAAGACGGAACGATGGCGAGAGTGCCTGAGCTCATTGAAATTGCGAAAAAGCATCAATTAAAAAT
GATCACCATTAAGGATTTGATTCAATACCGTTACAATCTGACAACACTTGTCGAGCGTGAAGTTGACATTACGCTGCCTA
CTGATTTTGGGACATTTAAGGTTTATGGATACACAAATGAGGTAGATGGAAAAGAGCATGTCGCATTTGTGATGGGAGAT
GTGCCGTTCGGAGAAGAACCGGTATTGGTCCGGGTGCATTCAGAATGTCTCACAGGTGACGTGTTTGGCTCTCATCGCTG
TGATTGCGGACCGCAGCTGCACGCCGCGCTGAACCAAATTGCCGCAGAAGGCCGTGGAGTGCTCCTGTACTTGCGCCAAG
AAGGACGAGGCATCGGTTTAATCAATAAATTAAAAGCTTATAAGCTTCAGGAACAAGGCTATGACACCGTAGAAGCCAAT
GAGGCGCTTGGATTCTTGCCGGATCTTCGCAACTATGGCATCGGAGCACAAATTTTACGCGACCTCGGTGTCCGGAATAT
GAAGCTTTTGACGAATAATCCGCGAAAAATCGCAGGCCTTGAAGGCTACGGACTCAGTATTTCAGAAAGAGTGCCGCTTC
AAATGGAGGCGAAAGAACACAATAAAAAATATTTGCAAACCAAAATGAACAAGCTAGGTCATTTACTTCATTTCTAA

Upstream 100 bases:

>100_bases
ATATGTATCGATTTTTGCATAAAGCCAATGAAAATAAGACCCAACAAACCATTACAAAAGCCTTCTTAAGCGAAAACGGC
TTTTAGAGAGGAAGATTTGC

Downstream 100 bases:

>100_bases
TCACAAATATCACAAAAAAGGATGGGAATCATATGAATATCATACAAGGAAATTTAGTTGGTACAGGTCTTAAAATCGGA
ATCGTAGTAGGAAGATTTAA

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVINFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSH
HTAFTVSIDHRETKTGISAQERSFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI
CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGTFKVYGYTNEVDGKEHVAFVMGD
VPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEAN
EALGFLPDLRNYGIGAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKLGHLLHF

Sequences:

>Translated_398_residues
MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVINFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSH
HTAFTVSIDHRETKTGISAQERSFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI
CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGTFKVYGYTNEVDGKEHVAFVMGD
VPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEAN
EALGFLPDLRNYGIGAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKLGHLLHF
>Mature_398_residues
MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVINFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSH
HTAFTVSIDHRETKTGISAQERSFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI
CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGTFKVYGYTNEVDGKEHVAFVMGD
VPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEAN
EALGFLPDLRNYGIGAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKLGHLLHF

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=54.639175257732, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1789420, Length=197, Percent_Identity=49.746192893401, Blast_Score=199, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=44.1747572815534, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319438, Length=171, Percent_Identity=46.1988304093567, Blast_Score=130, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 44122; Mature: 44122

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVINFMATHGRGLICTPLS
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCH
EEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQERSFTVQALLDSKSVPSDFQ
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCEEEEEECCCCCCCHHHC
RPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVICEIMNEDGTMARVPELIEIA
CCCCEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
KKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGTFKVYGYTNEVDGKEHVAFVMGD
HHCCEEEEEHHHHHHHHHCHHEEEEEEEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEC
VPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALNQIAAEGRGVLLYLRQEGRGIGL
CCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
INKLKAYKLQEQGYDTVEANEALGFLPDLRNYGIGAQILRDLGVRNMKLLTNNPRKIAGL
HHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCEEECC
EGYGLSISERVPLQMEAKEHNKKYLQTKMNKLGHLLHF
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVINFMATHGRGLICTPLS
CCCCHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHCCCEEEECCCH
EEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQERSFTVQALLDSKSVPSDFQ
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHCEEEEEECCCCCCCHHHC
RPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVICEIMNEDGTMARVPELIEIA
CCCCEEEEEECCCCCEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHH
KKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGTFKVYGYTNEVDGKEHVAFVMGD
HHCCEEEEEHHHHHHHHHCHHEEEEEEEEEEECCCCCCEEEEEECCCCCCCCEEEEEEEC
VPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAALNQIAAEGRGVLLYLRQEGRGIGL
CCCCCCCEEEEEECHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCH
INKLKAYKLQEQGYDTVEANEALGFLPDLRNYGIGAQILRDLGVRNMKLLTNNPRKIAGL
HHHHHHHHHHHCCCCCCCCCCHHCCCCCHHHCCCHHHHHHHCCCCCEEEEECCCCEEECC
EGYGLSISERVPLQMEAKEHNKKYLQTKMNKLGHLLHF
CCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA