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The map label for this gene is desK

Identifier: 16078979

GI number: 16078979

Start: 2090574

End: 2091686

Strand: Direct

Name: desK

Synonym: BSU19190

Alternate gene names: 16078979

Gene position: 2090574-2091686 (Clockwise)

Preceding gene: 16078978

Following gene: 16078980

Centisome position: 49.59

GC content: 38.19

Gene sequence:

>1113_bases
ATGATTAAAAATCATTTTACATTTCAAAAACTAAACGGGATTACGCCCTATATATGGACGATATTTTTCATCCTCCCCTT
CTACTTTATATGGAAATCATCATCTACATTTGTTATTATTGTCGGCATCATTTTGACGCTTTTATTTTTTTCGGTATATC
GATTTGCTTTTGTCTCAAAAGGCTGGACCATTTATTTGTGGGGATTTTTATTAATTGGCATTTCAACCGCCTCCATTACT
CTGTTCAGTTATATTTATTTTGCTTTCTTTATTGCTTATTTTATTGGAAACATTAAGGAACGCGTCCCTTTTCATATTTT
ATATTATGTCCATTTAATAAGCGCGGCCGTCGCAGCCAATTTCAGTCTCGTATTAAAAAAGGAATTCTTTCTGACACAAA
TTCCTTTTGTCGTTATTACCCTCATCAGCGCAATTTTATTGCCCTTCAGTATAAAAAGCCGCAAGGAGCGCGAACGACTT
GAAGAAAAGCTCGAGGATGCAAATGAACGGATTGCAGAACTGGTAAAATTAGAAGAACGTCAGCGAATTGCCCGCGATCT
CCATGATACGCTTGGGCAAAAGCTTTCTCTTATTGGTTTAAAAAGCGACTTAGCAAGAAAATTGATATACAAAGATCCCG
AACAAGCAGCTCGTGAACTGAAAAGTGTTCAGCAAACAGCGCGAACTTCTTTAAATGAAGTAAGAAAAATCGTTTCCTCT
ATGAAGGGCATCCGGCTCAAGGATGAATTGATCAACATCAAACAAATTCTCGAAGCAGCTGACATTATGTTTATCTATGA
AGAAGAGAAATGGCCCGAGAATATCTCATTGCTGAATGAAAACATTTTGAGCATGTGCTTAAAGGAAGCTGTCACAAATG
TCGTCAAACACAGCCAGGCTAAAACTTGCCGAGTTGACATTCAGCAGCTCTGGAAGGAAGTTGTGATTACAGTGTCTGAC
GATGGAACATTCAAAGGAGAAGAAAATTCCTTTTCAAAAGGACATGGCTTACTCGGGATGAGAGAACGGCTTGAGTTTGC
AAACGGAAGCCTTCACATCGATACCGAAAACGGGACCAAGCTTACCATGGCAATTCCTAATAATTCAAAATAA

Upstream 100 bases:

>100_bases
ATATACTAGAAGGCTTCCTTTTTATTGTTGGAGGGTGCATTCTGGCTTTCACAATGATAAAGTTACAAGTAAGATGAAAA
GCTGAAAATGAGGTAAGATC

Downstream 100 bases:

>100_bases
ACATAAAGGATGGCTTATATGATTAGTATATTTATTGCAGAAGATCAGCAAATGCTGCTGGGCGCTTTAGGATCACTTCT
AAACCTCGAAGACGATATGG

Product: two-component sensor histidine kinase DesR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASIT
LFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL
EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSS
MKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSD
DGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK

Sequences:

>Translated_370_residues
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASIT
LFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL
EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSS
MKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSD
DGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK
>Mature_370_residues
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASIT
LFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL
EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSS
MKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSD
DGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK

Specific function: Member of the two-component regulatory system desR/desK, responsible for cold induction of the des gene coding for the Delta5 acyl-lipid desaturase. Acts as a sensor of the membrane fluidity. Probably activates desR by phosphorylation

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI87082311, Length=236, Percent_Identity=25.8474576271186, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DESK_BACSU (O34757)

Other databases:

- EMBL:   AF027868
- EMBL:   AL009126
- PIR:   C69901
- RefSeq:   NP_389800.1
- PDB:   3EHF
- PDB:   3EHG
- PDB:   3EHH
- PDB:   3EHJ
- PDB:   3GIE
- PDB:   3GIF
- PDB:   3GIG
- PDBsum:   3EHF
- PDBsum:   3EHG
- PDBsum:   3EHH
- PDBsum:   3EHJ
- PDBsum:   3GIE
- PDBsum:   3GIF
- PDBsum:   3GIG
- ProteinModelPortal:   O34757
- SMR:   O34757
- DIP:   DIP-48966N
- EnsemblBacteria:   EBBACT00000002836
- GeneID:   939678
- GenomeReviews:   AL009126_GR
- KEGG:   bsu:BSU19190
- NMPDR:   fig|224308.1.peg.1923
- GenoList:   BSU19190
- GeneTree:   EBGT00070000031823
- HOGENOM:   HBG700937
- OMA:   WTIFFIL
- ProtClustDB:   CLSK887413
- BioCyc:   BSUB:BSU19190-MONOMER
- InterPro:   IPR003594
- InterPro:   IPR011712
- Gene3D:   G3DSA:3.30.565.10
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF07730 HisKA_3; SSF55874 ATP_bd_ATPase

EC number: =2.7.13.3

Molecular weight: Translated: 42674; Mature: 42674

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb5c2274)-; HASH(0xee213bc)-; HASH(0xf37d64c)-; HASH(0xf46b500)-; HASH(0xd09d330)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSK
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCC
GWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERLEEKLEDANERIAELVKLEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQA
HCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTK
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCE
LTMAIPNNSK
EEEECCCCCH
>Mature Secondary Structure
MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGIILTLLFFSVYRFAFVSK
CCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHCC
GWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERVPFHILYYVHLISAAVAAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
FSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERLEEKLEDANERIAELVKLEER
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAARELKSVQQTARTSLNEVRKIVSS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGIRLKDELINIKQILEAADIMFIYEEEKWPENISLLNENILSMCLKEAVTNVVKHSQA
HCCCCHHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
KTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKGHGLLGMRERLEFANGSLHIDTENGTK
HHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCE
LTMAIPNNSK
EEEECCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377